Cl transport in the loop of Henle is responsible for reclamation of 25–40% of the filtered NaCl load and for the formation of dilute urine. Our understanding of the physiologic and molecular mechanisms responsible for Cl reabsorption in both the thin ascending limb and thick ascending limb of Henle's loop has increased greatly over the last decade. Plasma membrane Cl channels are known to play an integral role in transcellular Cl transport in both the thin and thick ascending limbs. This review focuses on the functional characteristics and molecular identities of these Cl channels, as well as the role of these channels in the pathophysiology of disease.


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  • Article Type: Review Article
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