B CELL IMMUNOBIOLOGY IN DISEASE: Evolving Concepts from the Clinic

Annual Review of Immunology

Vol. 24:467-496 (Volume publication date 23 April 2006)
First published online as a Review in Advance on January 16, 2006


AbstractThe pathogenic roles of B cells in autoimmune diseases occur through several mechanistic pathways that include autoantibodies, immune complexes, dendritic and T cell activation, cytokine synthesis, chemokine-mediated functions, and ectopic neolymphogenesis. Each of these pathways participate to different degrees in autoimmune diseases. The use of B cell–targeted and B cell subset–targeted therapies in humans is illuminating the mechanisms at work in a variety of human autoimmune diseases. In this review, we highlight some of these recent findings that provide insights into both murine models of autoimmunity and human autoimmune diseases.