1932

Abstract

Melanoma is the deadliest form of skin cancer without an effective treatment. An understanding of the genetic basis of melanoma has recently shed light on some of the mechanisms of melanomagenesis. This review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on , , , and MAPK pathway targets (e.g., and ), apoptosis regulators (e.g., , , and -), and the tumor-suppressor genes and . New directions for therapeutics based on our current knowledge of the genes implicated in melanoma are also discussed.

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/content/journals/10.1146/annurev.pathol.3.121806.151541
2009-02-28
2024-06-15
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  • Article Type: Review Article
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