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Annual Review of Medicine

Volume 67, 2016

Vitamin D and Cardiovascular Disease

Abstract

Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been consistently associated with an increased risk for cardiovascular disease and hypertension. Disruption of vitamin D signaling in animal models promotes hypertension, cardiac hypertrophy, and atherosclerosis. This evidence has led to the initiation of prospective randomized trials of vitamin D supplementation in individuals at risk for cardiovascular disease. The results of these trials should help to guide strategies for screening and management of vitamin D deficiency in the clinic and at the population level.

Keyword(s): cardiovascular disease, prevention, vitamin D
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2016-01-14
2024-04-23
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Vitamin D and Cardiovascular Disease
Annual Review of Medicine 67, 261 (2016); https://doi.org/10.1146/annurev-med-051214-025146
/content/journals/10.1146/annurev-med-051214-025146
/content/journals/10.1146/annurev-med-051214-025146
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