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Annual Review of Immunology

Volume 37, 2019

Double-Stranded RNA Sensors and Modulators in Innate Immunity

Abstract

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity. This review aims to highlight their interconnectivity, as well as their commonalities and differences in their dsRNA recognition mechanisms.

Keyword(s): dsRNA, dsRNA-dependent adenosine deaminase, oligoadenylate synthase, protein kinase R, RIG-I-like receptor, RNA interference
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/content/journals/10.1146/annurev-immunol-042718-041356
2019-04-26
2024-04-25
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Double-Stranded RNA Sensors and Modulators in Innate Immunity
Annual Review of Immunology 37, 349 (2019); https://doi.org/10.1146/annurev-immunol-042718-041356
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