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Annual Review of Cell and Developmental Biology

Volume 37, 2021

Mechanobiology of T Cell Activation: To Catch a Bond

Abstract

T cell activation is a critical event in the adaptive immune response, indispensable for cell-mediated and humoral immunity as well as for immune regulation. Recent years have witnessed an emerging trend emphasizing the essential role that physical force and mechanical properties play at the T cell interface. In this review, we integrate current knowledge of T cell antigen recognition and the different models of T cell activation from the perspective of mechanobiology, focusing on the interaction between the T cell receptor (TCR) and the peptide–major histocompatibility complex (pMHC) antigen. We address the shortcomings of TCR affinity alone in explaining T cell functional outcomes and the rising status of force-regulated TCR bond lifetimes, most notably the TCR catch bond. Ultimately, T cell activation and the ensuing physiological responses result from mechanical interaction between TCRs and the pMHC.

Keyword(s): antigen recognition, force, mechanosensing, molecular dynamics simulation, T cell receptor, TCR catch bond, TCR:pMHC
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/content/journals/10.1146/annurev-cellbio-120219-055100
2021-10-06
2024-04-18
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/content/journals/10.1146/annurev-cellbio-120219-055100
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Mechanobiology of T Cell Activation: To Catch a Bond
Annual Review of Cell and Developmental Biology 37, 65 (2021); https://doi.org/10.1146/annurev-cellbio-120219-055100
/content/journals/10.1146/annurev-cellbio-120219-055100
/content/journals/10.1146/annurev-cellbio-120219-055100
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