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Annual Review of Pathology: Mechanisms of Disease

Volume 17, 2022

Infection-Related Myelopathies

Abstract

Recent years have seen growing attention to inflammatory and infectious disorders of the spinal cord, not only due to the discovery of autoantibody-mediated disorders of the spinal cord [e.g., aquaporin-4 immunoglobulin G (IgG) antibodies and myelin oligodendrocyte glycoprotein IgG antibodies], but also due to the emergence of clusters of infection-related myelopathy, now known as acute flaccid myelitis. We review the spectrum of infection-related myelopathies and outline a nosological classification system based on association with infection. We describe the epidemiology and definitions of myelopathies, with a discussion of clinical presentation and neuroimaging features, and then turn to specific discussion of myelopathies due to direct pathogen invasion and those considered to be post- or parainfectious.

Keyword(s): acute flaccid myelitis, epidural abscess, infection, myelitis, myelopathy, transverse myelitis
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2022-01-24
2024-04-20
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/content/journals/10.1146/annurev-pathmechdis-040121-022818
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Infection-Related Myelopathies
Annual Review of Pathology: Mechanisms of Disease 17, 141 (2022); https://doi.org/10.1146/annurev-pathmechdis-040121-022818
/content/journals/10.1146/annurev-pathmechdis-040121-022818
/content/journals/10.1146/annurev-pathmechdis-040121-022818
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