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Annual Review of Medicine

Volume 71, 2020

New Therapies for Emerging Endotypes of Asthma

Abstract

The presentation, pathobiology, and prognosis of asthma are highly heterogeneous and challenging for clinicians to diagnose and treat. In addition to the adaptive immune response that underlies allergic inflammation, innate immune mechanisms are increasingly recognized to be critical mediators of the eosinophilic airway inflammation present in most patients with asthma. Efforts to classify patients by severity and immune response have identified a number of different clinical and immune phenotypes, indicating that the innate and adaptive immune responses are differentially active among patients with the disease. Advances in the detection of these subgroups using clinical characteristics and biomarkers have led to the successful development of targeted biologics. This has moved us to a more personalized approach to managing asthma. Here we review the emerging endotypes of asthma and the biologics that have been developed to treat them.

Keyword(s): airway inflammation, airway remodeling, asthma, biologics, clustering analysis, endotypes, phenotype, sputum, T2 inflammation, transcriptomics
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/content/journals/10.1146/annurev-med-041818-020630
2020-01-27
2024-04-19
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/content/journals/10.1146/annurev-med-041818-020630
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New Therapies for Emerging Endotypes of Asthma
Annual Review of Medicine 71, 289 (2020); https://doi.org/10.1146/annurev-med-041818-020630
/content/journals/10.1146/annurev-med-041818-020630
/content/journals/10.1146/annurev-med-041818-020630
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