1932

Abstract

Interindividual variability in the efficacy and toxicity of drug therapy is associated with polymorphisms in genes encoding drug-metabolizing enzymes, transporters, or drug targets. Pharmacogenetics aims to identify individuals predisposed to high risk of toxicity from conventional doses of cancer chemotherapeutic agents. We review the role of genetic polymorphisms in and , as well as mutations in , in influencing drug disposition and toxicity. Recent studies show that pharmacogenetic determinants may also influence treatment outcomes. We discuss the clinical significance of polymorphisms in , , and , as well as the polymorphic DNA repair genes and , in influencing reponse to chemotherapy and survival outcomes. Finally, the potential implications of transporter pharmacogenetics in influencing drug bioavailability are addressed.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.med.54.101601.152352
2003-02-01
2024-04-17
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.med.54.101601.152352
Loading
/content/journals/10.1146/annurev.med.54.101601.152352
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error