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Annual Review of Cell and Developmental Biology

Volume 36, 2020

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

Abstract

The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.

Keyword(s): adult hematopoiesis, differentiation kinetics, hematopoietic stem cells, immune cell development, lineage commitment, lineage tracing
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/content/journals/10.1146/annurev-cellbio-020520-114601
2020-10-06
2024-04-20
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/content/journals/10.1146/annurev-cellbio-020520-114601
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The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Annual Review of Cell and Developmental Biology 36, 529 (2020); https://doi.org/10.1146/annurev-cellbio-020520-114601
/content/journals/10.1146/annurev-cellbio-020520-114601
/content/journals/10.1146/annurev-cellbio-020520-114601
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  • Article Type: Review Article

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