1932

Abstract

Human breast milk is generally and universally recognized as the optimal choice for nutrition during the first year of life. In certain cases in which it is not feasible to breast-feed the infant or the breast milk is not sufficient, especially in the case of preterm infants, infant formula is the next best alternative to provide nutrition to nurture the infant. Therefore, it is highly important that the nutrient composition of the infant formula is as close to breast milk as possible for proper growth and development of the infant. However, human milk is a complex dynamic matrix, and therefore significant research has been done and is still ongoing to fully understand and mimic human breast milk, particularly its fat composition. Lipids play a critical role in infant nutrition. A number of advances have been made in infant formula lipid content and composition so that formula can better simulate or mimic the nutritional functions of human maternal milk.

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2016-02-28
2024-04-16
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Literature Cited

  1. Abrahamse E, Minekus M, van Aken GA, van de Heijning B, Knol J. et al. 2012. Development of the digestive system: experimental challenges and approaches of infant lipid digestion. Food Dig. 3:63–77 [Google Scholar]
  2. Am. Acad. Pediatr. Comm. Nutr 2002. New infant formula additives approved by FDA. AAP News 20:209–10 [Google Scholar]
  3. Anderson SA, Chinn HI, Fisher KD. 1982. History and current status of infant formulas. Am. J. Clin. Nutr. 35:381–97 [Google Scholar]
  4. Armand M, Hamosh M, Mehta NR, Angelus PA, Philpott JR. et al. 1996. Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatr. Res. 40:429–37 [Google Scholar]
  5. Barness LA. 1987. History of infant feeding practices. Am. J. Clin. Nutr. 46:168–70 [Google Scholar]
  6. Bar-on Z, Ben DG, Pelled D, Shulman A. 2005. Mimetic lipids and dietary supplements comprising the same. WIPO Patent No.2005051091 A8
  7. Bernbäck S, Bläckberg L, Hernell O. 1990. The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt–stimulated lipase. J. Clin. Investig. 85:1221–26 [Google Scholar]
  8. Bourlieu C, Michalski MC. 2015. Structure-function relationship of the milk fat globule. Curr. Opin. Clin. Nutr. Metab. Care 18:118–27 [Google Scholar]
  9. Braegger C, Chmielewska A, Decsi T, Kolacek S, Mihatsch W. et al. 2011. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J. Pediatr. Gastr. Nutr. 52:238–50 [Google Scholar]
  10. Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM. 2007. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am. J. Clin. Nutr. 85:1457–64 [Google Scholar]
  11. Bulstra-Ramakers MTEW, Huisjes HJ, Visser GHA. 1995. The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br. J. Obstet. Gynaecol. 102:123–26 [Google Scholar]
  12. CAC 1981. Standard for infant formula and formulas for special medical purposes intended for infants. Rome: FAO http://www.codexalimentarius.org/download/standards/288/CXS_072e.pdf
  13. Carnielli VP, Luijendijk IHT, Van Goudoever JB, Sulkers EJ, Boerlage AA. et al. 1995. Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance. Am. J. Clin. Nutr. 61:1037–42 [Google Scholar]
  14. Carnielli VP, Luijendijk IHT, Van Goudoever JB, Sulkers EJ, Boerlage AA. et al. 1996. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. J. Pediatr. Gastr. Nutr. 23:553–60 [Google Scholar]
  15. Castilho SD, Barros-Filho AA. 2014. Historical aspects of formula feeding. Handbook of Dietary and Nutritional Aspects of Bottle Feeding VR Preedy, RR Watson, S Zibadi 17–32 Wageningen, Neth: Wageningen Acad. Publ. [Google Scholar]
  16. Chen ZY, Kwan KY, Tong KK, Ratnayake WMN, Li HQ, Leung SSF. 1997. Breast milk fatty acid composition: a comparative study between Hong Kong and Chongqing Chinese. Lipids 32:1061–67 [Google Scholar]
  17. Chen ZY, Pelletier G, Hollywood R, Ratnayake WMN. 1995. Trans fatty-acid isomers in Canadian human milk. Lipids 30:15–21 [Google Scholar]
  18. Chumlea WC, Guo SS. 2005. Physical growth and development. Handbook of Pediatric Nutrition PQ Samour, KK Helm, CE Lang 4–5 Sudbury, MA: Jones & Bartlett Publ. [Google Scholar]
  19. Coletta JM, Bell SJ, Roman AS. 2010. Omega-3 fatty acids and pregnancy. Rev. Obstet. Gynecol. 3:163–71 [Google Scholar]
  20. Decker EA. 1996. The role of stereospecific saturated fatty acid positions on lipid nutrition. Nutr. Rev. 54:108–10 [Google Scholar]
  21. EC (Eur. Comm.) 2006. Commission Directive 2006/141/EC of 22 December 2006 on infant formulae and follow-on formulae and amending Directive 1999/21/EC Text with EEA relevance http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32006L0141&from=EN
  22. EFSA Panel Dietet. Prod. Nutr. Allerg 2011. Scientific Opinion on the substantiation of a health claim related to beta-palmitate and increased calcium absorption pursuant to Article 14 of Regulation (EC) No 1924/2006. Eur. Food Saf. Author. J. 9:2289–305 [Google Scholar]
  23. EFSA Panel Dietet. Prod. Nutr. Allerg 2014. Scientific Opinion on the substantiation of a health claim related to beta-palmitate and contribution to softening of stools pursuant to Article 14 of Regulation (EC) No 1924/2006. Eur. Food Saf. Author. J. 12:3578–92 [Google Scholar]
  24. FAO 2010. Fats and Fatty Acids in Human Nutrition: Report of an Expert Consultation Rome: FAO189
  25. FDA 1985. Code of Federal Regulations Title 21 Washington, DC: U.S. Dep. Agric http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=107.100
  26. German JB, Dillard CJ, Ward RE. 2002. Bioactive components in milk. Curr. Opin. Clin. Nutr. Metab. Care 5:653–58 [Google Scholar]
  27. Gibson RA, Kneebone GM. 1981. Fatty acid composition of human colostrum and mature breast-milk. Am. J. Clin. Nutr. 34:252–57 [Google Scholar]
  28. Greenberg MH. 1980. Neonatal feeding. Historical Review and Recent Advances in Neonatal and Perinatal Medicine GF Smith, D Vidyasagar Glenview, IL: Mead Johnson Nutr. Div http://www.neonatology.org/classics/mj1980/ch04.html [Google Scholar]
  29. Haddad I, Mozzon M, Frega NG. 2012. Trends in fatty acids positional distribution in human colostrum, transitional, and mature milk. Eur. Food Res. Technol. 235:325–32 [Google Scholar]
  30. Hagan JF, Shaw JS, Duncan PM. 2008. Bright Futures: Guidelines for Health Supervision of Infants, Children and Adolescents Elk Grove Village, IL: Am. Acad. Pediatr.
  31. Haggarty P, Page K, Abramovich DR, Ashton J, Brown D. 1997. Long-chain polyunsaturated fatty acid transport across the perfused human placenta. Placenta 18:635–42 [Google Scholar]
  32. Hamosh M, Peterson JA, Henderson TR, Scallan CD, Kiwan R. et al. 1999. Protective function of human milk: the milk fat globule. Semin. Perinatol. 23:242–49 [Google Scholar]
  33. Hayat L, Al-Sughayer M, Afzal M. 1999. A comparative study of fatty acids in human breast milk and breast milk substitutes in Kuwait. Nutr. Res. 19:827–41 [Google Scholar]
  34. Helland IB, Saugstad OD, Smith L, Saarem K, Solvoll K. et al. 2001. Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 108:e82 [Google Scholar]
  35. Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. 2003. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 111:e39–44 [Google Scholar]
  36. Herrera E. 2002. Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development: a review. Placenta 23:S9–19 [Google Scholar]
  37. Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I. et al. 2007. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369:578–85 [Google Scholar]
  38. Ilyasoglu H, Gultekin-Ozguven M, Ozcelik B. 2011. Production of human milk fat substitute with medium-chain fatty acids by lipase-catalyzed acidolysis: optimization by response surface methodology. LWT Food Sci. Technol. 44:999–1004 [Google Scholar]
  39. Innis SM. 2011. Dietary triacylglycerol structure and its role in infant nutrition. Adv. Nutr. 2:275–83 [Google Scholar]
  40. Isaacs JS. 2011. Infant nutrition. Nutrition Through the Life Cycle JE Brown, JS Issacs, UB Krinke, E Lechtenberg, MA Murtaugh, C Sharbaugh 222–46 Belmont, CA: Cengage [Google Scholar]
  41. Jenness R. 1979. The composition of human milk. Semin. Perinatol. 3:225–39 [Google Scholar]
  42. Jensen CL. 2006. Effects of n-3 fatty acids during pregnancy and lactation. Am. J. Clin. Nutr. 83:S1452–57 [Google Scholar]
  43. Jensen RG. 1996. The lipids in human milk. Prog. Lipid Res. 35:53–92 [Google Scholar]
  44. Jensen RG. 1999. Lipids in human milk. Lipids 34:1243–71 [Google Scholar]
  45. Jensen RG, Hagerty MM, McMahon KE. 1978. Lipids of human milk and infant formulas: a review. Am. J. Clin. Nutr. 31:990–1016 [Google Scholar]
  46. Kennedy K, Fewtrell MS, Morley R, Abbott R, Quinlan PT. et al. 1999. Double-blind, randomized trial of a synthetic triacylglycerol in formula-fed term infants: effects on stool biochemistry, stool characteristics, and bone mineralization. Am. J. Clin. Nutr. 70:920–27 [Google Scholar]
  47. Kidd PM. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern. Med. Rev. 12:207–227 [Google Scholar]
  48. King DM, Padley FB. 1989. Substitute milk fat compositions. US Patent No. 4876107
  49. Koletzko B, Baker S, Cleghorn G, Neto UF, Gopalan S. et al. 2005. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J. Pediatr. Gastr. Nutr. 41:584–99 [Google Scholar]
  50. Koletzko B, Lien E, Agostoni C, Böhles H, Campoy C. et al. 2008. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J. Perinat. Med. 36:5–14 [Google Scholar]
  51. Lien EL. 1994. The role of fatty acid composition and positional distribution in fat absorption in infants. J. Pediatr. 125:S62–68 [Google Scholar]
  52. Litmanovitz I, Bar-Yoseph F, Lifshitz Y, Davidson K, Eliakim A. et al. 2014. Reduced crying in term infants fed high beta-palmitate formula: a double-blind randomized clinical trial. BMC Pediatr. 14:152–57 [Google Scholar]
  53. Litmanovitz I, Davidson K, Eliakim A, Regev RH, Dolfin T. et al. 2013. High beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcif. Tissue Int. 92:35–41 [Google Scholar]
  54. Long AC, Kaiser JL, Katz GE. 2013. Lipids in infant formulas: current and future innovations. Lipid Technol. 25:127–29 [Google Scholar]
  55. Lopez C. 2011. Milk fat globules enveloped by their biological membrane: unique colloidal assemblies with a specific composition and structure. Curr. Opin. Colloid Interface Sci. 16:391–404 [Google Scholar]
  56. Lopez C, Menard O. 2011. Human milk fat globules: polar lipid composition and in situ structural investigations revealing the heterogeneous distribution of proteins and the lateral segregation of sphingomyelin in the biological membrane. Colloid Surf. B. 83:29–41 [Google Scholar]
  57. Lopez-Lopez A, Castellote-Bargallo AI, Campoy-Folgoso C, Rivero-Urgell M, Tormo-Carnice R. et al. 2001. The influence of dietary palmitic acid triacylglyceride position on the fatty acid, calcium and magnesium contents of at term newborn faeces. Early Hum. Dev. 65:S83–94 [Google Scholar]
  58. Lopez-Lopez A, Lopez-Sabater MC, Campoy-Folgoso C, Rivero-Urgell M, Castellote-Bargallo AL. 2002. Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. Eur. J. Clin. Nutr. 56:1242–54 [Google Scholar]
  59. Lucas A, Quinlan P, Abrams S, Ryan S, Meah S, Lucas PJ. 1997. Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants. Arch. Dis. Child. 77:F178–84 [Google Scholar]
  60. Maduko CO, Park YW, Akoh CC. 2008. Characterization and oxidative stability of structured lipids: infant milk fat analog. J. Am. Oil Chem. Soc. 85:197–204 [Google Scholar]
  61. Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J. et al. 2010. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. J. Am. Med. Assoc. 304:1675–83 [Google Scholar]
  62. Marin MC, Sanjurjo A, Rodrigo MA, de Alaniz MJT. 2005. Long-chain polyunsaturated fatty acids in breast milk in La Plata, Argentina: relationship with maternal nutritional status. Prostag. Leukotr. Ess. 73:355–60 [Google Scholar]
  63. Martinez JA, Ballew MP. 2011. Infant formulas. Pediatr. Rev. 32:179–89 [Google Scholar]
  64. Martinez M. 1992. Tissue levels of polyunsaturated fatty acids during early human development. J. Pediatr. 120:S129–38 [Google Scholar]
  65. Michalski MC. 2013. Lipids and milk fat globule properties in human milk. Handbook of Dietary and Nutritional Aspects of Human Breast Milk S Zibadi, RR Watson, VR Preedy 315–34 Wageningen, Neth.: Wageningen Acad. Publ. [Google Scholar]
  66. Michalski MC, Briard V, Michel F, Tasson F, Poulain P. 2005. Size distribution of fat globules in human colostrum, breast milk, and infant formula. J. Dairy Sci. 88:1927–40 [Google Scholar]
  67. Morera Pons S, Castellote Bargallo A, Campoy Folgoso C, Lopez Sabater MC. 2000. Triacylglycerol composition in colostrum, transitional and mature human milk. Eur. J. Clin. Nutr. 54:878–82 [Google Scholar]
  68. Nagachinta S, Akoh CC. 2012. Enrichment of palm olein with long chain polyunsaturated fatty acids by enzymatic acidolysis. LWT Food Sci. Technol. 46:29–35 [Google Scholar]
  69. Nagachinta S, Akoh CC. 2013. Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. J. Food Sci. 78:C1523–28 [Google Scholar]
  70. Nesheim MC, Yaktine AL. 2007. Seafood Choices: Balancing Benefits and Risks Washington, DC: Natl. Acad. Press
  71. NRC (Natl. Res. Counc.) 2006. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements Washington, DC: Natl. Acad. Press
  72. Oken E, Bellinger DC. 2008. Fish consumption, methylmercury and child neurodevelopment. Curr. Opin. Pediatr. 20:178–83 [Google Scholar]
  73. Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C. 2000. Randomized clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials in Pregnancy (FOTIP) Team. BJOG Int. J. Obstet. Gynaecol. 107:382–95 [Google Scholar]
  74. Olsen SF, Sørensen JD, Secher NJ, Hedegaard M, Henriksen TB. et al. 1992. Randomized controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 339:1003–7 [Google Scholar]
  75. Oosting A, Engels E, Kegler D, Abrahamse M, Teller I, van der Beek E. 2011. A more breast milk-like infant formula reduces excessive body fat accumulation in adult mice. Pediatr. Res. 70:837 [Google Scholar]
  76. Oosting A, Kegler D, Wopereis HJ, Teller IC, van de Heijning BJM. et al. 2012. Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood. Pediatr. Res. 72:362–69 [Google Scholar]
  77. Pande G, Sabir JSM, Baeshen NA, Akoh CC. 2013. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. J. Agr. Food Chem. 61:10590–98 [Google Scholar]
  78. Pina-Rodriguez AM, Akoh CC. 2009. Synthesis and characterization of a structured lipid from amaranth oil as a partial fat substitute in milk-based infant formula. J. Agr. Food Chem. 57:6748–56 [Google Scholar]
  79. Ramakrishnan U, Stein AD, Parra-Cabrera S, Wang M, Imhoff-Kunsch B. et al. 2010. Effects of docosohexaenoic acid supplementation during pregnancy on gestational age and size at birth; randomized, double-blind, placebo controlled trial in Mexico. Food Nutr. Bull. 31:S108–16 [Google Scholar]
  80. Riordan J. 2005. The biological specificity of breastmilk. Breastfeeding and Human Lactation J. Riordan 97–136 Sudbury, MA: Jones & Bartlett Publ. [Google Scholar]
  81. Rocquelin G, Tapsoba S, Dop MC, Mbemba F, Traissac P, Martin-Prevel Y. 1998. Lipid content and essential fatty acid (EFA) composition of mature Congolese breast milk are influenced by mothers' nutritional status: impact on infants' EFA supply. Eur. J. Clin. Nutr. 52:164–71 [Google Scholar]
  82. Roman C, Carrière F, Villeneuve P, Pina M, Millet V. et al. 2007. Quantitative and qualitative study of gastric lipolysis in premature infants: Do MCT-enriched infant formulas improve fat digestion?. Pediatr. Res. 61:83–88 [Google Scholar]
  83. Sahin N, Akoh CC, Karaali A. 2005. Enzymatic production of human milk fat substitutes containing gamma-linolenic acid: optimization of reactions by response surface methodology. J. Am. Oil Chem. Soc. 82:549–57 [Google Scholar]
  84. Sala-Vila A, Castellote AI, Rodriguez-Palmero M, Campoy C, Lopez-Sabater MC. 2005. Lipid composition in human breast milk from Granada (Spain): changes during lactation. Nutrition 21:467–73 [Google Scholar]
  85. Samur G, Topcu A, Turan S. 2009. Trans fatty acids and fatty acid composition of mature breast milk in Turkish women and their association with maternal diets. Lipids 44:405–13 [Google Scholar]
  86. Schmid U, Bornscheuer UT, Soumanou MM, McNeill GP, Schmid RD. 1999. Highly selective synthesis of 1,3-oleoyl-2-palmitoylglycerol by lipase catalysis. Biotechnol. Bioeng. 64:678–84 [Google Scholar]
  87. Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A. 2010. Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur. J. Pediatr. 169:149–64 [Google Scholar]
  88. Schuman AJ. 2003. A concise history of infant formula (twist and turns included). Contemp. Pediatr. 20:91–103 [Google Scholar]
  89. Sidnell A, Greenstreet E. 2011. Infant nutrition-review of lipid innovation in infant formula. Nutr. Bull. 36:373–80 [Google Scholar]
  90. Silva MHL, Silva MTC, Brandao SCC, Gomes JC, Peternelli LA, Franceschini SD. 2005. Fatty acid composition of mature breast milk in Brazilian women. Food Chem. 93:297–303 [Google Scholar]
  91. Smit EN, Martini IA, Mulder H, Boersma ER, Muskiet FAJ. 2002. Estimated biological variation of the mature human milk fatty acid composition. Prostag. Leukotr. Ess. 66:549–55 [Google Scholar]
  92. Soumanou MM, Perignon M, Villeneuve P. 2013. Lipase-catalyzed interesterification reactions for human milk fat substitutes production: a review. Eur. J. Lipid Sci. Technol. 115:270–85 [Google Scholar]
  93. Sørensen ADM, Xu XB, Zhang L, Kristensen JB, Jacobsen C. 2010. Human milk fat substitute from butterfat: production by enzymatic interesterification and evaluation of oxidative stability. J. Am. Oil Chem. Soc. 87:185–94 [Google Scholar]
  94. Stam J, Sauer PJJ, Boehm G. 2013. Can we define an infant's need from the composition of human milk?. Am. J. Clin. Nutr. 98:521S–28 [Google Scholar]
  95. Stevens EE, Patrick TE, Pickler R. 2009. A history of infant feeding. J. Perinat. Educ. 18:32–39 [Google Scholar]
  96. Straarup EM, Lauritzen L, Faerk J, Høy CE, Michaelsen KF. 2006. The stereospecific triacylglycerol structures and fatty acid profiles of human milk and infant formulas. J. Pediatr. Gastr. Nutr. 42:293–99 [Google Scholar]
  97. Tecelao C, Rivera I, Sandoval G, Ferreira-Dias S. 2012. Carica papaya latex: a low-cost biocatalyst for human milk fat substitutes production. Eur. J. Lipid Sci. Technol. 114:266–76 [Google Scholar]
  98. Thomas DW, Greer FR, Comm N. 2010. Clinical report—probiotics and prebiotics in pediatrics. Pediatrics 126:1217–31 [Google Scholar]
  99. Trahms CM, McKean KN. 2008. Nutrition during infancy. Krause's Food & Nutrition Therapy LK Mahan, S Escott-Stump 199–221 St. Louis, MO: Elsevier Saunders [Google Scholar]
  100. Van Aerde JE, Feldman M, Clandinin MT. 1998. Accretion of lipid in the fetus and newborn. Fetal and Neonatal Physiology RA Polin, WW Fox 458–477 Philadelphia: W.B. Saunders Co. [Google Scholar]
  101. Vanderhoof J, Berseth CL. 2005. Growth during the first year of life. Perinatal Nutrition. Optimizing Infant Health and Development J Bhatia 291–98 New York: Marcel Dekker [Google Scholar]
  102. VanderJagt DJ, Arndt CD, Okolo SN, Huang YS, Chuang LT, Glew RH. 2000. Fatty acid composition of the milk lipids of Fulani women and the serum phospholipids of their exclusively breast-fed infants. Early Hum. Dev. 60:73–87 [Google Scholar]
  103. Yang TK, Fruekilde MB, Xu XB. 2003a. Applications of immobilized Thermomyces lanuginosa lipase in interesterification. J. Am. Oil Chem. Soc. 80:881–87 [Google Scholar]
  104. Yang TK, Xu XB, He C, Li LT. 2003b. Lipase-catalyzed modification of lard to produce human milk fat substitutes. Food Chem. 80:473–81 [Google Scholar]
  105. Yao M, Lien EL, Capeding MRZ, Fitzgerald M, Ramanujam K. et al. 2014. Effects of term infant formulas containing high sn-2 palmitate with and without oligofructose on stool composition, stool characteristics, and bifidogenicity. J. Pediatr. Gastr. Nutr. 59:440–48 [Google Scholar]
  106. Yaron S, Shachar D, Abramas L, Riskin A, Bader D. et al. 2013. Effect of high beta-palmitate content in infant formula on the intestinal microbiota of term infants. J. Pediatr. Gastr. Nutr. 56:376–81 [Google Scholar]
  107. Yehuda S, Rabinovitz S, Mostofsky DI. 2005. Essential fatty acids and the brain: from infancy to aging. Neurobiol. Aging 26:98–102 [Google Scholar]
  108. Yuhas R, Pramuk K, Lien EL. 2006. Human milk fatty acid composition from nine countries varies most in DHA. Lipids 41:851–58 [Google Scholar]
  109. Zou L. 2014. Enzymatic synthesis and application of structured lipids for infant formula PhD Thesis, Univ. Ga., Athens
  110. Zou L, Akoh CC. 2013a. Characterisation and optimisation of physical and oxidative stability of structured lipid-based infant formula emulsion: effects of emulsifiers and biopolymer thickeners. Food Chem. 141:2486–94 [Google Scholar]
  111. Zou L, Akoh CC. 2013b. Identification of tocopherols, tocotrienols, and their fatty acid esters in residues and distillates of structured lipids purified by short-path distillation. J. Agr. Food Chem. 61:238–46 [Google Scholar]
  112. Zou L, Akoh CC. 2015. Oxidative stability of structured lipid-based infant formula emulsion: effect of antioxidants. Food Chem. 178:1–9 [Google Scholar]
  113. Zou XQ, Huang JH, Jin QZ, Guo Z, Liu YF. et al. 2013. Model for human milk fat substitute evaluation based on triacylglycerol composition profile. J. Agr. Food Chem. 61:167–75 [Google Scholar]
  114. Zou XQ, Huang JH, Jin QZ, Liu YF, Song ZH, Wang XG. 2011. Lipase-catalyzed preparation of human milk fat substitutes from palm stearin in a solvent-free system. J. Agr. Food Chem. 59:6055–63 [Google Scholar]
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