1932

Abstract

Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, , have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in , providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this “simple” model organism.

[Erratum, Closure]

An erratum has been published for this article:
Circadian Organization of Behavior and Physiology in
Loading

Article metrics loading...

/content/journals/10.1146/annurev-physiol-021909-135815
2010-03-17
2024-03-29
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-physiol-021909-135815
Loading
/content/journals/10.1146/annurev-physiol-021909-135815
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error