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Annual Review of Cell and Developmental Biology

Volume 34, 2018

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

Abstract

The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. The pathway comprises five core complexes: ALIX, ESCRT-I, ESCRT-II, ESCRT-III, and Vps4. These soluble complexes are typically recruited to target membranes by site-specific adaptors that bind one or both of the early-acting ESCRT factors: ALIX and ESCRT-I/ESCRT-II. These factors, in turn, nucleate assembly of ESCRT-III subunits into membrane-bound filaments that recruit the AAA ATPase Vps4. Together, ESCRT-III filaments and Vps4 remodel and sever membranes. Here, we review recent advances in our understanding of the structures, activities, and mechanisms of the ESCRT-III and Vps4 machinery, including the first high-resolution structures of ESCRT-III filaments, the assembled Vps4 enzyme in complex with an ESCRT-III substrate, the discovery that ESCRT-III/Vps4 complexes can promote both inside-out and outside-in membrane fission reactions, and emerging mechanistic models for ESCRT-mediated membrane fission.

Keyword(s): AAA ATPase, ESCRT pathway, ESCRT-III, membrane fission, membrane remodeling, Vps4
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2018-10-06
2024-04-20
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/content/journals/10.1146/annurev-cellbio-100616-060600
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Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes
Annual Review of Cell and Developmental Biology 34, 85 (2018); https://doi.org/10.1146/annurev-cellbio-100616-060600
/content/journals/10.1146/annurev-cellbio-100616-060600
/content/journals/10.1146/annurev-cellbio-100616-060600
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  • Article Type: Review Article

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