1932

Abstract

Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e.g., nanoparticles to implants); and exhibit tuned, targeted, and/or responsive drug release behavior. The functional behavior of LbL films can be related to their physicochemical properties. In this review, we highlight recent advances in the development of LbL-engineered biomaterials for drug delivery, demonstrating their potential in the fields of cancer therapy, microbial infection prevention and treatment, and directing cellular responses. We discuss the various advantages of LbL biomaterial design for a given application as demonstrated through in vitro and in vivo studies.

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2020-06-04
2024-03-29
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Literature Cited

  1. 1. 
    Iler R 1966. Multilayers of colloidal particles. J. Colloid Interface Sci. 21:569–94
    [Google Scholar]
  2. 2. 
    Decher G, Hong JD 1991. Buildup of ultrathin multilayer films by a self-assembly process. I: Consecutive adsorption of anionic and cationic bipolar amphiphiles on charged surfaces. Makromol. Chem. Macromol. Symp. 46:321–27
    [Google Scholar]
  3. 3. 
    Saurer EM, Jewell CM, Roenneburg DA, Bechler SL, Torrealba JR et al. 2013. Polyelectrolyte multilayers promote stent-mediated delivery of DNA to vascular tissue. Biomacromolecules 14:1696–704
    [Google Scholar]
  4. 4. 
    Shukla A, Fang JC, Puranam S, Hammond PT 2012. Release of vancomycin from multilayer coated absorbent gelatin sponges. J. Control. Release 157:64–71
    [Google Scholar]
  5. 5. 
    Krogman KC, Cohen RE, Hammond PT, Rubner MF, Wang BN 2013. Industrial-scale spray layer-by-layer assembly for production of biomimetic photonic systems. Bioinspir. Biomim. 8:045005
    [Google Scholar]
  6. 6. 
    Shukla A, Almeida B 2014. Advances in cellular and tissue engineering using layer-by-layer assembly. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6:411–21
    [Google Scholar]
  7. 7. 
    Liu T, Wang Y, Zhong W, Li B, Mequanint K et al. 2019. Biomedical applications of layer-by-layer self-assembly for cell encapsulation: current status and future perspectives. Adv. Healthc. Mater. 8:1800939
    [Google Scholar]
  8. 8. 
    Fukuda Y, Akagi T, Asaoka T, Eguchi H, Sasaki K et al. 2018. Layer-by-layer cell coating technique using extracellular matrix facilitates rapid fabrication and function of pancreatic β-cell spheroids. Biomaterials 160:82–91
    [Google Scholar]
  9. 9. 
    Cai X, Gao X, Wang L, Wu Q, Lin X 2013. A layer-by-layer assembled and carbon nanotubes/gold nanoparticles–based bienzyme biosensor for cholesterol detection. Sens. Actuators B 181:575–83
    [Google Scholar]
  10. 10. 
    Barsan MM, David M, Florescu M, Tugulea L, Brett CM 2014. A new self-assembled layer-by-layer glucose biosensor based on chitosan biopolymer entrapped enzyme with nitrogen doped graphene. Bioelectrochemistry 99:46–52
    [Google Scholar]
  11. 11. 
    Séon L, Lavalle P, Schaaf P, Boulmedais F 2015. Polyelectrolyte multilayers: a versatile tool for preparing antimicrobial coatings. Langmuir 31:12856–72
    [Google Scholar]
  12. 12. 
    Tang T, Weng T, Jia H, Luo S, Xu Y et al. 2019. Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications. Biomater. Sci. 7:715–32
    [Google Scholar]
  13. 13. 
    Costa RR, Alatorre-Meda M, Mano JF 2015. Drug nano-reservoirs synthesized using layer-by-layer technologies. Biotechnol. Adv. 33:1310–26
    [Google Scholar]
  14. 14. 
    Shukla A, Fang JC, Puranam S, Jensen FR, Hammond PT 2012. Hemostatic multilayer coatings. Adv. Mater. 24:492–96
    [Google Scholar]
  15. 15. 
    Pérez-Anes A, Gargouri M, Laure W, Van Den Berghe H, Courcot E et al. 2015. Bioinspired titanium drug eluting platforms based on a poly-β-cyclodextrin-chitosan layer-by-layer self-assembly targeting infections. ACS Appl. Mater. Interfaces 7:12882–93
    [Google Scholar]
  16. 16. 
    Turvey ME, Uppu DS, Sharif ARM, Bidet K, Alonso S et al. 2019. Microneedle-based intradermal delivery of stabilized dengue virus. Bioeng. Transl. Med. 4:e10127
    [Google Scholar]
  17. 17. 
    Anselmo AC, Gilbert JB, Kumar S, Gupta V, Cohen RE et al. 2015. Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation. J. Control. Release 199:29–36
    [Google Scholar]
  18. 18. 
    Luo GF, Xu XD, Zhang J, Yang J, Gong YH et al. 2012. Encapsulation of an adamantane-doxorubicin prodrug in pH-responsive polysaccharide capsules for controlled release. ACS Appl. Mater. Interfaces 4:5317–24
    [Google Scholar]
  19. 19. 
    Chen WH, Luo GF, Qiu WX, Lei Q, Liu LH et al. 2017. Mesoporous silica–based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy. Biomaterials 117:54–65
    [Google Scholar]
  20. 20. 
    Borges J, Mano JF 2014. Molecular interactions driving the layer-by-layer assembly of multilayers. Chem. Rev. 114:8883–942
    [Google Scholar]
  21. 21. 
    Izquierdo A, Ono SS, Voegel JC, Schaaf P, Decher G 2005. Dipping versus spraying: exploring the deposition conditions for speeding up layer-by-layer assembly. Langmuir 21:7558–67
    [Google Scholar]
  22. 22. 
    Kharlampieva E, Kozlovskaya V, Chan J, Ankner JF, Tsukruk VV 2009. Spin-assisted layer-by-layer assembly: variation of stratification as studied with neutron reflectivity. Langmuir 25:14017–24
    [Google Scholar]
  23. 23. 
    Hong X, Li J, Wang M, Xu J, Guo W et al. 2004. Fabrication of magnetic luminescent nanocomposites by a layer-by-layer self-assembly approach. Chem. Mater. 16:4022–27
    [Google Scholar]
  24. 24. 
    Kantak C, Beyer S, Yobas L, Bansal T, Trau D 2011. A ‘microfluidic pinball’ for on-chip generation of layer-by-layer polyelectrolyte microcapsules. Lab Chip 11:1030–35
    [Google Scholar]
  25. 25. 
    DeRocher JP, Mao P, Han J, Rubner MF, Cohen RE 2010. Layer-by-layer assembly of polyelectrolytes in nanofluidic devices. Macromolecules 43:2430–37
    [Google Scholar]
  26. 26. 
    Deleted in proof
  27. 27. 
    Andres CM, Kotov NA 2010. Inkjet deposition of layer-by-layer assembled films. J. Am. Chem. Soc. 132:14496–502
    [Google Scholar]
  28. 28. 
    Sung YY, Rubner MF 2002. Micropatterning of polymer thin films with pH-sensitive and cross-linkable hydrogen-bonded polyelectrolyte multilayers. J. Am. Chem. Soc. 124:2100–1
    [Google Scholar]
  29. 29. 
    Clark SL, Montague M, Hammond PT 1997. Selective deposition in multilayer assembly: SAMs as molecular templates. Supramol. Sci. 4:141–46
    [Google Scholar]
  30. 30. 
    Richardson JJ, Björnmalm M, Caruso F 2015. Technology-driven layer-by-layer assembly of nanofilms. Science 348:aaa2491
    [Google Scholar]
  31. 31. 
    Richardson JJ, Cui J, Björnmalm M, Braunger JA, Ejima H, Caruso F 2016. Innovation in layer-by-layer assembly. Chem. Rev. 116:14828–67
    [Google Scholar]
  32. 32. 
    Salomäki M, Vinokurov IA, Kankare J 2005. Effect of temperature on the buildup of polyelectrolyte multilayers. Langmuir 21:11232–40
    [Google Scholar]
  33. 33. 
    Dubas ST, Schlenoff JB 1999. Factors controlling the growth of polyelectrolyte multilayers. Macromolecules 32:8153–60
    [Google Scholar]
  34. 34. 
    Dubas ST, Schlenoff JB 2001. Polyelectrolyte multilayers containing a weak polyacid: construction and deconstruction. Macromolecules 34:3736–40
    [Google Scholar]
  35. 35. 
    Schönhoff M, Bieker P 2010. Linear and exponential growth regimes of multilayers of weak polyelectrolytes in dependence on pH. Macromolecules 43:5052–59
    [Google Scholar]
  36. 36. 
    Sui Z, Salloum D, Schlenoff JB 2003. Effect of molecular weight on the construction of polyelectrolyte multilayers: stripping versus sticking. Langmuir 19:2491–95
    [Google Scholar]
  37. 37. 
    Porcel C, Lavalle P, Decher G, Senger B, Voegel JC, Schaaf P 2007. Influence of the polyelectrolyte molecular weight on exponentially growing multilayer films in the linear regime. Langmuir 23:1898–904
    [Google Scholar]
  38. 38. 
    Selin V, Ankner JF, Sukhishvili SA 2017. Nonlinear layer-by-layer films: effects of chain diffusivity on film structure and swelling. Macromolecules 50:6192–201
    [Google Scholar]
  39. 39. 
    Fu J, Schlenoff JB 2016. Driving forces for oppositely charged polyion association in aqueous solutions: enthalpic, entropic, but not electrostatic. J. Am. Chem. Soc. 138:980–90
    [Google Scholar]
  40. 40. 
    Ghostine RA, Markarian MZ, Schlenoff JB 2013. Asymmetric growth in polyelectrolyte multilayers. J. Am. Chem. Soc. 135:7636–46
    [Google Scholar]
  41. 41. 
    Fares HM, Schlenoff JB 2017. Diffusion of sites versus polymers in polyelectrolyte complexes and multilayers. J. Am. Chem. Soc. 139:14656–67
    [Google Scholar]
  42. 42. 
    Michaels AS, Miekka RG 1961. Polycation–polyanion complexes: preparation and properties of poly-(vinylbenzyltrimethylammonium) poly-(styrenesulfonate). J. Phys. Chem. 65:1765–73
    [Google Scholar]
  43. 43. 
    Ladam G, Schaad P, Voegel JC, Schaaf P, Decher G, Cuisinier F 2000. In situ determination of the structural properties of initially deposited polyelectrolyte multilayers. Langmuir 16:1249–55
    [Google Scholar]
  44. 44. 
    Clark SL, Montague MF, Hammond PT 1997. Ionic effects of sodium chloride on the templated deposition of polyelectrolytes using layer-by-layer ionic assembly. Macromolecules 30:7237–44
    [Google Scholar]
  45. 45. 
    Castleberry SA, Almquist BD, Li W, Reis T, Chow J et al. 2016. Self-assembled wound dressings silence MMP-9 and improve diabetic wound healing in vivo. Adv. Mater. 28:1809–17
    [Google Scholar]
  46. 46. 
    Truong-Phuoc L, Christoforidis KC, Vigneron F, Papaefthimiou V, Decher G et al. 2016. Layer-by-layer photocatalytic assembly for solar light–activated self-decontaminating textiles. ACS Appl. Mater. Interfaces 8:34438–45
    [Google Scholar]
  47. 47. 
    Jia Z, Xiu P, Roohani-Esfahani SI, Zreiqat H, Xiong P et al. 2019. Triple-bioinspired burying/crosslinking interfacial coassembly strategy for layer-by-layer construction of robust functional bioceramic self-coatings for osteointegration applications. ACS Appl. Mater. Interfaces 11:4447–69
    [Google Scholar]
  48. 48. 
    Correa S, Boehnke N, Deiss-Yehiely E, Hammond PT 2019. Solution conditions tune and optimize loading of therapeutic polyelectrolytes into layer-by-layer functionalized liposomes. ACS Nano 13:5623–34
    [Google Scholar]
  49. 49. 
    Caruso F 2001. Nanoengineering of particle surfaces. Adv. Mater. 13:11–22
    [Google Scholar]
  50. 50. 
    Schneider G, Decher G 2004. From functional core/shell nanoparticles prepared via layer-by-layer deposition to empty nanospheres. Nano Lett. 4:1833–39
    [Google Scholar]
  51. 51. 
    Pavlukhina S, Zhuk I, Mentbayeva A, Rautenberg E, Chang W et al. 2014. Small-molecule-hosting nanocomposite films with multiple bacteria-triggered responses. NPG Asia Mater. 6:e121
    [Google Scholar]
  52. 52. 
    Hsu BB, Park MH, Hagerman SR, Hammond PT 2014. Multimonth controlled small molecule release from biodegradable thin films. PNAS 111:12175–80
    [Google Scholar]
  53. 53. 
    Zhuk I, Jariwala F, Attygalle AB, Wu Y, Libera MR, Sukhishvili SA 2014. Self-defensive layer-by-layer films with bacteria-triggered antibiotic release. ACS Nano 8:7733–45
    [Google Scholar]
  54. 54. 
    Albright V, Zhuk I, Wang Y, Selin V, van de Belt-Gritter B et al. 2017. Self-defensive antibiotic-loaded layer-by-layer coatings: imaging of localized bacterial acidification and pH-triggering of antibiotic release. Acta Biomater. 61:66–74
    [Google Scholar]
  55. 55. 
    Zhang J, Ma PX 2013. Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective. Adv. Drug Deliv. Rev. 65:1215–33
    [Google Scholar]
  56. 56. 
    Junthip J, Tabary N, Chai F, Leclercq L, Maton M et al. 2016. Layer-by-layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery. J. Biomed. Mater. Res. A 104:1408–24
    [Google Scholar]
  57. 57. 
    Jing J, Szarpak-Jankowska A, Guillot R, Pignot-Paintrand I, Picart C, Auzély-Velty R 2013. Cyclodextrin/paclitaxel complex in biodegradable capsules for breast cancer treatment. Chem. Mater. 25:3867–73
    [Google Scholar]
  58. 58. 
    Huang T, Luan X, Xia Q, Pan S, An Q et al. 2018. Molecularly selective regulation of delivery fluxes by employing supramolecular interactions in layer-by-layer films. Chem. Asian J. 13:1067–73
    [Google Scholar]
  59. 59. 
    Wang B, Shi S, Nan K, Xu Q, Ye Z et al. 2017. A self-defensive antibacterial coating acting through the bacteria-triggered release of a hydrophobic antibiotic from layer-by-layer films. J. Mater. Chem. B 5:1498–506
    [Google Scholar]
  60. 60. 
    Zhang H, Wang D, Zuo X, Gao C 2019. UV-responsive multilayers with multiple functions for biofilm destruction and tissue regeneration. ACS Appl. Mater. Interfaces 11:17283–93
    [Google Scholar]
  61. 61. 
    Zhu Z, Gao N, Wang H, Sukhishvili SA 2013. Temperature-triggered on-demand drug release enabled by hydrogen-bonded multilayers of block copolymer micelles. J. Control. Release 171:73–80
    [Google Scholar]
  62. 62. 
    Min J, Choi KY, Dreaden EC, Padera RF, Braatz RD et al. 2016. Designer dual therapy nanolayered implant coatings eradicate biofilms and accelerate bone tissue repair. ACS Nano 10:4441–50
    [Google Scholar]
  63. 63. 
    Shah NJ, Hyder MN, Moskowitz JS, Quadir MA, Morton SW et al. 2013. Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings. Sci. Transl. Med. 5:191ra83
    [Google Scholar]
  64. 64. 
    Lin M, Gao Y, Diefenbach TJ, Shen JK, Hornicek FJ et al. 2017. Facial layer-by-layer engineering of upconversion nanoparticles for gene delivery: near-infrared-initiated fluorescence resonance energy transfer tracking and overcoming drug resistance in ovarian cancer. ACS Appl. Mater. Interfaces 9:7941–49
    [Google Scholar]
  65. 65. 
    Kim JO, Ramasamy T, Tran TH, Choi JY, Cho HJ et al. 2014. Layer-by-layer coated lipid–polymer hybrid nanoparticles designed for use in anticancer drug delivery. Carbohydr. Polym. 102:653–61
    [Google Scholar]
  66. 66. 
    Feng W, Nie W, He C, Zhou X, Chen L et al. 2014. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers. ACS Appl. Mater. Interfaces 6:8447–60
    [Google Scholar]
  67. 67. 
    Dreaden EC, Morton SW, Shopsowitz KE, Choi JH, Deng ZJ et al. 2014. Bimodal tumor-targeting from microenvironment responsive hyaluronan layer-by-layer (LbL) nanoparticles. ACS Nano 8:8374–82
    [Google Scholar]
  68. 68. 
    Li J, Qu X, Payne GF, Zhang C, Zhang Y et al. 2015. Biospecific self-assembly of a nanoparticle coating for targeted and stimuli-responsive drug delivery. Adv. Funct. Mater. 25:1404–17
    [Google Scholar]
  69. 69. 
    Deng ZJ, Morton SW, Ben-Akiva E, Dreaden EC, Shopsowitz KE, Hammond PT 2013. Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment. ACS Nano 7:9571–84
    [Google Scholar]
  70. 70. 
    Shukla A, Puranam S, Hammond PT 2012. Vancomycin storage stability in multilayer thin film coatings for on-demand care. J. Biomater. Sci. Polym. Ed. 23:1895–902
    [Google Scholar]
  71. 71. 
    Demuth PC, Min Y, Huang B, Kramer JA, Miller AD et al. 2013. Polymer multilayer tattooing for enhanced DNA vaccination. Nat. Mater. 12:367–76
    [Google Scholar]
  72. 72. 
    Wang X, Wu J, Li P, Wang L, Zhou J et al. 2018. Microenvironment-responsive magnetic nanocomposites based on silver nanoparticles/gentamicin for enhanced biofilm disruption by magnetic field. ACS Appl. Mater. Interfaces 10:34905–15
    [Google Scholar]
  73. 73. 
    Tao B, Deng Y, Song L, Ma W, Qian Y et al. 2019. BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement. Colloids Surf. B 177:242–52
    [Google Scholar]
  74. 74. 
    Choi KY, Correa S, Min J, Li J, Roy S et al. 2019. Binary targeting of siRNA to hematologic cancer cells in vivo using layer-by-layer nanoparticles. Adv. Funct. Mater. 29:1900018
    [Google Scholar]
  75. 75. 
    Correa S, Dreaden EC, Gu L, Hammond PT 2016. Engineering nanolayered particles for modular drug delivery. J. Control. Release 240:364–86
    [Google Scholar]
  76. 76. 
    Jeong H, Hwang J, Lee H, Hammond PT, Choi J, Hong J 2017. In vitro blood cell viability profiling of polymers used in molecular assembly. Sci. Rep. 7:9481
    [Google Scholar]
  77. 77. 
    Selin V, Ankner J, Sukhishvili S 2018. Ionically paired layer-by-layer hydrogels: water and polyelectrolyte uptake controlled by deposition time. Gels 4:7
    [Google Scholar]
  78. 78. 
    Guo X, Carter MCD, Appadoo V, Lynn DM 2019. Tunable and selective degradation of amine-reactive multilayers in acidic media. Biomacromolecules 20:3464–74
    [Google Scholar]
  79. 79. 
    Wood KC, Chuang HF, Batten RD, Lynn DM, Hammond PT 2006. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. PNAS 103:10207–12
    [Google Scholar]
  80. 80. 
    Min J, Braatz RD, Hammond PT 2014. Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier. Biomaterials 35:2507–17
    [Google Scholar]
  81. 81. 
    Delcea M, Möhwald H, Skirtach AG 2011. Stimuli-responsive LbL capsules and nanoshells for drug delivery. Adv. Drug Deliv. Rev. 63:730–47
    [Google Scholar]
  82. 82. 
    Nam K, Kim T, Kim YM, Yang K, Choe D et al. 2019. Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery. Chem. Commun. 55:4905–8
    [Google Scholar]
  83. 83. 
    Morton SW, Shah NJ, Quadir MA, Deng ZJ, Poon Z, Hammond PT 2014. Osteotropic therapy via targeted layer-by-layer nanoparticles. Adv. Healthc. Mater. 3:867–75
    [Google Scholar]
  84. 84. 
    Bonner DK, Leung C, Chen-Liang J, Chingozha L, Langer R, Hammond PT 2011. Intracellular trafficking of polyamidoamine–poly(ethylene glycol) block copolymers in DNA delivery. Bioconjug. Chem. 22:1519–25
    [Google Scholar]
  85. 85. 
    Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ 2007. Cancer statistics, 2007. CA Cancer J. Clin. 57:43–66
    [Google Scholar]
  86. 86. 
    Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML 2011. Projections of the cost of cancer care in the United States: 2010–2020. J. Natl. Cancer Inst. 103:117–28
    [Google Scholar]
  87. 87. 
    Cavaletti G, Marmiroli P 2015. Chemotherapy-induced peripheral neurotoxicity. Curr. Opin. Neurol. 28:500–7
    [Google Scholar]
  88. 88. 
    Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY et al. 2015. Tumor-targeted synergistic blockade of MAPK and PI3K from a layer-by-layer nanoparticle. Clin. Cancer Res. 21:4410–19
    [Google Scholar]
  89. 89. 
    Liu XQ, Picart C 2016. Layer-by-layer assemblies for cancer treatment and diagnosis. Adv. Mater. 28:1295–301
    [Google Scholar]
  90. 90. 
    Yan Y, Zuo X, Wei D 2015. Emerging role of CD44 in cancer stem cells: a promising biomarker and therapeutic target. Stem Cells Transl. Med. 4:1033–43
    [Google Scholar]
  91. 91. 
    Mattheolabakis G, Milane L, Singh A, Amiji MM 2015. Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine. J. Drug Target. 23:605–18
    [Google Scholar]
  92. 92. 
    Smith MR 2003. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene 22:7359–68
    [Google Scholar]
  93. 93. 
    Li X, Kim J, Yoon J, Chen X 2017. Cancer-associated, stimuli-driven, turn on theranostics for multimodality imaging and therapy. Adv. Mater. 29:1606857
    [Google Scholar]
  94. 94. 
    Wu Z, Lin X, Zou X, Sun J, He Q 2015. Biodegradable protein-based rockets for drug transportation and light-triggered release. ACS Appl. Mater. Interfaces 7:250–55
    [Google Scholar]
  95. 95. 
    Katagiri K, Nakamura M, Koumoto K 2010. Magnetoresponsive smart capsules formed with polyelectrolytes, lipid bilayers and magnetic nanoparticles. ACS Appl. Mater. Interfaces 2:768–73
    [Google Scholar]
  96. 96. 
    Jain RK, Stylianopoulos T 2010. Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol. 7:653–64
    [Google Scholar]
  97. 97. 
    Such GK, Yan Y, Johnston APR, Gunawan ST, Caruso F 2015. Interfacing materials science and biology for drug carrier design. Adv. Mater. 27:2278–97
    [Google Scholar]
  98. 98. 
    Li QL, Sun Y, Sun YL, Wen J, Zhou Y et al. 2014. Mesoporous silica nanoparticles coated by layer-by-layer self-assembly using cucurbit[7]uril for in vitro and in vivo anticancer drug release. Chem. Mater. 26:6418–31
    [Google Scholar]
  99. 99. 
    Gu L, Deng ZJ, Roy S, Hammond PT 2017. A combination RNAi–chemotherapy layer-by-layer nanoparticle for systemic targeting of KRAS/P53 with cisplatin to treat nonsmall cell lung cancer. Clin. Cancer Res. 23:7312–23
    [Google Scholar]
  100. 100. 
    Klevens RM, Edwards JR, Richards CL, Horan TC, Gaynes RP et al. 2007. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 122:160–66
    [Google Scholar]
  101. 101. 
    Bartlett JG 2004. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin–sulbactam/amoxicillin–clavulanate. Infect. Dis. Clin. Pract. 12:267–68
    [Google Scholar]
  102. 102. 
    Davies D 2003. Understanding biofilm resistance to antibacterial agents. Nat. Rev. Drug Discov. 2:114–22
    [Google Scholar]
  103. 103. 
    Cloutier M, Mantovani D, Rosei F 2015. Antibacterial coatings: challenges, perspectives, and opportunities. Trends Biotechnol. 33:637–52
    [Google Scholar]
  104. 104. 
    Alkekhia D, Shukla A 2019. Influence of poly-l-lysine molecular weight on antibacterial efficacy in polymer multilayer films. J. Biomed. Mater. Res. A 107:1324–39
    [Google Scholar]
  105. 105. 
    United Nations 2019.No time to wait: securing the future from drug-resistant infections Tech. Rep., United Nations, New York
  106. 106. 
    Aslam B, Wang W, Arshad MI, Khurshid M, Muzammil S et al. 2018. Antibiotic resistance: a rundown of a global crisis. Infect. Drug Resist. 11:1645–58
    [Google Scholar]
  107. 107. 
    Li X, Wu B, Chen H, Nan K, Jin Y et al. 2018. Recent developments in smart antibacterial surfaces to inhibit biofilm formation and bacterial infections. J. Mater. Chem. B 6:4274–92
    [Google Scholar]
  108. 108. 
    Laloyaux X, Fautré E, Blin T, Purohit V, Leprince J et al. 2010. Temperature-responsive polymer brushes switching from bactericidal to cell-repellent. Adv. Mater. 22:5024–28
    [Google Scholar]
  109. 109. 
    Smith SM 1991. d-Lactic acid production as a monitor of the effectiveness of antimicrobial agents. Antimicrob. Agents Chemother. 35237–41
  110. 110. 
    Francesko A, Fernandes MM, Ivanova K, Amorim S, Reis RL et al. 2016. Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters. Acta Biomater. 33:203–12
    [Google Scholar]
  111. 111. 
    Menzel EJ, Farr C 1998. Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses. Cancer Lett. 131:3–11
    [Google Scholar]
  112. 112. 
    Ibberson CB, Jones CL, Singh S, Wise MC, Hart ME et al. 2014. Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor. Infect. Immun. 82:4253–64
    [Google Scholar]
  113. 113. 
    Wang B, Liu H, Sun L, Jin Y, Ding X et al. 2018. Construction of high drug loading and enzymatic degradable multilayer films for self-defense drug release and long-term biofilm inhibition. Biomacromolecules 19:85–93
    [Google Scholar]
  114. 114. 
    Wei T, Tang Z, Yu Q, Chen H 2017. Smart antibacterial surfaces with switchable bacteria-killing and bacteria-releasing capabilities. ACS Appl. Mater. Interfaces 9:37511–23
    [Google Scholar]
  115. 115. 
    Xu Q, Li X, Jin Y, Sun L, Ding X et al. 2017. Bacterial self-defense antibiotics release from organic–inorganic hybrid multilayer films for long-term anti-adhesion and biofilm inhibition properties. Nanoscale 9:19245–54
    [Google Scholar]
  116. 116. 
    Pletzer D, Mansour SC, Hancock REW 2018. Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens. PLOS Pathog. 14:e1007084
    [Google Scholar]
  117. 117. 
    Wu Y, Long Y, Li QL, Han S, Ma J et al. 2015. Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient antibacterial applications. ACS Appl. Mater. Interfaces 7:17255–63
    [Google Scholar]
  118. 118. 
    Zhang S, Xing M, Li B 2018. Biomimetic layer-by-layer self-assembly of nanofilms, nanocoatings, and 3D scaffolds for tissue engineering. Int. J. Mol. Sci. 19:e1641
    [Google Scholar]
  119. 119. 
    Zeng J, Matsusaki M 2019. Layer-by-layer assembly of nanofilms to control cell functions. Polym. Chem. 10:2960–74
    [Google Scholar]
  120. 120. 
    Oliveira MB, Hatami J, Mano JF 2016. Coating strategies using layer-by-layer deposition for cell encapsulation. Chem. Asian J. 11:1753–64
    [Google Scholar]
  121. 121. 
    Busscher HJ, van der Mei HC, Subbiahdoss G, Jutte PC, van den Dungen JJ et al. 2012. Biomaterial-associated infection: locating the finish line in the race for the surface. Sci. Transl. Med. 4:153rv10
    [Google Scholar]
  122. 122. 
    Sutrisno L, Hu Y, Shen X, Li M, Luo Z et al. 2018. Fabrication of hyaluronidase-responsive biocompatible multilayers on BMP2 loaded titanium nanotube for the bacterial infection prevention. Mater. Sci. Eng. C 89:95–105
    [Google Scholar]
  123. 123. 
    Lin BJ, Wang J, Miao Y, Liu YQ, Jiang W et al. 2016. Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration. J. Mater. Chem. B 4:489–504
    [Google Scholar]
  124. 124. 
    Dafe A, Etemadi H, Zarredar H, Mahdavinia GR 2017. Development of novel carboxymethyl cellulose/k-carrageenan blends as an enteric delivery vehicle for probiotic bacteria. Int. J. Biol. Macromol. 97:299–307
    [Google Scholar]
  125. 125. 
    Wang M, Yang J, Li M, Wang Y, Wu H et al. 2019. Enhanced viability of layer-by-layer encapsulated Lactobacillus pentosus using chitosan and sodium phytate. Food Chem. 285:260–65
    [Google Scholar]
  126. 126. 
    Anselmo AC, McHugh KJ, Webster J, Langer R, Jaklenec A 2016. Layer-by-layer encapsulation of probiotics for delivery to the microbiome. Adv. Mater. 28:9486–90
    [Google Scholar]
  127. 127. 
    Zhang P, Chiu YC, Tostanoski LH, Jewell CM 2015. Polyelectrolyte multilayers assembled entirely from immune signals on gold nanoparticle templates promote antigen-specific T cell response. ACS Nano 9:6465–77
    [Google Scholar]
  128. 128. 
    He Y, Hong C, Li J, Howard MT, Li Y et al. 2018. Synthetic charge-invertible polymer for rapid and complete implantation of layer-by-layer microneedle drug films for enhanced transdermal vaccination. ACS Nano 12:10272–80
    [Google Scholar]
  129. 129. 
    Duong HTT, Yin Y, Thambi T, Nguyen TL, Giang Phan VH et al. 2018. Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy. Biomaterials 185:13–24
    [Google Scholar]
  130. 130. 
    He Y, Li J, Turvey ME, Funkenbusch MLT, Hong C et al. 2017. Synthetic lift-off polymer beneath layer-by-layer films for surface-mediated drug delivery. ACS Macro Lett. 6:1320–24
    [Google Scholar]
/content/journals/10.1146/annurev-bioeng-060418-052350
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