1932

Abstract

The field of environmental health has been dominated by modeling associations, especially by regressing an observed outcome on a linear or nonlinear function of observed covariates. Readers interested in advances in policies for improving environmental health are, however, expecting to be informed about health effects resulting from, or more explicitly caused by, environmental exposures. The quantification of health impacts resulting from the removal of environmental exposures involves causal statements. Therefore, when possible, causal inference frameworks should be considered for analyzing the effects of environmental exposures on health outcomes.

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2019-04-01
2024-04-23
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Literature Cited

  1. 1. 
    Baccini M, Mattei A, Mealli F, Bertazzi PA, Carugno M 2017. Assessing the short term impact of air pollution on mortality: a matching approach. Environ. Health 16:7
    [Google Scholar]
  2. 2. 
    Balte P, Kühr J, Kruse H, Karmaus W 2017. Body burden of dichlorodiphenyl dichloroethene (DDE) and childhood pulmonary function. Int. J. Environ. Res. Public Health 14:111376
    [Google Scholar]
  3. 3. 
    Beckerman BS, Jerrett M, Finkelstein M, Kanaroglou P, Brook JR et al. 2012. The association between chronic exposure to traffic-related air pollution and ischemic heart disease. J. Toxicol. Environ. Health A 75:402–11
    [Google Scholar]
  4. 4. 
    Bind MA, Coull BA, Peters A, Baccarelli AA, Tarantini L et al. 2015. Beyond the mean: quantile regression to explore the association of air pollution with gene-specific methylation in the Normative Aging Study. Environ. Health Perspect. 123:759–65
    [Google Scholar]
  5. 5. 
    Bind MA, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A et al. 2014. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics 9:448–58
    [Google Scholar]
  6. 6. 
    Bind MA, Rubin DB 2017. Bridging observational studies and randomized experiments by embedding the former in the latter. Stat. Methods Med. Res.962280217740609
  7. 7. 
    Bind MA, Vanderweele TJ, Coull BA, Schwartz JD 2016. Causal mediation analysis for longitudinal data with exogenous exposure. Biostatistics 17:122–34
    [Google Scholar]
  8. 8. 
    Bind MA, VanderWeele TJ, Schwartz JD, Coull BA 2017. Quantile causal mediation analysis allowing longitudinal data. Stat. Med. 36:4182–95
    [Google Scholar]
  9. 9. 
    Brauer C, Budtz-Jørgensen E, Mikkelsen S 2008. Structural equation analysis of the causal relationship between health and perceived indoor environment. Int. Arch. Occup. Environ. Health 81:769–76
    [Google Scholar]
  10. 10. 
    Brook RD 2007. Is air pollution a cause of cardiovascular disease? Updated review and controversies. Rev. Environ. Health 22:115–37
    [Google Scholar]
  11. 11. 
    Bruce N, Neufeld L, Boy E, West C 1998. Indoor biofuel air pollution and respiratory health: the role of confounding factors among women in highland Guatemala. Int. J. Epidemiol. 27:454–58
    [Google Scholar]
  12. 12. 
    Chapin FS 1947. Experimental designs in sociological research New York: Harper
  13. 13. 
    Chen CWS, Hsieh YH, Su HC, Wu JJ 2018. Causality test of ambient fine particles and human influenza in Taiwan: age group-specific disparity and geographic heterogeneity. Environ. Int. 111:354–61
    [Google Scholar]
  14. 14. 
    Chen R, Meng X, Zhao A, Wang C, Yang C et al. 2016. DNA hypomethylation and its mediation in the effects of fine particulate air pollution on cardiovascular biomarkers: a randomized crossover trial. Environ. Int. 94:614–19
    [Google Scholar]
  15. 15. 
    Cochran WG 1953. Matching in analytical studies. Am. J. Public Health Nations Health 43:684–91
    [Google Scholar]
  16. 16. 
    Cochran WG 1968. The effectiveness of adjustment by subclassification in removing bias in observational studies. Biometrics 24:295–313
    [Google Scholar]
  17. 17. 
    Cochran WG, Chambers SP 1965. The planning of observational studies of human populations. J. R. Stat. Soc. Ser. A 128:234–66
    [Google Scholar]
  18. 18. 
    Cole-Hunter T, de Nazelle A, Donaire-Gonzalez D, Kubesch N, Carrasco-Turigas G et al. 2018. Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: a repeated measures study. Environ. Int. 111:247–59
    [Google Scholar]
  19. 19. 
    Cox B, Gasparrini A, Catry B, Fierens F, Vangronsveld J, Nawrot TS 2016. Ambient air pollution-related mortality in dairy cattle: Does it corroborate human findings?. Epidemiology 27:779–86
    [Google Scholar]
  20. 20. 
    Cox LA Jr., Popken DA 2015. Has reducing fine particulate matter and ozone caused reduced mortality rates in the United States?. Ann. Epidemiol. 25:162–73
    [Google Scholar]
  21. 21. 
    Cox LA Jr., Popken DA, Berman DW 2013. Causal versus spurious spatial exposure-response associations in health risk analysis. Crit. Rev. Toxicol. 43:Suppl. 126–38
    [Google Scholar]
  22. 22. 
    Cox LAT Jr. 2013. Caveats for causal interpretations of linear regression coefficients for fine particulate (PM2.5) air pollution health effects. Risk Anal 33:2111–25
    [Google Scholar]
  23. 23. 
    Cox LAT Jr. 2017. Do causal concentration-response functions exist? A critical review of associational and causal relations between fine particulate matter and mortality. Crit. Rev. Toxicol. 47:603–31
    [Google Scholar]
  24. 24. 
    Cox LAT Jr., Liu X, Shi L, Zu K, Goodman J 2017. Applying nonparametric methods to analyses of short-term fine particulate matter exposure and hospital admissions for cardiovascular diseases among older adults. Int. J. Environ. Res. Public Health 14:1051
    [Google Scholar]
  25. 25. 
    Cox T, Popken D, Ricci PF 2012. Temperature, not fine particulate matter (pm2.5), is causally associated with short-term acute daily mortality rates: results from one hundred United States cities. Dose Response 11:319–43
    [Google Scholar]
  26. 26. 
    Dehejia RH, Wahba S 1999. Causal effects in nonexperimental studies: reevaluating the evaluation of training programs. J. Am. Stat. Assoc. 94:1053–62
    [Google Scholar]
  27. 27. 
    Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A et al. 2009. Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms. Environ. Health Perspect. 117:1232–38
    [Google Scholar]
  28. 28. 
    Devlin RB, Duncan KE, Jardim M, Schmitt MT, Rappold AG, Diaz-Sanchez D 2012. Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation 126:104–11
    [Google Scholar]
  29. 29. 
    Devlin RB, Smith CB, Schmitt MT, Rappold AG, Hinderliter A et al. 2014. Controlled exposure of humans with metabolic syndrome to concentrated ultrafine ambient particulate matter causes cardiovascular effects. Toxicol. Sci. 140:61–72
    [Google Scholar]
  30. 30. 
    Diaz I, van der Laan MJ 2013. Assessing the causal effect of policies: an example using stochastic interventions. Int. J. Biostat. 9:161–74
    [Google Scholar]
  31. 31. 
    Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH et al. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329:1753–59
    [Google Scholar]
  32. 32. 
    Doll R, Hill AB 1954. The mortality of doctors in relation to their smoking habits; a preliminary report. BMJ 1:1451–55
    [Google Scholar]
  33. 33. 
    Dominici F, Peng RD, Zeger SL, White RH, Samet JM 2007. Particulate air pollution and mortality in the United States: Did the risks change from 1987 to 2000?. Am. J. Epidemiol. 166:880–88
    [Google Scholar]
  34. 34. 
    Dominici F, Zigler C 2017. Best practices for gauging evidence of causality in air pollution epidemiology. Am. J. Epidemiol. 186:1303–9
    [Google Scholar]
  35. 35. 
    Dunn C, Kingham S 1996. Establishing links between air quality and health: searching for the impossible?. Soc. Sci. Med. 42:831–41
    [Google Scholar]
  36. 36. 
    Ebenstein A, Fan M, Greenstone M, He G, Zhou M 2017. New evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River Policy. PNAS 114:10384–89
    [Google Scholar]
  37. 37. 
    Farhani S, Ozturk I 2015. Causal relationship between CO2 emissions, real GDP, energy consumption, financial development, trade openness, and urbanization in Tunisia. Environ. Sci. Pollut. Res. 22:15663–76
    [Google Scholar]
  38. 38. 
    Ferraro PJ, Hanauer MM 2014. Quantifying causal mechanisms to determine how protected areas affect poverty through changes in ecosystem services and infrastructure. PNAS 111:4332–37
    [Google Scholar]
  39. 39. 
    Fiorito G, Vlaanderen J, Polidoro S, Gulliver J, Galassi C et al. 2018. Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: a prospective study in nonsmokers. Environ. Mol. Mutagen. 59:234–46
    [Google Scholar]
  40. 40. 
    Flanders WD, Klein M, Darrow LA, Strickland MJ, Sarnat SE et al. 2011. A method for detection of residual confounding in time-series and other observational studies. Epidemiology 22:59–67
    [Google Scholar]
  41. 41. 
    Frangakis CE, Rubin DB 2002. Principal stratification in causal inference. Biometrics 58:21–29
    [Google Scholar]
  42. 42. 
    Gamble JF 1998. PM2.5 and mortality in long-term prospective cohort studies: cause-effect or statistical associations?. Environ. Health Perspect. 106:535–49
    [Google Scholar]
  43. 43. 
    Gamble JF, Lewis RJ 1996. Health and respirable particulate (PM10) air pollution: a causal or statistical association?. Environ. Health Perspect. 104:838–50
    [Google Scholar]
  44. 44. 
    Golan R, Kloog I, Almog R, Gesser-Edelsburg A, Negev M et al. 2018. Environmental exposures and fetal growth: the Haifa pregnancy cohort study. BMC Public Health 18:132
    [Google Scholar]
  45. 45. 
    Goldberg MS 2007. On the interpretation of epidemiological studies of ambient air pollution. J. Expo. Sci. Environ. Epidemiol. 17:Suppl. 266–70
    [Google Scholar]
  46. 46. 
    Goodman JE, Prueitt RL, Sax SN, Bailey LA, Rhomberg LR 2013. Evaluation of the causal framework used for setting national ambient air quality standards. Crit. Rev. Toxicol. 43:829–49
    [Google Scholar]
  47. 47. 
    Greenwood E 1945. Experimental Sociology: A Study in Method New York: Octogon Books King's Crown Press
  48. 48. 
    Griebel L, Prokosch HU, Köpcke F, Toddenroth D, Christoph J et al. 2015. A scoping review of cloud computing in healthcare. BMC Med. Inform. Decis. Mak. 15:17
    [Google Scholar]
  49. 49. 
    Habermann M, Gouveia N 2014. Socioeconomic position and low birth weight among mothers exposed to traffic-related air pollution. PLOS ONE 9:e113900
    [Google Scholar]
  50. 50. 
    Hackstadt AJ, Matsui EC, Williams DL, Diette GB, Breysse PN et al. 2014. Inference for environmental intervention studies using principal stratification. Stat. Med. 33:4919–33
    [Google Scholar]
  51. 51. 
    Hansen BB, Klopfer SO 2006. Optimal full matching and related designs via network flows. J. Comput. Graph. Stat. 15:609–27
    [Google Scholar]
  52. 52. 
    Hernberg S, Tolonen M, Nurminen M 1976. Eight-year follow-up of viscose rayon workers exposed to carbon disulfide. Scand. J. Work Environ. Health 2:27–30
    [Google Scholar]
  53. 53. 
    Hertz-Picciotto I, Schmidt RJ, Krakowiak P 2018. Understanding environmental contributions to autism: causal concepts and the state of science. Autism Res 11:554–86
    [Google Scholar]
  54. 54. 
    Hill AB 1965. The environment and disease: association or causation?. Proc. R. Soc. Med. 58:295–300
    [Google Scholar]
  55. 55. 
    Holland PW 1986. Statistics and causal inference. J. Am. Stat. Assoc. 81:945–60
    [Google Scholar]
  56. 56. 
    Hüls A, Vierkötter A, Sugiri D, Abramson MJ, Ranft U et al. 2018. The role of air pollution and lung function in cognitive impairment. Eur. Respir. J. 51:1701963
    [Google Scholar]
  57. 57. 
    Imbens GW, Rubin DB 2015. Causal Inference for Statistics, Social, and Biomedical Sciences: An Introduction Cambridge, UK: Cambridge Univ. Press
  58. 58. 
    Janes H, Dominici F, Zeger SL 2007. Trends in air pollution and mortality: an approach to the assessment of unmeasured confounding. Epidemiology 18:416–23
    [Google Scholar]
  59. 59. 
    Jarjour S, Jerrett M, Westerdahl D, de Nazelle A, Hanning C et al. 2013. Cyclist route choice, traffic-related air pollution, and lung function: a scripted exposure study. Environ. Health 12:14
    [Google Scholar]
  60. 60. 
    Jiang L, Bai L 2018. Spatio-temporal characteristics of urban air pollutions and their causal relationships: evidence from Beijing and its neighboring cities. Sci. Rep. 8:1279
    [Google Scholar]
  61. 61. 
    Knol AB, de Hartog JJ, Boogaard H, Slottje P, van der Sluijs JP et al. 2009. Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways. Part Fibre Toxicol 6:19
    [Google Scholar]
  62. 62. 
    Künzli N, Braun-Fahrländer C, Rapp R, Ackermann-Liebich U 1997. [Air pollution and health—causal criteria in environmental epidemiology]. Schweiz. Med. Wochenschr. 127:331334–44 (in German)
    [Google Scholar]
  63. 63. 
    LaLonde RJ 1986. Evaluating the econometric evaluations of training programs with experimental data. Am. Econ. Rev. 76:604–20
    [Google Scholar]
  64. 64. 
    Le Tertre A, Quénel P, Eilstein D, Medina S, Prouvost H et al. 2002. Short-term effects of air pollution on mortality in nine French cities: a quantitative summary. Arch. Environ. Health 57:311–19
    [Google Scholar]
  65. 65. 
    Leal C, Bean K, Thomas F, Chaix B 2012. Multicollinearity in associations between multiple environmental features and body weight and abdominal fat: using matching techniques to assess whether the associations are separable. Am. J. Epidemiol. 175:1152–62
    [Google Scholar]
  66. 66. 
    Lewis C, Hoggatt KJ, Ritz B 2011. The impact of different causal models on estimated effects of disinfection by-products on preterm birth. Environ. Res. 111:371–76
    [Google Scholar]
  67. 67. 
    Lu JG, Lee JJ, Gino F, Galinsky AD 2018. Polluted morality: Air pollution predicts criminal activity and unethical behavior. Psychol. Sci. 29:340–55
    [Google Scholar]
  68. 68. 
    Makar M, Antonelli J, Di Q, Cutler D, Schwartz J, Dominici F 2017. Estimating the causal effect of low levels of fine particulate matter on hospitalization. Epidemiology 28:627–34
    [Google Scholar]
  69. 69. 
    Marcus AH, Kegler SR 2001. Confounding in air pollution epidemiology: When does two-stage regression identify the problem?. Environ. Health Perspect. 109:1193–96
    [Google Scholar]
  70. 70. 
    Mauderly JL, Kracko D, Brower J, Doyle-Eisele M, McDonald JD et al. 2014. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhal. Toxicol. 26:691–96
    [Google Scholar]
  71. 71. 
    Mauderly JL, Seilkop SK 2014. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer biological responses in rodents. Inhal. Toxicol. 26:668–90
    [Google Scholar]
  72. 72. 
    Moore KL, Neugebauer R, van der Laan MJ, Tager IB 2012. Causal inference in epidemiological studies with strong confounding. Stat. Med. 31:1380–404
    [Google Scholar]
  73. 73. 
    Morgan KL, Rubin DB 2012. Rerandomization to improve covariate balance in experiments. Ann. Statist. 40:1263–82
    [Google Scholar]
  74. 74. 
    Oulhote Y, Bind M-A, Coull B, Patel CJ, Grandjean P 2017. Combining ensemble learning techniques and g-computation to investigate chemical mixtures in environmental epidemiology studies. bioRxiv 147413. https://doi.org/10.1101/147413
    [Crossref]
  75. 75. 
    Owens EO, Patel MM, Kirrane E, Long TC, Brown J et al. 2017. Framework for assessing causality of air pollution-related health effects for reviews of the National Ambient Air Quality Standards. Regul. Toxicol. Pharmacol. 88:332–37
    [Google Scholar]
  76. 76. 
    Padula AM, Mortimer K, Hubbard A, Lurmann F, Jerrett M, Tager IB 2012. Exposure to traffic-related air pollution during pregnancy and term low birth weight: estimation of causal associations in a semiparametric model. Am. J. Epidemiol. 176:815–24
    [Google Scholar]
  77. 77. 
    Perret JL, Bowatte G, Lodge CJ, Knibbs LD, Gurrin LC et al. 2017. The dose-response association between nitrogen dioxide exposure and serum interleukin-6 concentrations. Int. J. Mol. Sci. 18:E1015
    [Google Scholar]
  78. 78. 
    Peyre G, Cuturi M 2018. Computational optimal transport. arXiv 1803.00567
  79. 79. 
    Picciotto S, Eisen EA, Chevrier J 2014. 0351 g-estimation: Why does it work and what does it offer?. Occup. Environ. Med. 71:A120–21
    [Google Scholar]
  80. 80. 
    Pope CA 3rd, Burnett RT 2007. Confounding in air pollution epidemiology: the broader context. Epidemiology 18:424–26
    [Google Scholar]
  81. 81. 
    Power MC, Adar SD, Yanosky JD, Weuve J 2016. Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: a systematic review of epidemiologic research. Neurotoxicology 56:235–53
    [Google Scholar]
  82. 82. 
    Prandota J, Stolarczyk J 2002. Autoimmune hepatitis associated with the odour of fish food proteins: a causal relationship or just a mere association?. Allergol. Immunopathol. 30:331–37
    [Google Scholar]
  83. 83. 
    Relton CL, Davey Smith G 2015. Mendelian randomization: applications and limitations in epigenetic studies. Epigenomics 7:1239–43
    [Google Scholar]
  84. 84. 
    Robins J 1986. A new approach to causal inference in mortality studies with a sustained exposure period—application to control of the healthy worker survivor effect. Math. Model. 7:1393–512
    [Google Scholar]
  85. 85. 
    Rosenbaum PR 2012. Optimal matching of an optimally chosen subset in observational studies. J. Comput. Graph. Stat. 21:57–71
    [Google Scholar]
  86. 86. 
    Rubin DB 1974. Estimating causal effects of treatments in randomized and nonrandomized studies. J. Educ. Psychol. 66:688–701
    [Google Scholar]
  87. 87. 
    Rubin DB 2006. William G. Cochran's Contributions to the Design, Analysis, and Evaluation of Observational Studies. Matched Sampling for Causal Effects7–29 Cambridge, UK: Cambridge Univ. Press
    [Google Scholar]
  88. 88. 
    Rubin DB 2007. The design versus the analysis of observational studies for causal effects: parallels with the design of randomized trials. Stat. Med. 26:20–36
    [Google Scholar]
  89. 89. 
    Saber AT, Jacobsen NR, Jackson P, Poulsen SS, Kyjovska ZO et al. 2014. Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6:517–31
    [Google Scholar]
  90. 90. 
    Samet JM, Zeger SL, Dominici F, Curriero F, Coursac I et al. 2000. The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. Res. Rep. Health Eff. Inst. 94:5–70
    [Google Scholar]
  91. 91. 
    Schwartz J 1994. Air pollution and hospital admissions for the elderly in Detroit, Michigan. Am. J. Respir. Crit. Care Med. 150:648–55
    [Google Scholar]
  92. 92. 
    Schwartz J 1994. What are people dying of on high air pollution days?. Environ. Res. 64:26–35
    [Google Scholar]
  93. 93. 
    Schwartz J 1999. Air pollution and hospital admissions for heart disease in eight U.S. counties. Epidemiology 10:17–22
    [Google Scholar]
  94. 94. 
    Schwartz J, Austin E, Bind MA, Zanobetti A, Koutrakis P 2015. Estimating causal associations of fine particles with daily deaths in Boston. Am. J. Epidemiol. 182:644–50
    [Google Scholar]
  95. 95. 
    Schwartz J, Bind MA, Koutrakis P 2017. Estimating causal effects of local air pollution on daily deaths: effect of low levels. Environ. Health Perspect. 125:23–29
    [Google Scholar]
  96. 96. 
    Selvin S, Merrill D, Wong L, Sacks ST 1984. Ecologic regression analysis and the study of the influence of air quality on mortality. Environ. Health Perspect. 54:333–40
    [Google Scholar]
  97. 97. 
    Sheldon TL, Sankaran C 2017. The impact of Indonesian forest fires on Singaporean pollution and health. Am. Econ. Rev. 107:526–29
    [Google Scholar]
  98. 98. 
    Sinharay R, Gong J, Barratt B, Ohman-Strickland P, Ernst S et al. 2018. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. Lancet 391:339–49
    [Google Scholar]
  99. 99. 
    Snow J 1856. On the mode of communication of cholera. Edinb. Med. J. 1:668–70
    [Google Scholar]
  100. 100. 
    Sommer A, Lee M, Bind M-A 2018. Comparing apples to apples: an environmental criminology analysis of the effects of heat and rain on violent crimes in Boston. Palgrave Commun 4:138
    [Google Scholar]
  101. 101. 
    Stuart EA 2010. Matching methods for causal inference: a review and a look forward. Stat. Sci. 25:1–21
    [Google Scholar]
  102. 102. 
    Thistlethwaite DL, Campbell DT 1960. Regression-discontinuity analysis: an alternative to the ex post facto experiment. J. Educ. Psychol. 2:119–28
    [Google Scholar]
  103. 103. 
    Tolonen M, Hernberg S, Nurminen M, Tiitola K 1975. A follow-up study of coronary heart disease in viscose rayon workers exposed to carbon disulphide. Br. J. Ind. Med. 32:1–10
    [Google Scholar]
  104. 104. 
    Tommasi S, Zheng A, Yoon J-I, Li AX, Wu X, Besaratinia A 2012. Whole DNA methylome profiling in mice exposed to secondhand smoke. Epigenetics 7:1302–14
    [Google Scholar]
  105. 105. 
    Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R 2013. Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry 70:71–77
    [Google Scholar]
  106. 106. 
    Wang Y, Kloog I, Coull BA, Kosheleva A, Zanobetti A, Schwartz JD 2016. Estimating causal effects of long-term PM2.5 exposure on mortality in New Jersey. Environ. Health Perspect. 124:1182–88
    [Google Scholar]
  107. 107. 
    Weisskopf MG, Kioumourtzoglou MA, Roberts AL 2015. Air pollution and autism spectrum disorders: causal or confounded?. Curr. Environ. Health Rep. 2:430–39
    [Google Scholar]
  108. 108. 
    Wong C-M, Atkinson RW, Anderson HR, Hedley AJ, Ma S et al. 2002. A tale of two cities: effects of air pollution on hospital admissions in Hong Kong and London compared. Environ. Health Perspect. 110:67–77
    [Google Scholar]
  109. 109. 
    Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL 2009. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD 6:86–94
    [Google Scholar]
  110. 110. 
    Yang C, Zhao W, Deng K, Zhou V, Zhou X, Hou Y 2017. The association between air pollutants and autism spectrum disorders. Environ. Sci. Pollut. Res. Int. 24:15949–58
    [Google Scholar]
  111. 111. 
    Yang S, Tan Y, Mei H, Wang F, Li N et al. 2018. Ambient air pollution the risk of stillbirth: a prospective birth cohort study in Wuhan, China. Int. J. Hyg. Environ. Health 221:502–9
    [Google Scholar]
  112. 112. 
    Zhong J, Trevisi L, Urch B, Lin X, Speck M et al. 2017. B-vitamin supplementation mitigates effects of fine particles on cardiac autonomic dysfunction and inflammation: a pilot human intervention trial. Sci. Rep. 7:45322
    [Google Scholar]
  113. 113. 
    Zigler CM, Choirat C, Dominici F 2018. Impact of National Ambient Air Quality Standards nonattainment designations on particulate pollution and health. Epidemiology 29:165–74
    [Google Scholar]
  114. 114. 
    Zigler CM, Dominici F 2014. Point: clarifying policy evidence with potential-outcomes thinking—beyond exposure-response estimation in air pollution epidemiology. Am. J. Epidemiol. 180:1133–40
    [Google Scholar]
  115. 115. 
    Zigler CM, Dominici F, Wang Y 2012. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 13:289–302
    [Google Scholar]
  116. 116. 
    Zigler CM, Kim C, Choirat C, Hansen JB, Wang Y et al. 2016. Causal inference methods for estimating long-term health effects of air quality regulations Res. Rep. 187 Health Eff. Inst https://www.healtheffects.org/system/files/ZiglerRR187.pdf
  117. 117. 
    Zubizarreta JR, Kilcioglu C, Vielma JP 2018. designmatch: matched samples that are balanced and representative by design. R Package Version 0.3.1. https://cran.r-project.org/web/packages/designmatch/index.html
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