Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System

Literature Cited

1. Ackermann JA, Hofheinz K, Zaiss MM, Krönke G 2017. The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim. Biophys. Acta 1862:371–81
   [Google Scholar]
2. Adams GR, Zaldivar FP, Nance DM, Kodesh E, Radom-Aizik S, Cooper DM 2011. Exercise and leukocyte interchange among central circulation, lung, spleen, and muscle. Brain Behav. Immun. 25:658–66
   [Google Scholar]
3. Ahmed M, Henson DA, Sanderson MC, Nieman DC, Gillitt ND, Lila MA 2014. The protective effects of a polyphenol-enriched protein powder on exercise-induced susceptibility to virus infection. Phytother. Res. 28:1829–36
   [Google Scholar]
4. Akerstrom TC, Fischer CP, Plomgaard P, Thomsen C, van Hall G, Pedersen BK 2009. Glucose ingestion during endurance training does not alter adaptation. J. Appl. Physiol. 106:1771–79
   [Google Scholar]
5. Amin HP, Czank C, Raheem S, Zhang Q, Botting NP et al. 2015. Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Mol. Nutr. Food Res. 59:1095–106
   [Google Scholar]
6. Baker LB, Jeukendrup AE 2014. Optimal composition of fluid replacement beverages. Compr. Physiol. 4:575–620
   [Google Scholar]
7. Balentine DA, Dwyer JT, Erdman JW, Ferruzzi MG, Gaine PC et al. 2015. Recommendations on reporting requirements for flavonoids in research. Am. J. Clin. Nutr. 101:1113–25
   [Google Scholar]
8. Balfoussia E, Skenderi K, Tsironi M, Anagnostopoulos AK, Parthimos N et al. 2014. A proteomic study of plasma protein changes under extreme physical stress. J. Proteom. 98:1–14
   [Google Scholar]
9. Bartlett JD, Hawley JA, Morton JP 2015. Carbohydrate availability and exercise training adaptation: too much of a good thing. Eur. J. Sport Sci. 15:3–12
   [Google Scholar]
10. Bermon S, Castell LM, Calder PC, Bishop NC, Blomstrand E et al. 2017. Consensus statement: immunutrition and exercise. Exerc. Immunol. Rev. 23:8–50
    [Google Scholar]
11. Bhagwat S, Haytowitz DB, Holden JM 2014. USDA database for the flavonoid content of selected foods, release 3.1 Beltsville, MD: Nutr. Data Lab http://www.ars.usda.gov/nutrientdata/flav
    [Google Scholar]
12. Bigley AB, Rezvani K, Chew C, Sekine T, Pistillo M et al. 2014. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav. Immun. 39:160–71
    [Google Scholar]
13. Blackstock WP, Weir MP 1999. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol 17:121–27
    [Google Scholar]
14. Boushel R, Langberg H, Gemmer C, Olesen J, Crameri R et al. 2002. Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise. J. Physiol. 543:Pt. 2691–98
    [Google Scholar]
15. Calder PC 2017. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem. Soc. Trans. 45:1105–15
    [Google Scholar]
16. Caligiuri SPB, Parikh M, Stamenkovic A, Pierce GN, Aukema HM 2017. Dietary modulation of oxylipins in cardiovascular disease and aging. Am. J. Physiol. Heart Circ. Physiol. 313:H903–18
    [Google Scholar]
17. Cassidy A, Minihane AM 2017. The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. Am. J. Clin. Nutr. 105:10–22
    [Google Scholar]
18. Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF 2015. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Am. J. Clin. Nutr. 102:172–81
    [Google Scholar]
19. Cermak NM, van Loon LJ 2013. The use of carbohydrates during exercise as an ergogenic aid. Sports Med 43:1139–55
    [Google Scholar]
20. Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW et al. 2013. Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab. Investig. 93:690–700
    [Google Scholar]
21. Chorell E, Moritz T, Branth S, Antti H, Svensson MB 2009. Predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise. J. Proteome Res. 8:2966–77
    [Google Scholar]
22. Chow O, Barbul A 2014. Immunonutrition: role in wound healing and tissue regeneration. Adv. Wound Care 3:46–53
    [Google Scholar]
23. Cialdella-Kam L, Ghosh S, Meaney MP, Knab AM, Shanely RA, Nieman DC 2017. Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses to a 12-week high fat-diet in mice. Nutrients 9:7e773
    [Google Scholar]
24. Cialdella-Kam L, Nieman DC, Knab AM, Shanely RA, Meaney MP et al. 2016. A mixed flavonoid-fish oil supplement induces immune-enhancing and anti-inflammatory transcriptomic changes in adult obese and overweight women: a randomized controlled trial. Nutrients 8:5e277
    [Google Scholar]
25. Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T et al. 2013. Human metabolism and elimination of the anthocyanin, cyaniding-3-glucoside: a 13C-tracer study. Am. J. Clin. Nutr. 97:995–1003
    [Google Scholar]
26. Davison G, Kehaya C, Diment BC, Walsh NP 2016. Carbohydrate supplementation does not blunt the prolonged exercise-induced reduction of in vivo immunity. Eur. J. Nutr. 55:1583–93
    [Google Scholar]
27. Di Gesso JL, Kerr JS, Zhang Q, Raheem S, Yalamanchili SK et al. 2015. Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Mol. Nutr. Food Res. 59:1143–54
    [Google Scholar]
28. Edwards M, Czank C, Woodward GM, Cassidy A, Kay CD 2015. Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function. J. Agric. Food Chem. 63:2423–31
    [Google Scholar]
29. Ertunc ME, Hotamisligil GS 2016. Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment. J. Lipid Res. 57:2099–114
    [Google Scholar]
30. Gabay C, Kushner I 1999. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340:448–54
    [Google Scholar]
31. Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM 2015. Advances in our understanding of oxylipins derived from dietary PUFAs. Adv. Nutr. 6:513–40
    [Google Scholar]
32. Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP 2006. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. Am. J. Clin. Nutr. 84:44–53
    [Google Scholar]
33. Hawley JA, Morton JP 2014. Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clin. Exp. Pharmacol. Physiol. 41:608–13
    [Google Scholar]
34. Heinonen I, Saltin B, Hellsten Y, Kalliokoski KK 2017. The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal muscles. Eur. J. Appl. Physiol. 117:1175–80
    [Google Scholar]
35. Hennigar SR, McClung JP, Pasiakos SM 2017. Nutritional interventions and the IL-6 response to exercise. FASEB J 31:3719–28
    [Google Scholar]
36. Hojman P 2017. Exercise protects from cancer through regulation of immune function and inflammation. Biochem. Soc. Trans. 45:905–11
    [Google Scholar]
37. Hotamisligil GS 2017. Foundations of immunometabolism and implications for metabolic health and disease. Immunity 47:406–20
    [Google Scholar]
38. Impey SG, Hearris MA, Hammond KM, Bartlett JD, Louis J et al. 2018. Fuel for the work required: a theoretical framework for carbohydrate periodization and the glycogen threshold hypothesis. Sports Med 48:1031–48
    [Google Scholar]
39. Ivey KL, Hodgson JM, Croft KD, Lewis JR, Prince RL 2015. Flavonoid intake and all-cause mortality. Am. J. Clin. Nutr. 101:1012–20
    [Google Scholar]
40. Kasuga K, Suga T, Mano N 2015. Bioanalytical insights into mediator lipidomics. J. Pharm. Biomed. Anal. 113:151–62
    [Google Scholar]
41. Kay CD 2015. Rethinking paradigms for studying mechanisms of action of plant bioactives. Nutr. Bull. 40:335–39
    [Google Scholar]
42. Kay CD, Pereira-Caro G, Ludwig IA, Clifford MN, Crozier A 2017. Anthocyanins and flavanones are more bioavailable than previously perceived: a review of recent evidence. Annu. Rev. Food Sci. Technol. 28:8155–80
    [Google Scholar]
43. Koelwyn GJ, Wennerberg E, Demaria S, Jones LW 2015. Exercise in regulation of inflammation-immune axis function in cancer initiation and progression. Oncology 29:908–20
    [Google Scholar]
44. Konrad M, Nieman DC, Henson DA, Kennerly KM, Jin F, Wallner-Liebmann SJ 2011. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int. J. Sport Nutr. Exerc. Metab. 21:338–46
    [Google Scholar]
45. Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM 2014. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers. Redox Biol 2:206–10
    [Google Scholar]
46. Kumar N, Gupta G, Anilkumar K, Fatima N, Karnati R et al. 2016. 15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome. Sci. Rep. 18:631649
    [Google Scholar]
47. Lehmann R, Zhao X, Weigert C, Simon P, Fehrenbach E et al. 2010. Medium-chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PLOS ONE 5:e11519
    [Google Scholar]
48. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC et al. 2010. Metabolic signatures of exercise in human plasma. Sci. Transl. Med. 2:33ra37
    [Google Scholar]
49. Lila MA, Burton-Freeman B, Grace M, Kalt W 2016. Unraveling anthocyanin bioavailability for human health. Annu. Rev. Food Sci. Technol. 7:375–93
    [Google Scholar]
50. Lin XH, Xu MT, Tang JY, Mai LF, Wang XY et al. 2016. Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 in patients with newly diagnosed type 2 diabetes. Lipids Health Dis 15:203
    [Google Scholar]
51. Lu W, Su X, Klein MS, Lewis IA, Fiehn O, Rabinowitz JD 2017. Metabolite measurement: pitfalls to avoid and practices to follow. Annu. Rev. Biochem. 86:277–304
    [Google Scholar]
52. MacLaren DP, Reilly T, Campbell IT, Frayn KN 1994. Hormonal and metabolite responses to glucose and maltodextrin ingestion with or without the addition of guar gum. Int. J. Sports Med. 15:466–71
    [Google Scholar]
53. Markworth JF, Kaur G, Miller EG, Larsen AE, Sinclair AJ et al. 2016.a Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid. FASEB J 30:3714–25
    [Google Scholar]
54. Markworth JF, Maddipati KR, Cameron-Smith D 2016.b Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury. Exerc. Immunol. Rev. 22:110–34
    [Google Scholar]
55. Markworth JF, Vella LD, Figueiredo VC, Cameron-Smith D 2014. Ibuprofen treatment blunts early translational signaling responses in human skeletal muscle following resistance exercise. J. Appl. Physiol. 117:20–28
    [Google Scholar]
56. Markworth JF, Vella L, Lingard BS, Tull DL, Rupasinghe TW et al. 2013. Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305:R1281–96
    [Google Scholar]
57. Mathis D, Shoelson SE 2011. Immunometabolism: an emerging frontier. Nat. Rev. Immunol. 11:81
    [Google Scholar]
58. McCartney D, Desbrow B, Irwin C 2018. Post-exercise ingestion of carbohydrate, protein and water: a systematic review and meta-analysis for effects on subsequent athletic performance. Sports Med 48:379–408
    [Google Scholar]
59. Mika A, Sledzinski T 2017. Alterations of specific lipid groups in serum of obese humans: a review. Obes. Rev. 18:247–72
    [Google Scholar]
60. Mitchell JB, Pizza FX, Paquet A, Davis BJ, Forrest MB, Braun WA 1998. Influence of carbohydrate status on immune responses before and after endurance exercise. J. Appl. Physiol. 84:1917–25
    [Google Scholar]
61. Mortensen OH, Andersen K, Fischer C, Nielsen AR, Nielsen S et al. 2008. Calprotectin is released from human skeletal muscle tissue during exercise. J. Physiol. 586:3551–62
    [Google Scholar]
62. Müller L, Pawelec G 2014. Aging and immunity: impact of behavioral intervention. Brain Behav. Immun. 39:8–22
    [Google Scholar]
63. Myburgh KH 2014. Polyphenol supplementation: benefits for exercise performance or oxidative stress. Sports Med 44:Suppl. 1S57–70
    [Google Scholar]
64. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE et al. 1997. Carbohydrate and the cytokine response to 2.5 h of running. J. Appl. Physiol. 82:1662–67
    [Google Scholar]
65. Nieman DC 1998. Influence of carbohydrate on the immune response to intensive, prolonged exercise. Exerc. Immunol. Rev. 4:64–76
    [Google Scholar]
66. Nieman DC 2000. Is infection risk linked to exercise workload. Med. Sci. Sports Exerc. 32:Suppl. 7S406–11
    [Google Scholar]
67. Nieman DC 2008. Immunonutrition support for athletes. Nutr. Rev. 66:310–20
    [Google Scholar]
68. Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M et al. 2003. Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J. Appl. Physiol. 94:1917–25
    [Google Scholar]
69. Nieman DC, Fagoaga OR, Butterworth DE, Warren BJ, Utter A et al. 1997. Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 2.5 h or running. Am. J. Clin. Nutr. 66:153–59
    [Google Scholar]
70. Nieman DC, Gillitt ND, Henson DA, Sha W, Shanely RA et al. 2012. Bananas as an energy source during exercise: a metabolomics approach. PLOS ONE 7:e37479
    [Google Scholar]
71. Nieman DC, Gillitt ND, Knab AM, Shanely RA, Pappan KL, Jin F, Lila MA 2013.a Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach. PLOS ONE 8:e72215
    [Google Scholar]
72. Nieman DC, Gillitt ND, Sha W, Esposito D, Ramamoorthy S 2018.a Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: a randomized, crossover trial. PLOS ONE 13:e0194843
    [Google Scholar]
73. Nieman DC, Gillitt ND, Sha W, Meaney MP, John C, Pappan KL, Kinchen JM 2015.a Metabolomics-based analysis of banana and pear ingestion on exercise performance and recovery. J. Proteome Res. 14:5367–77
    [Google Scholar]
74. Nieman DC, Groen A, Pugachev A, Vacca G 2018.b Detection of functional overreaching in endurance athletes using proteomics. Proteomes 6:33
    [Google Scholar]
75. Nieman DC, Henson DA, Austin MD, Brown VA 2005. Immune response to a 30-min walk. Med. Sci. Sports. Exerc. 37:57–62
    [Google Scholar]
76. Nieman DC, Henson DA, Austin MD, Sha W 2011. Upper respiratory tract infection is reduced in physically fit and active adults. Br. J. Sports. Med. 45:987–92
    [Google Scholar]
77. Nieman DC, Henson DA, Gojanovich G, Davis JM, Murphy EA et al. 2006. Influence of carbohydrate on immune function following 2 h cycling. Res. Sports. Med. 14:225–37
    [Google Scholar]
78. Nieman DC, Henson DA, McAnulty SR, Jin F, Maxwell KR 2009. n-3 polyunsaturated fatty acids do not alter immune and inflammation measures in endurance athletes. Int. J. Sport Nutr. Exerc. Metab. 19:536–46
    [Google Scholar]
79. Nieman DC, Johanssen LM, Lee JW, Arabatzis K 1990. Infectious episodes in runners before and after the Los Angeles Marathon. J. Sports Med. Phys. Fitness 30:316–28
    [Google Scholar]
80. Nieman DC, Luo B, Dréau D, Henson DA, Shanely RA et al. 2014.a Immune and inflammation responses to a 3-day period of intensified running versus cycling. Brain. Behav. Immun. 39:180–85
    [Google Scholar]
81. Nieman DC, Meaney MP, John CS, Knagge KJ, Chen H 2016. 9- and 13-Hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2h running. Brain Behav. Immun. 56:246–52
    [Google Scholar]
82. Nieman DC, Mitmesser SH 2017. Potential impact of nutrition on immune system recovery from heavy exertion: a metabolomics perspective. Nutrients 9:5e513
    [Google Scholar]
83. Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR, Henson DA, Utter A et al. 1998. Influence of mode and carbohydrate on the cytokine response to heavy exertion. Med. Sci. Sports Exerc. 30:671–78
    [Google Scholar]
84. Nieman DC, Ramamoorthy S, Kay CD, Goodman CL, Capps CR et al. 2017.a Influence of ingesting a flavonoid-rich supplement on the metabolome and concentration of urine phenolics in overweight/obese women. J. Proteome Res. 16:2924–35
    [Google Scholar]
85. Nieman DC, Scherr J, Luo B, Meaney MP, Dréau D et al. 2014.b Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial. PLOS ONE 9:e113725
    [Google Scholar]
86. Nieman DC, Sha W, Pappan KL 2017.b IL-6 linkage to exercise-induced shifts in lipid-related metabolites: a metabolomics-based analysis. J. Proteome Res. 16:970–7
    [Google Scholar]
87. Nieman DC, Shanely RA, Gillitt ND, Pappan KL, Lila MA 2013.b Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners. J. Proteome Res. 12:4577–84
    [Google Scholar]
88. Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL 2014.c Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307:R68–74
    [Google Scholar]
89. Nieman DC, Zwetsloot KA, Meaney MP, Lomiwes DD, Hurst SM, Hurst RD 2015.b Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression. Front. Nutr. 2:27
    [Google Scholar]
90. O'Gorman A, Brennan L 2017. The role of metabolomics in determination of new dietary biomarkers. Proc. Nutr. Soc. 76:295–302
    [Google Scholar]
91. O'Neill LA, Pearce EJ 2016. Immunometabolism governs dendritic cell and macrophage function. J. Exp. Med. 213:15–23
    [Google Scholar]
92. Ostermann AI, Schebb NH 2017. Effects of omega-3 fatty acid supplementation on the pattern of oxylipins: a short review about the modulation of hydroxy-, dihydroxy-, and epoxy-fatty acids. Food Funct 8:2355–67
    [Google Scholar]
93. Patel JJ, Hurt RT, McClave SA, Martindale RG 2017. Critical care nutrition: Where's the evidence. Crit. Care Clin. 33:397–412
    [Google Scholar]
94. Peake JM, Neubauer O, Della Gatta PA, Nosaka K 2017. Muscle damage and inflammation during recovery from exercise. J. Appl. Physiol. 122:559–70
    [Google Scholar]
95. Powell WS, Rokach J 2015. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid. Biochim. Biophys. Acta. 1851:340–55
    [Google Scholar]
96. Pyne DB, Smith JA, Baker MS, Telford RD, Weidemann MJ 2000. Neutrophil oxidative activity is differentially affected by exercise intensity and type. J. Sci. Med. Sport 3:44–54
    [Google Scholar]
97. Ramsden CE, Ringel A, Feldstein AE, Taha AY, MacIntosh BA et al. 2012. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot. Essent. Fatty Acids 87:135–41
    [Google Scholar]
98. Rangel-Huerta OD, Aguilera CM, Perez-de-la-Cruz A, Vallejo F, Tomas-Barberan F et al. 2017. A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study. Mol. Nutr. Food Res. https://doi.org/10.1002/mnfr.201600120
    [Crossref]
99. Rietschier HL, Henagan TM, Earnest CP, Baker BL, Cortez CC, Stewart LK 2011. Sun-dried raisins are a cost-effective alternative to Sports Jelly Beans in prolonged cycling. J. Strength Cond. Res. 25:3150–56
    [Google Scholar]
100. Rothwell JA, Perez-Jimenez J, Neveu V, Medina-Remón A, M'hiri N et al. 2013. Phenol-Explorer 3.0: a major update of the phenol-explorer database to incorporate data on the effects of food processing on polyphenol content. Database 2013:bat070
     [Google Scholar]
101. Santos VC, Sierra AP, Oliveira R, Caçula KG, Momesso CM et al. 2016. Marathon race affects neutrophil surface molecules: role of inflammatory mediators. PLOS ONE 11:e0166687
     [Google Scholar]
102. Serhan CN 2014. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510:92–101
     [Google Scholar]
103. Serhan CN 2017. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. FASEB J 31:1273–88
     [Google Scholar]
104. Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N 2015. Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim. Biophys. Acta. 1851:397–413
     [Google Scholar]
105. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK et al. 2012. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J 26:1755–65
     [Google Scholar]
106. Shanely RA, Nieman DC, Henson DA, Jin F, Knab AM, Sha W 2013. Inflammation and oxidative stress are lower in physically fit and active adults. Scand. J. Med. Sci. Sports. 23:215–23
     [Google Scholar]
107. Shanely RA, Nieman DC, Perkins-Veazie P, Henson DA, Meaney MP et al. 2016. Comparison of watermelon and carbohydrate beverage on exercise-induced alterations in systemic inflammation, immune dysfunction, and plasma antioxidant capacity. Nutrients 8:8e518
     [Google Scholar]
108. Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM et al. 2017. Sugar or fat?—Metabolic requirements for immunity to viral infections. Front. Immunol. 8:1311
     [Google Scholar]
109. Siedlik JA, Benedict SH, Landes EJ, Weir JP, Vardiman JP, Gallagher PM 2016. Acute bouts of exercise induce a suppressive effect on lymphocyte proliferation in human subjects: A meta-analysis. Brain Behav. Immun. 56:343–51
     [Google Scholar]
110. Simpson RJ, Lowder TW, Spielmann G, Bigley AB, LaVoy EC, Kunz H 2012. Exercise and the aging immune system. Ageing Res. Rev. 11:404–20
     [Google Scholar]
111. Somerville VS, Braakhuis AJ, Hopkins WG 2016. Effect of flavonoids on upper respiratory tract infections and immune function: a systematic review and meta-analysis. Adv. Nutr. 7:488–97
     [Google Scholar]
112. Spriet LL 2014. New insights into the interaction of carbohydrate and fat metabolism during exercise. Sports Med 44:Suppl. 1S87–96
     [Google Scholar]
113. Srisawat K, Shepherd SO, Lisboa PJ, Burniston JG 2017. A systematic review and meta-analysis of proteomics literature on the response of human skeletal muscle to obesity/type 2 diabetes mellitus (T2DM) versus exercise training. Proteomes 5:4e30
     [Google Scholar]
114. Tolstikov V 2016. Metabolomics: bridging the gap between pharmaceutical development and population health. Metabolites 6:3e20
     [Google Scholar]
115. Toscano LT, Tavares RL, Toscano LT, Silva CS, Almeida AE et al. 2015. Potential ergogenic activity of grape juice in runners. Appl. Physiol. Nutr. Metab. 40:899–906
     [Google Scholar]
116. Trappe TA, Liu SZ 2013. Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise. J. Appl. Physiol. 115:909–19
     [Google Scholar]
117. Trappe TA, Standley RA, Jemiolo B, Carroll CC, Trappe SW 2013. Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304:R198–205
     [Google Scholar]
118. Turner JE 2016. Is immunosenescence influenced by our lifetime “dose” of exercise. Biogerontology 17:581–602
     [Google Scholar]
119. Vandenbogaerde TJ, Hopkins WG 2011. Effects of acute carbohydrate supplementation on endurance performance: a meta-analysis. Sports Med 41:773–92
     [Google Scholar]
120. Van den Bossche J, O'Neill LA, Menon D 2017. Macrophage immunometabolism: Where are we (going). Trends Immunol 38:395–406
     [Google Scholar]
121. van Dijk JG, Matson KD 2016. Ecological immunology through the lens of exercise immunology: new perspective on the links between physical activity and immune function and disease susceptibility in wild animals. Integr. Comp. Biol. 56:290–303
     [Google Scholar]
122. Vangaveti VN, Jansen H, Kennedy RL, Malabu UH 2016. Hydroxyoctadecadienoic acids: oxidized derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer. Eur. J. Pharmacol. 785:70–76
     [Google Scholar]
123. Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS et al. 2011. Position statement. Part two: maintaining immune health. Exerc. Immunol. Rev. 17:64–103
     [Google Scholar]
124. Wang X, Ouyang YY, Liu J, Zhao G 2014. Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br. J. Nutr. 111:1–11
     [Google Scholar]
125. Warner EF, Smith MJ, Zhang Q, Raheem KS, O'Hagan D et al. 2017. Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Mol. Nutr. Food Res. https://doi.org/10.1002/mnfr.201700053
     [Crossref]
126. Wedell-Neergaard AS, Eriksen L, Grønbæk M, Pedersen BK, Krogh-Madsen R, Tolstrup J 2018. Low fitness is associated with abdominal adiposity and low-grade inflammation independent of BMI. PLOS ONE 13:e0190645
     [Google Scholar]
127. Welsh RS, Davis JM, Burke JR, Williams HG 2002. Carbohydrates and physical/mental performance during intermittent exercise to fatigue. Med. Sci. Sports Exerc. 34:723–31
     [Google Scholar]
128. Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M et al. 2018. Extracellular vesicles provide a means for tissue crosstalk during exercise. Cell Metab 27:237–51
     [Google Scholar]
129. Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K et al. 2018. HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res 46:D1D608–17
     [Google Scholar]
130. Xu X, Li R, Chen G, Hoopes SL, Zeldin DC, Wang DW 2016. The role of cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids in metabolic diseases. Adv. Nutr. 7:1122–28
     [Google Scholar]
131. Ye RD, Sun L 2015. Emerging functions of serum amyloid A in inflammation. J. Leukoc. Biol. 98:923–29
     [Google Scholar]
132. Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, Li HB 2015. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20:21138–56
     [Google Scholar]
133. Zhao YY, Miao H, Cheng XL, Wei F 2015. Lipidomics: novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease. Chem. Biol. Interact. 240:220–38
     [Google Scholar]