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Annual Review of Physical Chemistry

Volume 71, 2020

Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments

Abstract

Various organic reactions, including important synthetic reactions involving C–C, C–N, and C–O bond formation as well as reactions of biomolecules, are accelerated when the reagents are present in sprayed or levitated microdroplets or in thin films. The reaction rates increase by orders of magnitude with decreasing droplet size or film thickness. The effect is associated with reactions at the solution–air interface. A key factor is partial solvation of the reagents at the interface, which reduces the critical energy for reaction. This phenomenon is of intrinsic interest and potentially of practical value as a simple, rapid method of performing small-scale synthesis.

Keyword(s): electrospray ionization, interfacial reactions, ion solvation, mass spectrometry, reaction acceleration
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/content/journals/10.1146/annurev-physchem-121319-110654
2020-04-20
2024-04-16
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Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments
Annual Review of Physical Chemistry 71, 31 (2020); https://doi.org/10.1146/annurev-physchem-121319-110654
/content/journals/10.1146/annurev-physchem-121319-110654
/content/journals/10.1146/annurev-physchem-121319-110654
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  • Article Type: Review Article

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