Novel Latency Reversal Agents for HIV-1 Cure

Figure 1: The role of IL-2 in the immune response. IL-2 signaling is mediated by different IL-2R configurations that are expressed by different immune cells. The high-affinity IL-2 receptor, IL-2Rαβγc...

Figure 2: Mechanism of action of IL-2 agents for the treatment of cancer and autoimmune diseases. (a) Cancer can be treated using agents that target the intermediate-affinity IL-2Rβγc receptor that is...

Figure 1: Schematic illustration of the cross-talk between the unfolded protein response (UPR), mitochondria, autophagy, and inflammatory and cell death pathways. In response to cellular stress, unfol...

Figure 2: Maladaptive repair following acute kidney injury (AKI) leads to chronic kidney disease (CKD). In response to acute injury, there is activation of cellular stress responses, cell death pathwa...

Figure 1: IL-11 is secreted from polarized cells or fibroblasts in response to injury and has autocrine and paracrine action. In polarized cells, IL-11 causes cellular dysfunction and can initiate apo...