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Annual Review of Biomedical Engineering

Volume 19, 2017

Bioinspired Hydrogels to Engineer Cancer Microenvironments*

Abstract

Recent research has demonstrated that tumor microenvironments play pivotal roles in tumor development and metastasis through various physical, chemical, and biological factors, including extracellular matrix (ECM) composition, matrix remodeling, oxygen tension, pH, cytokines, and matrix stiffness. An emerging trend in cancer research involves the creation of engineered three-dimensional tumor models using bioinspired hydrogels that accurately recapitulate the native tumor microenvironment. With recent advances in materials engineering, many researchers are developing engineered tumor models, which are promising platforms for the study of cancer biology and for screening of therapeutic agents for better clinical outcomes. In this review, we discuss the development and use of polymeric hydrogel materials to engineer native tumor ECMs for cancer research, focusing on emerging technologies in cancer engineering that aim to accelerate clinical outcomes.

Keyword(s): cancer research, engineered tumor models, polymeric hydrogels, tumor microenvironments
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/content/journals/10.1146/annurev-bioeng-071516-044619
2017-06-21
2024-04-19
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/content/journals/10.1146/annurev-bioeng-071516-044619
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Bioinspired Hydrogels to Engineer Cancer Microenvironments*
Annual Review of Biomedical Engineering 19, 109 (2017); https://doi.org/10.1146/annurev-bioeng-071516-044619
/content/journals/10.1146/annurev-bioeng-071516-044619
/content/journals/10.1146/annurev-bioeng-071516-044619
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  • Article Type: Review Article

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