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Annual Review of Biophysics

Volume 50, 2021

Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder–Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid–Liquid Phase Transitions

Abstract

This review deals with two important concepts—protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder–based biological liquid–liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.

Keyword(s): intrinsically disordered protein, intrinsically disordered protein region, liquid–liquid phase separation, liquid–liquid phase transition, proteinaceous membrane-less organelle
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/content/journals/10.1146/annurev-biophys-062920-063704
2021-05-06
2024-04-20
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/content/journals/10.1146/annurev-biophys-062920-063704
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Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder–Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid–Liquid Phase Transitions
Annual Review of Biophysics 50, 135 (2021); https://doi.org/10.1146/annurev-biophys-062920-063704
/content/journals/10.1146/annurev-biophys-062920-063704
/content/journals/10.1146/annurev-biophys-062920-063704
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