1932

Abstract

Abstract

The abilities to sense environmental and internal temperatures are required for survival, both for maintenance of homeostasis and for avoidance of tissue-damaging noxious temperatures. Vertebrates can sense external physical stimuli via specialized classes of neurons in the peripheral nervous system that project to the skin. Temperature-sensitive neurons can be divided into two classes: innocuous thermosensors (warm or cool) and noxious thermonociceptors (hot or cold). ThermoTRPs, a subset of the transient receptor potential family of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct thermal thresholds. In this review, we examine the extent to which thermoTRPs are responsible for providing a molecular basis for thermal sensation.

Keyword(s): chemesthesisDRGpainskinTRPA1TRPV
Loading

Article metrics loading...

/content/journals/10.1146/annurev.neuro.29.051605.112958
2006-07-21
2024-06-14
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.neuro.29.051605.112958
Loading
/content/journals/10.1146/annurev.neuro.29.051605.112958
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error