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Annual Review of Nutrition

Volume 38, 2018

Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol

Abstract

Both acute intoxication and longer-term cumulative ingestion of alcohol negatively impact the metabolic phenotype of both skeletal and cardiac muscle, independent of overt protein calorie malnutrition, resulting in loss of skeletal muscle strength and cardiac contractility. In large part, these alcohol-induced changes are mediated by a decrease in protein synthesis that in turn is governed by impaired activity of a protein kinase, the mechanistic target of rapamycin (mTOR). Herein, we summarize recent advances in understanding mTOR signal transduction, similarities and differences between the effects of alcohol on this central metabolic controller in skeletal muscle and in the heart, and the effects of acute versus chronic alcohol intake. While alcohol-induced alterations in global proteolysis via activation of the ubiquitin-proteasome pathway are equivocal, emerging data suggest alcohol increases autophagy in muscle. Further studies are necessary to define the relative contributions of these bidirectional changes in protein synthesis and autophagy in the etiology of alcoholic myopathy in skeletal muscle and the heart.

Keyword(s): alcoholic myopathy, amino acids, autophagy, mTOR, protein synthesis, translational control, ubiquitin-proteasome pathway
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/content/journals/10.1146/annurev-nutr-071816-064642
2018-08-21
2024-04-25
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Literature Cited

  1. 1.  Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH 2016. Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence. Am. J. Physiol. Endocrinol. Metab. 311:E594–604
     [Google Scholar]
  2. 2.  Bento CF, Renna M, Ghislat G, Puri C, Ashkenazi A et al. 2016. Mammalian autophagy: How does it work?. Annu. Rev. Biochem. 85:685–713
     [Google Scholar]
  3. 3.  Bernal CA, Vazquez JA, Adibi SA 1993. Leucine metabolism during chronic ethanol consumption. Metab. Clin. Exp. 42:1084–86
     [Google Scholar]
  4. 4.  Broer S, Broer A 2017. Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem. J. 474:1935–63
     [Google Scholar]
  5. 5.  Buerger C, DeVries B, Stambolic V 2006. Localization of Rheb to the endomembrane is critical for its signaling function. Biochem. Biophys. Res. Commun. 344:869–80
     [Google Scholar]
  6. 6.  Cai S-L, Tee AR, Short JD, Bergeron JM, Kim J et al. 2006. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J. Cell Biol. 173:279–89
     [Google Scholar]
  7. 7.  Castro AF, Rebhun JF, Clark GJ, Quilliam LA 2003. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 278:32493–96
     [Google Scholar]
  8. 8.  Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K et al. 2016. The CASTOR proteins are arginine sensors for the mTORC1 pathway. Cell 165:153–64
     [Google Scholar]
  9. 9.  Clark GJ, Kinch MS, Rogers-Graham K, Sebti SM, Hamilton AD, Der CJ 1997. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem. 272:10608–15
     [Google Scholar]
  10. 10.  Collins GA, Goldberg AL 2017. The logic of the 26S proteasome. Cell 169:792–806
     [Google Scholar]
  11. 11.  Dennis MD, Baum JI, Kimball SR, Jefferson LS 2011. Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. J. Biol. Chem. 286:8287–96
     [Google Scholar]
  12. 12.  Dennis MD, Jefferson LS, Kimball SR 2012. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J. Biol. Chem. 287:42890–99
     [Google Scholar]
  13. 13.  Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H et al. 2013. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 493:679–83
     [Google Scholar]
  14. 14.  El-Mas MM, Abdel-Rahman AA 2015. Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats. Toxicol. Appl. Pharmacol. 287:284–92
     [Google Scholar]
  15. 15.  Estruch R, Sacanella E, Fernandez-Sola J, Nicolas JM, Rubin E, Urbano-Marquez A 1998. Natural history of alcoholic myopathy: a 5-year study. Alcohol. Clin. Exp. Res. 22:2023–28
     [Google Scholar]
  16. 16.  Fernandez-Sola J, Sacanella E, Estruch R, Nicolas JM, Grau JM, Urbano-Marquez A 1995. Significance of type II fiber atrophy in chronic alcoholic myopathy. J. Neurol Sci. 130:69–76
     [Google Scholar]
  17. 17.  Gao L, Zhang X, Wang FR, Cao MF, Zhang XJ et al. 2010. Chronic ethanol consumption up-regulates protein-tyrosine phosphatase-1B (PTP1B) expression in rat skeletal muscle. Acta Pharmacol. Sin. 31:1576–82
     [Google Scholar]
  18. 18.  Garami A, Zwartkruis FJT, Nobukuni T, Joaquin M, Roccio M et al. 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP1 signaling, is inhibited by TSC1 and 2. Mol. Cell 11:1457–66
     [Google Scholar]
  19. 19.  Ge W, Guo R, Ren J 2011. AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. Free Radic. Biol. Med. 51:1736–48
     [Google Scholar]
  20. 20.  Ge W, Li Q, Turdi S, Wang XM, Ren J 2011. Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK. J. Cell. Mol. Med. 15:1737–46
     [Google Scholar]
  21. 21.  Gilmore W, Chikritzhs T, Stockwell T, Jernigan D, Naimi T, Gilmore I 2016. Alcohol: taking a population perspective. Nat. Rev. Gastroenterol. Hepatol. 13:426–34
     [Google Scholar]
  22. 22.  Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY et al. 2017. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science 358:813–18
     [Google Scholar]
  23. 23.  Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY et al. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1. Dev. Cell 11:859–71
     [Google Scholar]
  24. 24.  Guo R, Hu N, Kandadi MR, Ren J 2012. Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts. Autophagy 8:593–608
     [Google Scholar]
  25. 25.  Guo R, Ren J 2012. Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation. Cardiovasc. Res. 94:480–91
     [Google Scholar]
  26. 26.  Hanid A, Slavin G, Mair W, Sowter C, Ward P et al. 1981. Fibre type changes in striated muscle of alcoholics. J. Clin. Pathol. 34:991–95
     [Google Scholar]
  27. 27.  Hingson RW, Zha W, White AM 2017. Drinking beyond the binge threshold: predictors, consequences, and changes in the U.S. Am. J. Prev. Med. 52:717–27
     [Google Scholar]
  28. 28.  Hinnebusch AG 2017. Structural insights into the mechanism of scanning and start codon recognition in eukaryotic translation initiation. Trends Biochem. Sci. 42:589–611
     [Google Scholar]
  29. 29.  Hong-Brown LQ, Brown CR, Huber DS, Lang CH 2007. Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes. J. Biol. Chem. 282:3702–12
     [Google Scholar]
  30. 30.  Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH 2010. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. J. Cell. Biochem. 109:1172–84
     [Google Scholar]
  31. 31.  Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH 2012. Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am. J. Physiol. Cell Physiol. 302:C1557–65
     [Google Scholar]
  32. 32.  Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH 2017. FoxO1-AMPK-ULK1 regulates ethanol-induced autophagy in muscle by enhanced ATG14 association with the BECN1-PIK3C3 complex. Alcohol. Clin. Exp. Res. 41:895–910
     [Google Scholar]
  33. 33.  Hong-Brown LQ, Frost RA, Lang CH 2001. Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells. Alcohol. Clin. Exp. Res. 25:1373–82
     [Google Scholar]
  34. 34.  Hunter RJ, Neagoe C, Jarvelainen HA, Martin CR, Lindros KO et al. 2003. Alcohol affects the skeletal muscle proteins, titin and nebulin in male and female rats. J. Nutr. 133:1154–57
     [Google Scholar]
  35. 35.  Inoki K, Li Y, Xu T, Guan K-L 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes. Dev. 17:1829–34
     [Google Scholar]
  36. 36.  Inoki K, Li Y, Zhu T, Wu J, Guan K-L 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 4:648–57
     [Google Scholar]
  37. 37.  Jacinto E, Facchinetti V, Liu D, Soto N, Wei S et al. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127:125–37
     [Google Scholar]
  38. 38.  Jayasekara H, English DR, Room R, MacInnis RJ 2014. Alcohol consumption over time and risk of death: a systematic review and meta-analysis. Am. J. Epidemiol. 179:1049–59
     [Google Scholar]
  39. 39.  Jelic P, Shih MF, Taberner PV 1998. Diurnal variation in plasma ethanol levels of TO and CBA mice on chronic ethanol drinking or ethanol liquid diet schedules. Psychopharmacology 138:143–50
     [Google Scholar]
  40. 40.  Kandadi MR, Hu N, Ren J 2013. ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge. Curr. Pharm. Des. 19:4874–87
     [Google Scholar]
  41. 41.  Kaur J, Debnath J 2015. Autophagy at the crossroads of catabolism and anabolism. Nat. Rev. Mol. Cell Biol. 16:461–72
     [Google Scholar]
  42. 42.  Kim J, Kundu M, Viollet B, Guan KL 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13:132–41
     [Google Scholar]
  43. 43.  Kim YM, Jung CH, Seo M, Kim EK, Park JM et al. 2015. mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. Mol. Cell 57:207–18
     [Google Scholar]
  44. 44.  Koll M, Ahmed S, Mantle D, Donohue TM, Palmer TN et al. 2002. Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo. Metabolism 51:97–104
     [Google Scholar]
  45. 45.  Korzick DH, Sharda DR, Pruznak AM, Lang CH 2013. Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304:R887–98
     [Google Scholar]
  46. 46.  Kumar V, Frost RA, Lang CH 2002. Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 283:E917–28
     [Google Scholar]
  47. 47.  Lang CH, Derdak Z, Wands JR 2014. Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol. Alcohol. Clin. Exp. Res. 38:897–910
     [Google Scholar]
  48. 48.  Lang CH, Fan J, Lipton BP, Potter BJ, McDonough KH 1998. Modulation of the insulin-like growth factor system by chronic alcohol feeding. Alcohol. Clin. Exp. Res. 22:823–29
     [Google Scholar]
  49. 49.  Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC et al. 2003. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 285:E1205–15
     [Google Scholar]
  50. 50.  Lang CH, Frost RA, Kumar V, Vary TC 2000. Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F. Am. J. Physiol. Endocrinol. Metab. 279:E1029–38
     [Google Scholar]
  51. 51.  Lang CH, Frost RA, Kumar V, Wu D, Vary TC 2000. Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver. Alcohol. Clin. Exp. Res. 24:322–31
     [Google Scholar]
  52. 52.  Lang CH, Frost RA, Summer AD, Vary TC 2005. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Int. J. Biochem. Cell Biol. 37:2180–95
     [Google Scholar]
  53. 53.  Lang CH, Frost RA, Svanberg E, Vary TC 2004. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am. J. Physiol. Endocrinol. Metab. 286:E916–26
     [Google Scholar]
  54. 54.  Lang CH, Frost RA, Vary TC 2007. Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Am. J. Physiol. Endocrinol. Metab. 292:E1497–506
     [Google Scholar]
  55. 55.  Lang CH, Frost RA, Vary TC 2008. Acute alcohol intoxication increases REDD1 in skeletal muscle. Alcohol. Clin. Exp. Res. 32:796–805
     [Google Scholar]
  56. 56.  Lang CH, Kimball SR, Frost RA, Vary TC 2001. Alcohol myopathy: impairment of protein synthesis and translation initiation. Int. J. Biochem. Cell Biol. 33:457–73
     [Google Scholar]
  57. 57.  Lang CH, Korzick DH 2014. Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306:R23–33
     [Google Scholar]
  58. 58.  Lang CH, Kumar V, Liu X, Frost RA, Vary TC 2003. IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication. Alcohol. Clin. Exp. Res. 27:485–94
     [Google Scholar]
  59. 59.  Lang CH, Lynch CJ, Vary TC 2010. Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. J. Nutr. 140:932–38
     [Google Scholar]
  60. 60.  Lang CH, Pruznak AM, Deshpande N, Palopoli MM, Frost RA, Vary TC 2004. Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Alcohol. Clin. Exp. Res. 28:1758–67
     [Google Scholar]
  61. 61.  Lang CH, Pruznak AM, Nystrom GJ, Vary TC 2009. Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: comparable effects in young and mature rats. Nutr. Metab. 6:4
     [Google Scholar]
  62. 62.  Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC 1999. Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. Am. J. Physiol. 277:E268–76
     [Google Scholar]
  63. 63.  Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ et al. 2012. Distinct perturbation of the translatome by the antidiabetic drug metformin. PNAS 109:8977–82
     [Google Scholar]
  64. 64.  Li SY, Gilbert SA, Li Q, Ren J 2009. Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress. J. Mol. Cell. Cardiol. 47:247–55
     [Google Scholar]
  65. 65.  Liang C, Lee JS, Inn KS, Gack MU, Li Q et al. 2008. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 10:776–87
     [Google Scholar]
  66. 66.  Lieber CS 2000. Alcohol: its metabolism and interaction with nutrients. Annu. Rev. Nutr. 20:395–430
     [Google Scholar]
  67. 67.  Liu P, Gan W, Chin YR, Ogura K, Guo J et al. 2015. PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex. Cancer Discov 5:1194–209
     [Google Scholar]
  68. 68.  Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN et al. 2007. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res 67:7106–12
     [Google Scholar]
  69. 69.  Manning BD, Toker A 2017. AKT/PKB signaling: navigating the network. Cell 169:381–405
     [Google Scholar]
  70. 70.  Martin FC, Peters TJ 1985. Assessment in vitro and in vivo of muscle degradation in chronic skeletal muscle myopathy of alcoholism. Clin. Sci. 68:693–700
     [Google Scholar]
  71. 71.  Molina PE, McNurlan M, Rathmacher J, Lang CH, Zambell KL et al. 2006. Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection. Alcohol. Clin. Exp. Res. 30:2065–78
     [Google Scholar]
  72. 72.  Moro T, Ebert SM, Adams CM, Rasmussen BB 2016. Amino acid sensing in skeletal muscle. Trends Endocrinol. Metab. 27:796–806
     [Google Scholar]
  73. 73.  Nguyen VA, Le T, Tong M, Silbermann E, Gundogan F, de la Monte SM 2012. Impaired insulin/IGF signaling in experimental alcohol-related myopathy. Nutrients 4:1058–75
     [Google Scholar]
  74. 74.  Nicolas JM, Garcia G, Fatjo F, Sacanella E, Tobias E et al. 2003. Influence of nutritional status on alcoholic myopathy. Am. J. Clin. Nutr. 78:326–33
     [Google Scholar]
  75. 75.  Nunez NP, Carter PA, Meadows GG 2002. Alcohol consumption promotes body weight loss in melanoma-bearing mice. Alcohol. Clin. Exp. Res. 26:617–26
     [Google Scholar]
  76. 76.  Otis JS, Brown LA, Guidot DM 2007. Oxidant-induced atrogin-1 and transforming growth factor-β1 precede alcohol-related myopathy in rats. Muscle Nerve 36:842–48
     [Google Scholar]
  77. 77.  Otis JS, Guidot DM 2009. Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats. Alcohol. Clin. Exp. Res. 33:1450–59
     [Google Scholar]
  78. 78.  Pacy PJ, Preedy VR, Peters TJ, Read M, Halliday D 1991. The effect of chronic alcohol ingestion on whole body and muscle protein synthesis—a stable isotope study. Alcohol Alcohol 26:505–13
     [Google Scholar]
  79. 79.  Patel VB, Siddiq T, Richardson PJ, Preedy VR 2000. Alcohol-induced reductions in cardiac protein synthesis in vivo are not ameliorated by treatment with the dihydropyridine calcium channel blocker amlodipine. Alcohol. Clin. Exp. Res. 24:727–32
     [Google Scholar]
  80. 80.  Pearce LR, Komander D, Alessi DR 2010. The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11:9–22
     [Google Scholar]
  81. 81.  Pelletier J, Graff J, Ruggero D, Sonenberg N 2015. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res 75:250–63
     [Google Scholar]
  82. 82.  Peng M, Yin N, Li MO 2014. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 159:122–33
     [Google Scholar]
  83. 83.  Piano MR, Phillips SA 2014. Alcoholic cardiomyopathy: pathophysiologic insights. Cardiovasc. Toxicol. 14:291–308
     [Google Scholar]
  84. 84.  Preedy VR, Adachi J, Asano M, Koll M, Mantle D et al. 2002. Free radicals in alcoholic myopathy: indices of damage and preventive studies. Free Radic. Biol. Med. 32:683–87
     [Google Scholar]
  85. 85.  Preedy VR, Keating JW, Peters TJ 1992. The acute effects of ethanol and acetaldehyde on rates of protein synthesis in type I and type II fibre-rich skeletal muscles of the rat. Alcohol Alcohol 27:241–51
     [Google Scholar]
  86. 86.  Preedy VR, Macallan DC, Griffin GE, Cook EB, Palmer TN, Peters TJ 1997. Total contractile protein contents and gene expression in skeletal muscle in response to chronic ethanol consumption in the rat. Alcohol 14:545–49
     [Google Scholar]
  87. 87.  Preedy VR, Peters TJ 1988. The effect of chronic ethanol feeding on body and plasma composition and rates of skeletal muscle protein turnover in the rat. Alcohol Alcohol 23:217–24
     [Google Scholar]
  88. 88.  Preedy VR, Peters TJ 1990. Changes in protein, RNA and DNA and rates of protein synthesis in muscle-containing tissues of the mature rat in response to ethanol feeding: a comparative study of heart, small intestine and gastrocnemius muscle. Alcohol Alcohol 25:489–98
     [Google Scholar]
  89. 89.  Preedy VR, Salisbury JR, Peters TJ 1994. Alcoholic muscle disease: features and mechanisms. J. Pathol. 173:309–15
     [Google Scholar]
  90. 90.  Reilly ME, Mantle D, Richardson PJ, Salisbury J, Jones J et al. 1997. Studies on the time-course of ethanol's acute effects on skeletal muscle protein synthesis: comparison with acute changes in proteolytic activity. Alcohol. Clin. Exp. Res. 21:792–98
     [Google Scholar]
  91. 91.  Reilly ME, McKoy G, Mantle D, Peters TJ, Goldspink G, Preedy VR 2000. Protein and mRNA levels of the myosin heavy chain isoforms Ibeta, IIa, IIx and IIb in type I and type II fibre-predominant rat skeletal muscles in response to chronic alcohol feeding. J. Muscle Res. Cell Motil. 21:763–73
     [Google Scholar]
  92. 92.  Reinus JF, Heymsfield SB, Wiskind R, Casper K, Galambos JT 1989. Ethanol: relative fuel value and metabolic effects in vivo. Metabolism 38:125–35
     [Google Scholar]
  93. 93.  Roccio M, Bos JL, Zwartkruis FJT 2005. Regulation of the small GTPase Rheb by amino acids. Oncogene 25:657–64
     [Google Scholar]
  94. 94.  Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J 2004. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. PNAS 101:13489–94
     [Google Scholar]
  95. 95.  Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC et al. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496–501
     [Google Scholar]
  96. 96.  Sato T, Nakashima A, Guo L, Tamanoi F 2009. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J. Biol. Chem. 284:12783–91
     [Google Scholar]
  97. 97.  Siddiq T, Salisbury JR, Richardson PJ, Preedy VR 1993. Synthesis of ventricular mitochondrial proteins in vivo: effect of acute ethanol toxicity. Alcohol. Clin. Exp. Res. 17:894–99
     [Google Scholar]
  98. 98.  Simon L, LeCapitaine N, Berner P, Vande Stouwe C, Mussell JC et al. 2014. Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306:R837–44
     [Google Scholar]
  99. 99.  Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG 2005. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280:18717–27
     [Google Scholar]
  100. 100.  Sneddon AA, Koll M, Wallace MC, Jones J, Miell JP et al. 2003. Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 284:E874–82
     [Google Scholar]
  101. 101.  Sonntag WE, Boyd RL 1989. Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcohol. Clin. Exp. Res. 13:3–7
     [Google Scholar]
  102. 102.  Steiner JL, Crowell KT, Lang CH 2015. Impact of alcohol on glycemic control and insulin action. Biomolecules 5:2223–46
     [Google Scholar]
  103. 103.  Steiner JL, Gordon BS, Lang CH 2015. Moderate alcohol consumption does not impair overload-induced muscle hypertrophy and protein synthesis. Physiol. Rep. 3:3e12333
     [Google Scholar]
  104. 104.  Steiner JL, Kimball SR, Lang CH 2016. Acute alcohol-induced decrease in muscle protein synthesis in female mice is REDD-1 and mTOR-independent. Alcohol Alcohol 51:242–50
     [Google Scholar]
  105. 105.  Steiner JL, Lang CH 2014. Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction. J. Appl. Physiol. 117:1170–79
     [Google Scholar]
  106. 106.  Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J 2003. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:1259–68
     [Google Scholar]
  107. 107.  Thapaliya S, Runkana A, McMullen MR, Nagy LE, McDonald C et al. 2014. Alcohol-induced autophagy contributes to loss in skeletal muscle mass. Autophagy 10:677–90
     [Google Scholar]
  108. 108.  Thavorncharoensap M, Teerawattananon Y, Yothasamut J, Lertpitakpong C, Chaikledkaew U 2009. The economic impact of alcohol consumption: a systematic review. Subst. Abuse Treat. Prev. Policy 4:20
     [Google Scholar]
  109. 109.  Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM 2012. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485:109–13
     [Google Scholar]
  110. 110.  Urbano-Marquez A, Estruch R, Fernandez-Sola J, Nicolas JM, Pare JC, Rubin E 1995. The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. JAMA 274:149–54
     [Google Scholar]
  111. 111.  Vary T 2009. Oral leucine enhances myocardial protein synthesis in rats acutely administered ethanol. J. Nutr. 139:1439–44
     [Google Scholar]
  112. 112.  Vary TC, Deiter G 2005. Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart. Metabolism 54:212–19
     [Google Scholar]
  113. 113.  Vary TC, Frost RA, Lang CH 2008. Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R1777–89
     [Google Scholar]
  114. 114.  Vary TC, Kimball SR, Sumner A 2007. Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292:R778–87
     [Google Scholar]
  115. 115.  Vary TC, Lang CH 2008. Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. Cardiovasc. Toxicol. 8:23–32
     [Google Scholar]
  116. 116.  Vary TC, Lynch CJ, Lang CH 2001. Effects of chronic alcohol consumption on regulation of myocardial protein synthesis. Am. J. Physiol. Heart Circ. Physiol. 281:H1242–51
     [Google Scholar]
  117. 117.  Vary TC, Nairn AC, Deiter G, Lang CH 2002. Differential effects of alcohol consumption on eukaryotic elongation factors in heart, skeletal muscle, and liver. Alcohol. Clin. Exp. Res. 26:1794–802
     [Google Scholar]
  118. 118.  Vary TC, Nairn AC, Lang CH 2004. Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol. Alcohol. Clin. Exp. Res. 28:517–25
     [Google Scholar]
  119. 119.  Wilkens Knudsen A, Jensen JE, Nordgaard-Lassen I, Almdal T, Kondrup J, Becker U 2014. Nutritional intake and status in persons with alcohol dependency: data from an outpatient treatment programme. Eur. J. Nutr. 53:1483–92
     [Google Scholar]
  120. 120.  Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM et al. 2015. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351:43–48
     [Google Scholar]
  121. 121.  Wolfson RL, Sabatini DM 2017. The dawn of the age of amino acid sensors for the mTORC1 pathway. Cell Metab 26:301–9
     [Google Scholar]
  122. 122.  Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5:578–81
     [Google Scholar]
/content/journals/10.1146/annurev-nutr-071816-064642
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Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol
Annual Review of Nutrition 38, 197 (2018); https://doi.org/10.1146/annurev-nutr-071816-064642
/content/journals/10.1146/annurev-nutr-071816-064642
/content/journals/10.1146/annurev-nutr-071816-064642
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