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Annual Review of Physiology

Volume 77, 2015

Hedgehog Signaling and Steroidogenesis

Abstract

Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta. New evidence links the evolutionarily conserved Hh pathway to the steroidogenic organs, demonstrating how Hh signaling can influence their development and homeostasis and can act in concert with steroids to mediate physiological functions. In this review, we highlight the role of the components of the Hh signaling pathway in steroidogenesis of endocrine tissues.

Keyword(s): adrenal, ovary, placenta, Sf1, steroids, testis
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/content/journals/10.1146/annurev-physiol-061214-111754
2015-02-10
2024-04-24
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Hedgehog Signaling and Steroidogenesis
Annual Review of Physiology 77, 105 (2015); https://doi.org/10.1146/annurev-physiol-061214-111754
/content/journals/10.1146/annurev-physiol-061214-111754
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