Engineering Plant Disease Resistance Based on TAL Effectors

Annual Review of Phytopathology

Vol. 51:383-406 (Volume publication date August 2013)
https://doi.org/10.1146/annurev-phyto-082712-102255

Abstract

Transcription activator-like (TAL) effectors are encoded by plant-pathogenic bacteria and induce expression of plant host genes. TAL effectors bind DNA on the basis of a unique code that specifies binding of amino acid residues in repeat units to particular DNA bases in a one-to-one correspondence. This code can be used to predict binding sites of natural TAL effectors and to design novel synthetic DNA-binding domains for targeted genome manipulation. Natural mechanisms of resistance in plants against TAL effector–containing pathogens have given insights into new strategies for disease control.

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