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Annual Review of Medicine

Volume 71, 2020

Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation

Abstract

The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications, and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality. These investigations are beginning to lead to clinical trials of microbiome-targeted interventions. Here we review some of these discoveries and describe strategies being investigated to manipulate the microbiome for favorable outcomes, such as the proper selection and timing of antibiotics, type of diet and route of administration, probiotics, prebiotics, and fecal microbiota transplantation.

Keyword(s): allo HCT, allogeneic hematopoietic cell transplant, antibiotics, febrile neutropenia, graft-versus-host disease, GVHD, microbiome, transplant-related mortality, TRM
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/content/journals/10.1146/annurev-med-052918-122440
2020-01-27
2024-04-16
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/content/journals/10.1146/annurev-med-052918-122440
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Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation
Annual Review of Medicine 71, 137 (2020); https://doi.org/10.1146/annurev-med-052918-122440
/content/journals/10.1146/annurev-med-052918-122440
/content/journals/10.1146/annurev-med-052918-122440
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