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Annual Review of Genetics

Volume 52, 2018

The Multiple Levels of Mitonuclear Coregulation

Abstract

Together, the nuclear and mitochondrial genomes encode the oxidative phosphorylation (OXPHOS) complexes that reside in the mitochondrial inner membrane and enable aerobic life. Mitochondria maintain their own genome that is expressed and regulated by factors distinct from their nuclear counterparts. For optimal function, the cell must ensure proper stoichiometric production of OXPHOS subunits by coordinating two physically separated and evolutionarily distinct gene expression systems. Here, we review our current understanding of mitonuclear coregulation primarily at the levels of transcription and translation. Additionally, we discuss other levels of coregulation that may exist but remain largely unexplored, including mRNA modification and stability and posttranslational protein degradation.

Keyword(s): gene expression, mitochondria, mitonuclear balance, oxidative phosphorylation, transcription, translation
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2018-11-23
2024-04-20
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The Multiple Levels of Mitonuclear Coregulation
Annual Review of Genetics 52, 511 (2018); https://doi.org/10.1146/annurev-genet-120417-031709
/content/journals/10.1146/annurev-genet-120417-031709
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