1932

Abstract

Proper timing of critical care nutrition has long been a matter of controversy. Critical illness waxes and wanes in stages, creating a dynamic flux in energy needs that we have only begun to examine. Furthermore, response to nutrition support likely differs greatly at the level of the individual patient in regard to genetic status, disease stage, comorbidities, and more. We review the observational and randomized literature concerning timing in nutrition support, discuss mechanisms of harm in feeding critically ill patients, and highlight the role of precision nutrition for moving the literature beyond the realm of blunt population averages into one that accounts for the patient-specific complexities of critical illness and host genetics.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-nutr-111120-114108
2021-10-11
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/nutr/41/1/annurev-nutr-111120-114108.html?itemId=/content/journals/10.1146/annurev-nutr-111120-114108&mimeType=html&fmt=ahah

Literature Cited

  1. 1. 
    Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG et al. 2009. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 35:1728–37
    [Google Scholar]
  2. 2. 
    Ali Abdelhamid Y, Cousins CE, Sim JA, Bellon MS, Nguyen NQ et al. 2015. Effect of critical illness on triglyceride absorption. J. Parenter. Enteral. Nutr. 39:966–72
    [Google Scholar]
  3. 3. 
    Allingstrup MJ, Kondrup J, Wiis J, Claudius C, Pedersen UG et al. 2017. Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med 43:1637–47
    [Google Scholar]
  4. 4. 
    Altintas ND, Aydin K, Turkoglu MA, Abbasoglu O, Topeli A. 2011. Effect of enteral versus parenteral nutrition on outcome of medical patients requiring mechanical ventilation. Nutr. Clin. Pract. 26:322–29
    [Google Scholar]
  5. 5. 
    Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM et al. 2015. Permissive underfeeding or standard enteral feeding in critically ill adults. N. Engl. J. Med. 372:2398–408
    [Google Scholar]
  6. 6. 
    Arabi YM, Haddad SH, Tamim HM, Rishu AH, Sakkijha MH et al. 2010. Near-target caloric intake in critically ill medical-surgical patients is associated with adverse outcomes. J. Parenter. Enteral. Nutr. 34:280–88
    [Google Scholar]
  7. 7. 
    Arabi YM, Tamim HM, Dhar GS, Al-Dawood A, Al-Sultan M et al. 2011. Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am. J. Clin. Nutr. 93:569–77
    [Google Scholar]
  8. 8. 
    Braunschweig CA, Sheean PM, Peterson SJ, Gomez Perez S, Freels S et al. 2015. Intensive nutrition in acute lung injury: a clinical trial (INTACT). J. Parenter. Enteral. Nutr. 39:13–20
    [Google Scholar]
  9. 9. 
    Braunschweig CL, Freels S, Sheean PM, Peterson SJ, Perez SG et al. 2017. Role of timing and dose of energy received in patients with acute lung injury on mortality in the Intensive Nutrition in Acute Lung Injury Trial (INTACT): a post hoc analysis. Am. J. Clin. Nutr. 105:411–16
    [Google Scholar]
  10. 10. 
    Bryant LK, Fraser RJ, Vozzo R, Zacharakis B, Matthews GM, Butler R. 2004. Stimulation of small intestinal burst activity in the postprandial state differentially affects lipid and glucose absorption in healthy adult humans. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G1028–1028
    [Google Scholar]
  11. 11. 
    Cahill NE, Murch L, Jeejeebhoy K, McClave SA, Day AG et al. 2011. When early enteral feeding is not possible in critically ill patients: results of a multicenter observational study. J. Parenter. Enteral. Nutr. 35:160–68
    [Google Scholar]
  12. 12. 
    Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M et al. 2011. Early versus late parenteral nutrition in critically ill adults. N. Engl. J. Med. 365:506–17
    [Google Scholar]
  13. 13. 
    Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G. 2013. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am. J. Respir. Crit. Care Med. 187:247–55
    [Google Scholar]
  14. 14. 
    Chakraborty RK, Burns B. 2021. Systemic inflammatory response syndrome. StatPearls Treasure Island, FL: StatPearls Publ.
    [Google Scholar]
  15. 15. 
    Charles EJ, Petroze RT, Metzger R, Hranjec T, Rosenberger LH et al. 2014. Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial. Am. J. Clin. Nutr. 100:1337–43
    [Google Scholar]
  16. 16. 
    Compher C, Chittams J, Sammarco T, Nicolo M, Heyland DK. 2017. Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter, multinational observational study. Crit. Care Med. 45:156–63
    [Google Scholar]
  17. 17. 
    Costa NA, Gut AL, Azevedo PS, Fernandes AAH, Polegato BF et al. 2019. Protein carbonyl, but not malondialdehyde, is associated with ICU mortality in patients with septic shock. J. Intensive Care Med. 34:669–73
    [Google Scholar]
  18. 18. 
    Cuthbertson DP, Angeles Valero Zanuy MA, León Sanz ML. 2001. Post-shock metabolic response; 1942. Nutr. Hosp. 16:176–82
    [Google Scholar]
  19. 19. 
    De Waele E, Malbrain M, Spapen H. 2020. Nutrition in sepsis: a bench-to-bedside review. Nutrients 12:2395
    [Google Scholar]
  20. 20. 
    Deane AM, Rayner CK, Keeshan A, Cvijanovic N, Marino Z et al. 2014. The effects of critical illness on intestinal glucose sensing, transporters, and absorption. Crit. Care Med. 42:57–65
    [Google Scholar]
  21. 21. 
    Deane AM, Summers MJ, Zaknic AV, Chapman MJ, Di Bartolomeo AE et al. 2011. Glucose absorption and small intestinal transit in critical illness. Crit. Care Med. 39:1282–88
    [Google Scholar]
  22. 22. 
    Delgado-Lista J, Perez-Martinez P, Solivera J, Garcia-Rios A, Perez-Caballero AI et al. 2014. Top single nucleotide polymorphisms affecting carbohydrate metabolism in metabolic syndrome: from the LIPGENE study. J. Clin. Endocrinol. Metab. 99:E384–384
    [Google Scholar]
  23. 23. 
    Dive A, Moulart M, Jonard P, Jamart J, Mahieu P. 1994. Gastroduodenal motility in mechanically ventilated critically ill patients: a manometric study. Crit. Care Med. 22:441–47
    [Google Scholar]
  24. 24. 
    Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D et al. 2015. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir. Med. 3:943–52
    [Google Scholar]
  25. 25. 
    Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ et al. 2013. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 309:2130–38
    [Google Scholar]
  26. 26. 
    Dvir D, Cohen J, Singer P. 2006. Computerized energy balance and complications in critically ill patients: an observational study. Clin. Nutr. 25:37–44
    [Google Scholar]
  27. 27. 
    Elke G, Wang M, Weiler N, Day AG, Heyland DK. 2014. Close to recommended caloric and protein intake by enteral nutrition is associated with better clinical outcome of critically ill septic patients: secondary analysis of a large international nutrition database. Crit. Care 18:R29
    [Google Scholar]
  28. 28. 
    Faisy C, Lerolle N, Dachraoui F, Savard JF, Abboud I et al. 2009. Impact of energy deficit calculated by a predictive method on outcome in medical patients requiring prolonged acute mechanical ventilation. Br. J. Nutr. 101:1079–87
    [Google Scholar]
  29. 29. 
    Funke S, Risch A, Nieters A, Hoffmeister M, Stegmaier C et al. 2009. Genetic polymorphisms in genes related to oxidative stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and survival of rectal cancer patients after radiotherapy. J. Cancer Epidemiol. 2009:302047
    [Google Scholar]
  30. 30. 
    Halliwell B, Gutteridge JMC. 2015. Free Radicals in Biology and Medicine Oxford, UK: Oxford Univ. Press
  31. 31. 
    Hartl WH, Bender A, Scheipl F, Kuppinger D, Day AG, Kuchenhoff H. 2019. Calorie intake and short-term survival of critically ill patients. Clin. Nutr. 38:660–67
    [Google Scholar]
  32. 32. 
    Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E et al. 2014. Trial of the route of early nutritional support in critically ill adults. N. Engl. J. Med. 371:1673–84
    [Google Scholar]
  33. 33. 
    He C, Qureshi AA, Han J 2010. Polymorphisms in genes involved in oxidative stress and their interactions with lifestyle factors on skin cancer risk. J. Dermatol. Sci. 60:54–56
    [Google Scholar]
  34. 34. 
    Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P et al. 2013. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 381:385–93
    [Google Scholar]
  35. 35. 
    Hermans G, Casaer MP, Clerckx B, Guiza F, Vanhullebusch T et al. 2013. Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. Lancet Respir. Med. 1:621–29
    [Google Scholar]
  36. 36. 
    Hernandez-Guerrero C, Parra-Carriedo A, Ruiz-de-Santiago D, Galicia-Castillo O, Buenrostro-Jauregui M, Diaz-Gutierrez C. 2018. Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention. Genes Nutr 13:1
    [Google Scholar]
  37. 37. 
    Hu Y, Benya RV, Carroll RE, Diamond AM. 2005. Allelic loss of the gene for the GPX1 selenium-containing protein is a common event in cancer. J. Nutr. 135:3021S–24S
    [Google Scholar]
  38. 38. 
    Hu YJ, Diamond AM. 2003. Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer Res 63:3347–51
    [Google Scholar]
  39. 39. 
    Knaus WA, Draper EA, Wagner DP, Zimmerman JE. 1985. APACHE II: a severity of disease classification system. Crit. Care Med. 13:818–29
    [Google Scholar]
  40. 40. 
    Koretz RL. 2015. JPEN journal club 12. Selective outcome reporting. J. Parenter. Enteral. Nutr. 39:489–91
    [Google Scholar]
  41. 41. 
    Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H. 1993. Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit. Care Med. 21:1012–19
    [Google Scholar]
  42. 42. 
    Krishnan JA, Parce PB, Martinez A, Diette GB, Brower RG. 2003. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest 124:297–305
    [Google Scholar]
  43. 43. 
    Kutsogiannis J, Alberda C, Gramlich L, Cahill NE, Wang M et al. 2011. Early use of supplemental parenteral nutrition in critically ill patients: results of an international multicenter observational study. Crit. Care Med. 39:2691–99
    [Google Scholar]
  44. 44. 
    Lambell KJ, Tatucu-Babet OA, Chapple LA, Gantner D, Ridley EJ. 2020. Nutrition therapy in critical illness: a review of the literature for clinicians. Crit. Care 24:35
    [Google Scholar]
  45. 45. 
    Langouche L, Vander Perre S, Marques M, Boelen A, Wouters PJ et al. 2013. Impact of early nutrient restriction during critical illness on the nonthyroidal illness syndrome and its relation with outcome: a randomized, controlled clinical study. J. Clin. Endocrinol. Metab. 98:1006–13
    [Google Scholar]
  46. 46. 
    Liu Z, Triba MN, Amathieu R, Lin X, Bouchemal N et al. 2019. Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors. Crit. Care 23:169
    [Google Scholar]
  47. 47. 
    Lorente L, Martin MM, Abreu-Gonzalez P, Dominguez-Rodriguez A, Labarta L et al. 2013. Prognostic value of malondialdehyde serum levels in severe sepsis: a multicenter study. PLOS ONE 8:e53741
    [Google Scholar]
  48. 48. 
    Lorente L, Martin MM, Abreu-Gonzalez P, Dominguez-Rodriguez A, Labarta L et al. 2013. Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients. Crit. Care 17:R290
    [Google Scholar]
  49. 49. 
    Lorente L, Martin MM, Almeida T, Abreu-Gonzalez P, Ferreres J et al. 2015. Association between serum total antioxidant capacity and mortality in severe septic patients. J. Crit. Care 30:217.e7–12
    [Google Scholar]
  50. 50. 
    Lorente L, Martin MM, Perez-Cejas A, Abreu-Gonzalez P, Lopez RO et al. 2018. Serum total antioxidant capacity during the first week of sepsis and mortality. J. Crit. Care 47:139–44
    [Google Scholar]
  51. 51. 
    Majolo F, Oliveira Paludo FJ, Ponzoni A, Graebin P, Dias FS, Alho CS. 2015. Effect of 593C >T GPx1 SNP alone and in synergy with 47C >T SOD2 SNP on the outcome of critically ill patients. Cytokine 71:312–17
    [Google Scholar]
  52. 52. 
    McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR et al. 2016. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). J. Parenter. Enteral. Nutr 40:159–211
    [Google Scholar]
  53. 53. 
    McKeever L, Bonini M, Braunschweig C. 2018. Feeding during phases of altered mitochondrial activity: a theory. J. Parenter. Enteral. Nutr. 42:855–63
    [Google Scholar]
  54. 54. 
    McKeever L, Peterson SJ, Cienfuegos S, Rizzie J, Lateef O et al. 2020. Real-time energy exposure is associated with increased oxidative stress among feeding-tolerant critically ill patients: results from the FEDOX trial. J. Parenter. Enteral. Nutr. 44:81484–91
    [Google Scholar]
  55. 55. 
    McKeever L, Peterson SJ, Lateef O, Freels S, Fonseca TL et al. 2019. Higher caloric exposure in critically ill patients transiently accelerates thyroid hormone activation. J. Clin. Endocrinol. Metab. 105:2523–33
    [Google Scholar]
  56. 56. 
    Men T, Zhang X, Yang J, Shen B, Li X et al. 2014. The rs1050450 C >T polymorphism of GPX1 is associated with the risk of bladder but not prostate cancer: evidence from a meta-analysis. Tumour Biol. 35:269–75
    [Google Scholar]
  57. 57. 
    Moscow JA, Schmidt L, Ingram DT, Gnarra J, Johnson B, Cowan KH 1994. Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. Carcinogenesis 15:2769–73
    [Google Scholar]
  58. 58. 
    Napolioni V, Pariano M, Borghi M, Oikonomou V, Galosi C et al. 2019. Genetic polymorphisms affecting IDO1 or IDO2 activity differently associate with aspergillosis in humans. Front. Immunol. 10:890
    [Google Scholar]
  59. 59. 
    Natl. Heart Lung Blood Inst. (NHLBI) Acute Respirat. Distress Syndr. Clin. Trials Netw., Rice TW, Wheeler AP, Thompson BT, et al. 2012. Initial trophic versus full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 307:795–803
    [Google Scholar]
  60. 60. 
    Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ et al. 2006. Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. Crit. Care 10:R10
    [Google Scholar]
  61. 61. 
    Peake SL, Davies AR, Deane AM, Lange K, Moran JL et al. 2014. Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial. Am. J. Clin. Nutr. 100:616–25
    [Google Scholar]
  62. 62. 
    Peterson SJ, Lateef OB, Freels S, McKeever L, Fantuzzi G, Braunschweig CA. 2018. Early exposure to recommended calorie delivery in the intensive care unit is associated with increased mortality in patients with acute respiratory distress syndrome. J. Parenter. Enteral. Nutr. 42:739–47
    [Google Scholar]
  63. 63. 
    Peterson SJ, McKeever L, Lateef OB, Freels S, Fantuzzi G, Braunschweig CA. 2018. Combination of high-calorie delivery and organ failure increases mortality among patients with acute respiratory distress syndrome. Crit. Care Med. 47:169–75
    [Google Scholar]
  64. 64. 
    Peterson SJ, Tsai AA, Scala CM, Sowa DC, Sheean PM, Braunschweig CL. 2010. Adequacy of oral intake in critically ill patients 1 week after extubation. J. Am. Diet. Assoc. 110:427–33
    [Google Scholar]
  65. 65. 
    Petros S, Horbach M, Seidel F, Weidhase L. 2016. Hypocaloric versus normocaloric nutrition in critically ill patients: a prospective randomized pilot trial. J. Parenter. Enteral. Nutr. 40:242–49
    [Google Scholar]
  66. 66. 
    Reignier J, Boisrame-Helms J, Brisard L, Lascarrou JB, Ait Hssain A et al. 2018. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 391:133–43
    [Google Scholar]
  67. 67. 
    Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP. 2011. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit. Care Med. 39:967–74
    [Google Scholar]
  68. 68. 
    Ridley EJ, Davies AR, Parke R, Bailey M, McArthur C et al. 2018. Supplemental parenteral nutrition versus usual care in critically ill adults: a pilot randomized controlled study. Crit. Care 22:12
    [Google Scholar]
  69. 69. 
    Rubinson L, Diette GB, Song X, Brower RG, Krishnan JA. 2004. Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit. Crit. Care Med. 32:350–57
    [Google Scholar]
  70. 70. 
    Rugeles S, Villarraga-Angulo LG, Ariza-Gutierrez A, Chaverra-Kornerup S, Lasalvia P, Rosselli D. 2016. High-protein hypocaloric versus normocaloric enteral nutrition in critically ill patients: a randomized clinical trial. J. Crit. Care 35:110–14
    [Google Scholar]
  71. 71. 
    Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y. 1996. Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease. Biochem. Biophys. Res. Commun. 226:561–65
    [Google Scholar]
  72. 72. 
    Sim JA, Horowitz M, Summers MJ, Trahair LG, Goud RS et al. 2013. Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years. Intensive Care Med 39:258–66
    [Google Scholar]
  73. 73. 
    Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M et al. 2011. The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med 37:601–9
    [Google Scholar]
  74. 74. 
    TARGET Investig. ANZICS Clin. Trials Group, Chapman M, Peake SL, Bellomo R, Davies A et al. 2018. Energy-dense versus routine enteral nutrition in the critically ill. N. Engl. J. Med 379:1823–34
    [Google Scholar]
  75. 75. 
    Tribl B, Madl C, Mazal PR, Schneider B, Spitzauer S et al. 2000. Exocrine pancreatic function in critically ill patients: septic shock versus non-septic patients. Crit. Care Med. 28:1393–98
    [Google Scholar]
  76. 76. 
    Villet S, Chiolero RL, Bollmann MD, Revelly JP, Cayeux RNM et al. 2005. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin. Nutr. 24:502–9
    [Google Scholar]
  77. 77. 
    Wang S, Ma L, Zhuang Y, Jiang B, Zhang X. 2013. Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition. Crit. Care 17:R171
    [Google Scholar]
  78. 78. 
    Wischmeyer PE, Hasselmann M, Kummerlen C, Kozar R, Kutsogiannis DJ et al. 2017. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit. Care 21:142
    [Google Scholar]
  79. 79. 
    Yeh DD, Cropano C, Quraishi SA, Fuentes E, Kaafarani H et al. 2015. Periprocedural nutrition in the intensive care unit: a pilot study. J. Surg. Res. 198:346–50
    [Google Scholar]
  80. 80. 
    Zauner C, Schuster BI, Schneeweiss B. 2001. Similar metabolic responses to standardized total parenteral nutrition of septic and nonseptic critically ill patients. Am. J. Clin. Nutr. 74:265–70
    [Google Scholar]
  81. 81. 
    Zhu ML, Yu H, Shi TY, He J, Wang MY et al. 2013. Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations. J. Thorac. Oncol. 8:788–95
    [Google Scholar]
  82. 82. 
    Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL. 2006. Intensive care unit length of stay: benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit. Care Med. 34:2517–29
    [Google Scholar]
  83. 83. 
    Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. 2016. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit. Care 20:367
    [Google Scholar]
/content/journals/10.1146/annurev-nutr-111120-114108
Loading
/content/journals/10.1146/annurev-nutr-111120-114108
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error