1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Biochemistry
  4. Volume 67, 1998
  5. Article

Annual Review of Biochemistry

Volume 67, 1998

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Abstract

Mammalian AMP-activated protein kinase and yeast SNF1 protein kinase are the central components of kinase cascades that are highly conserved between animals, fungi, and plants. The AMP-activated protein kinase cascade acts as a metabolic sensor or “fuel gauge” that monitors cellular AMP and ATP levels because it is activated by increases in the AMP:ATP ratio. Once activated, the enzyme switches off ATP-consuming anabolic pathways and switches on ATP-producing catabolic pathways, such as fatty acid oxidation. The SNF1 complex in yeast is activated in response to the stress of glucose deprivation. In this case the intracellular signal or signals have not been identified; however, SNF1 activation is associated with depletion of ATP and elevation of AMP. The SNF1 complex acts primarily by inducing expression of genes required for catabolic pathways that generate glucose, probably by triggering phosphorylation of transcription factors. SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.

Keyword(s): ATP depletion, cellular stress, gene expression, glucose repression, protein phosphorylation
Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.67.1.821
1998-07-01
2024-04-16
Loading full text...

Full text loading...

/deliver/fulltext/biochem/67/1/annurev.biochem.67.1.821.html?itemId=/content/journals/10.1146/annurev.biochem.67.1.821&mimeType=html&fmt=ahah

Literature Cited

  1. Beg ZH, Allmann DW, Gibson DM. 1973. Biochem. Biophys. Res. Commun. 54:1362–69
  2. Carlson CA, Kim KH. 1973. J. Biol. Chem. 248:378–80
  3. Carling D, Zammit VA, Hardie DG. 1987. FEBS Lett. 223:217–22
  4. Hardie DG, Carling D, Sim ATR. 1989. Trends Biochem. Sci. 14:20–23
  5. Brown MS, Brunschede GY, Goldstein JL. 1975. J. Biol. Chem. 250:2502–9
  6. Keith ML, Rodwell VW, Rogers DH, Rudney H. 1979. Biochem. Biophys. Res. Commun. 90:969–75
  7. Beg ZH, Stonik JA, Brewer HB. 1978. Proc. Natl. Acad. Sci. USA 75:3678–82
  8. Yeh LA, Lee KH, Kim KH. 1980. J. Biol. Chem. 255:2308–14
  9. Ferrer A, Caelles C, Massot N, Hegardt FG. 1985. Biochem. Biophys. Res. Commun. 132:497–504
  10. Carling D, Clarke PR, Zammit VA, Hardie DG. 1989. Eur. J. Biochem. 186:129–36
  11. Zimmermann FK, Kaufmann I, Rasenberger H, Haussman P. 1977. Mol. Gen. Genet. 1951:95–103
  12. Ciriacy M. 1977. Mol. Gen. Genet. 154:213–20
  13. Carlson M, Osmond BC, Botstein D. 1981. Genetics 98:25–40
  14. Johnston M, Carlson M. 1992. In The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression 2193–281
  15. Simon M, Binder M, Adam G, Hartig A, Ruis H. 1992. Yeast 8:303–9
  16. Thompson-Jaeger S, Francois J, Gaughran JP, Tatchell K. 1991. Genetics 129:697–706
  17. Hubbard EJA, Yang XL, Carlson M. 1992. Genetics 130:71–80
  18. Hardy TA, Huang D, Roach PJ. 1994. J. Biol. Chem. 269:27907–13
  19. Entian KD, Zimmermann FK. 1982. J. Bacteriol. 151:1123–28
  20. Neigeborn L, Carlson M. 1984. Genetics 108:845–58
  21. Beg ZH, Stonik JA, Brewer HB. 1979. Proc. Natl. Acad. Sci. USA 76:4375–79
  22. Shiao M, Drong RF, Porter JW. 1981. Biochem. Biophys. Res. Commun. 98:80–87
  23. Lent B, Kim KH. 1982. J. Biol. Chem. 257:1897–901
  24. Ferrer A, Caelles C, Massot N, Hegardt FG. 1987. J. Biol. Chem. 262:13507–12
  25. Davies SP, Hawley SA, Woods A, Carling D, Haystead TAJ, Hardie DG. 1994. Eur. J. Biochem. 223:351–57
  26. Mitchelhill KI, Stapleton D, Gao G, House C, Michell B. et al. 1994. J. Biol. Chem. 269:2361–64
  27. Michell BJ, Stapleton D, Mitchelhill KI, House CM, Katsis F. et al. 1996. J. Biol. Chem. 271:28445–50
  28. Carling D, Aguan K, Woods A, Verhoeven AJM, Beri RK. et al. 1994. J. Biol. Chem. 269:11442–48
  29. Gao G, Widmer J, Stapleton D, Teh T, Cox T. et al. 1995. Biochim. Biophys. Acta 1266:73–82
  30. Stapleton D, Gao G, Michell BJ, Widmer J, Mitchelhill K. et al. 1994. J. Biol. Chem. 269:29343–46
  31. Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J. et al. 1996. J. Biol. Chem. 271:8675–81
  32. Woods A, Cheung PCF, Smith FC, Davison MD, Scott J. et al. 1996. J. Biol. Chem. 271:10282–90
  33. Dyck JRB, Gao G, Widmer J, Stapleton D, Fernandez CS. et al. 1996. J. Biol. Chem. 271:17798–803
  34. Woods A, Salt I, Scott J, Hardie DG, Carling D. 1996. FEBS Lett. 397:347–51
  35. Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ. et al. 1996. J. Biol. Chem. 271:611–14
  36. Thornton C, Snowden MA, Carling D. 1998. J. Biol. Chem. In press
  37. Bateman A. 1997. Trends Biochem. Sci. 22:12–13
  38. Kluijtmans LA, Boers GH, Stevens EM, Renier WO, Kraus JP. et al. 1996. J. Clin. Invest. 98:285–89
  39. Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP. et al. 1996. Cell 85:921–30
  40. Celenza JL, Carlson M. 1986. Science 233:1175–80
  41. Schuller HJ, Entian KD. 1987. Mol. Gen. Genet. 209:366–73
  42. Schuller HJ, Entian KD. 1988. Gene 67:247–57
  43. Celenza JL, Eng FJ, Carlson M. 1989. Mol. Cell. Biol. 9:5045–54
  44. Celenza JL, Carlson M. 1989. Mol. Cell. Biol. 9:5034–44
  45. Wilson WA, Hawley SA, Hardie DG. 1996. Curr. Biol. 6:1426–34
  46. Jiang R, Carlson M. 1997. Mol. Cell. Biol. 17:2099–106
  47. Estruch F, Treitel MA, Yang XL, Carlson M. 1992. Genetics 132:639–50
  48. Fields S, Song OK. 1989. Nature 340:245–46
  49. Woods A, Munday MR, Scott J, Yang XL, Carlson M, Carling D. 1994. J. Biol. Chem. 269:19509–15
  50. Yang X, Hubbard EJA, Carlson M. 1992. Science 257:680–82
  51. Yang X, Jiang R, Carlson M. 1994. EMBO J. 13:5878–86
  52. Matsumoto K, Toh-e A, Oshima Y. 1981. Mol. Cell. Biol. 1:83–93
  53. Erickson JR, Johnston M. 1993. Genetics 135:655–64
  54. Goffrini P, Ficarelli A, Donnini C, Lodi T, Puglisi PP, Ferrero I. 1996. Curr. Genet. 29:316–26
  55. Alderson A, Sabelli PA, Dickinson JR, Cole D, Richardson M. et al. 1991. Proc. Natl. Acad. Sci. USA 88:8602–5
  56. LeGuen L, Thomas M, Bianchi M, Halford NG, Kreis M. 1992. Gene 120:249–54
  57. Hannappel U, Vicente-Carbajosa J, Barker JHA, Shewry PR, Halford NG. 1995. Plant Mol. Biol. 27:1235–40
  58. Halford NG, Vicente-Carbajosa J, Sabelli PA, Shewry PR, Hannappel U, Kreis M. 1992. Plant J. 2:791–97
  59. Muranaka T, Banno H, Machida Y. 1994. Mol. Cell. Biol. 14:2958–65
  60. MacKintosh RW, Davies SP, Clarke PR, Weekes J, Gillespie JG. et al. 1992. Eur. J. Biochem. 209:923–31
  61. Davies SP, Carling D, Hardie DG. 1989. Eur. J. Biochem. 186:123–28
  62. Ball KL, Dale S, Weekes J, Hardie DG. 1994. Eur. J. Biochem. 219:743–50
  63. Dale S, Wilson WA, Edelman AM, Hardie DG. 1995. FEBS Lett. 361:191–95
  64. Ball KL, Barker J, Halford NG, Hardie DG. 1995. FEBS Lett. 377:189–92
  65. Jiang R, Carlson M. 1996. Genes Dev. 10:3105–15
  66. Ingebritsen TS, Lee H, Parker RA, Gibson DM. 1978. Biochem. Biophys. Res. Commun. 81:1268–77
  67. Ingebritsen TS, Parker RA, Gibson DM. 1981. J. Biol. Chem. 256:1138–44
  68. Moore F, Weekes J, Hardie DG. 1991. Eur. J. Biochem. 199:691–97
  69. Weekes J, Hawley SA, Corton J, Shugar D, Hardie DG. 1994. Eur. J. Biochem. 219:751–57
  70. Clarke PR, Moore F, Hardie DG. 1991. Adv. Protein Phosphatases 6:187–209
  71. Davies SP, Helps NR, Cohen PTW, Hardie DG. 1995. FEBS Lett. 377:421–25
  72. Monod J, Wyman J, Changeux JP. 1965. J. Mol. Biol. 12:88–118
  73. Hawley SA, Davison M, Woods A, Davies SP, Beri RK. et al. 1996. J. Biol. Chem. 271:27879–87
  74. Corton JM, Gillespie JG, Hawley SA, Hardie DG. 1995. Eur. J. Biochem. 229:558–65
  75. Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 1995. J. Biol. Chem. 270:27186–91
  76. Johnson LN, Noble MEM, Owen DJ. 1996. Cell 85:149–58
  77. Hardie DG, Carling D. 1997. Eur. J. Biochem. 246:259–73
  78. Corton JM, Gillespie JG, Hardie DG. 1994. Curr. Biol. 4:315–24
  79. Sato R, Goldstein JL, Brown MS. 1993. Proc. Natl. Acad. Sci. USA 90:9261–65
  80. Witters LA, Nordlund AC, Marshall L. 1991. Biochem. Biophys. Res. Commun. 181:1486–92
  81. Ritossa FM. 1964. Exp. Cell Res. 35:601–7
  82. Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD. 1995. J. Biol. Chem. 270:17513–20
  83. Kudo N, Gillespie JG, Kung L, Witters LA, Schulz R. et al. 1996. Biochim. Biophys. Acta 1301:67–75
  84. Winder WW, Hardie DG. 1996. Am. J. Physiol. 270:E299–304
  85. Hutber CA, Hardie DG, Winder WW. 1997. Am. J. Physiol. 272:E262–66
  86. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A. et al. 1997. J. Biol. Chem. 272:13255–61
  87. Arebalo RE, Hardgrave JE, Scallen TJ. 1981. J. Biol. Chem. 256:571–74
  88. Arebalo RE, Hardgrave JE, Noland BJ, Scallen TJ. 1980. Proc. Natl. Acad. Sci. USA 77:6429–33
  89. Beg ZH, Reznikov DC, Avigan J. 1986. Arch. Biochem. Biophys. 244:310–22
  90. Munday MR, Milic MR, Takhar S, Holness MJ, Sugden MC. 1991. Biochem. J. 280:733–37
  91. Witters LA, Kemp BE. 1992. J. Biol. Chem. 267:2864–67
  92. Davies SP, Carling D, Munday MR, Hardie DG. 1992. Eur. J. Biochem. 203:615–23
  93. Neigeborn L, Carlson M. 1987. Genetics 115:247–53
  94. Stark MJ. 1996. Yeast 12:1647–75
  95. Tu JL, Carlson M. 1995. EMBO J. 14:5939–46
  96. Tu JL, Carlson M. 1994. Mol. Cell. Biol. 14:6789–96
  97. Weekes J, Ball KL, Caudwell FB, Hardie DG. 1993. FEBS Lett. 334:335–39
  98. Ching YP, Davies SP, Hardie DG. 1996. Eur. J. Biochem. 237:800–8
  99. Clarke PR, Hardie DG. 1990. EMBO J. 9:2439–46
  100. Gillespie JG, Hardie DG. 1992. FEBS Lett. 306:59–62
  101. Henin N, Vincent MF, Gruber HE, Van den Berghe G. 1995. FASEB J. 9:541–46
  102. Munday MR, Campbell DG, Carling D, Hardie DG. 1988. Eur. J. Biochem. 175:331–38
  103. Davies SP, Sim ATR, Hardie DG. 1990. Eur. J. Biochem. 187:183–90
  104. Lopez-Casillas F, Bai DH, Luo XC, Kong IS, Hermodson MA, Kim KH. 1988. Proc. Natl. Acad. Sci. USA 85:5784–88
  105. Ha J, Daniel S, Broyles SS, Kim KH. 1994. J. Biol. Chem. 269:22162–68
  106. McGarry JD, Takabayashi Y, Foster DW. 1978. J. Biol. Chem. 253:8294–300
  107. Weis BC, Cowan AT, Brown N, Foster DW, McGarry JD. 1994. J. Biol. Chem. 269:26443–48
  108. Abu Elheiga L, Almarza Ortega DB, Baldini A, Wakil SJ. 1997. J. Biol. Chem. 272:10669–77
  109. Ha J, Lee JK, Kim KS, Witters LA, Kim KH. 1996. Proc. Natl. Acad. Sci. USA 93:11466–70
  110. Winder WW, Wilson HA, Hardie DG, Rasmussen BB, Hutber CA. et al. 1997. J. Appl. Physiol. 82:219–25
  111. Merrill GM, Kurth E, Hardie DG, Winder WW. 1997. Am. J. Physiol. 36:E1107–12
  112. Velasco G, Geelen MJH, Guzman M. 1997. Arch. Biochem. Biophys. 337:169–75
  113. Garton AJ, Campbell DG, Cohen P, Yeaman SJ. 1988. FEBS Lett. 229:68–72
  114. Yeaman SJ. 1990. Biochim. Biophys. Acta 1052:128–32
  115. Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. 1989. Eur. J. Biochem. 179:249–54
  116. Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. 1994. FEBS Lett. 353:33–36
  117. Brooks BJ, Arch JR, Newsholme EA. 1983. Biosci. Rep. 3:263–67
  118. Brown MS, Ho YK, Goldstein JL. 1980. J. Biol. Chem. 255:9344–52
  119. Carling D, Hardie DG. 1989. Biochim. Biophys. Acta 1012:81–86
  120. Flotow H, Roach PJ. 1989. J. Biol. Chem. 264:9126–28
  121. Morrison DK, Cutler RE. 1997. Curr. Opin. Cell Biol. 9:174–79
  122. Morrison DK, Heidecker G, Rapp UR, Copeland TD. 1993. J. Biol. Chem. 268:17309–16
  123. Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW. 1997. FEBS Lett. 403:254–58
  124. Mischak H, Seitz T, Janosch P, Eulitz M, Steen H. et al. 1996. Mol. Cell. Biol. 16:5409–18
  125. Nehlin JO, Ronne H. 1990. EMBO J. 9:2891–98
  126. Nehlin JO, Carlberg M, Ronne H. 1991. EMBO J. 10:3373–77
  127. Johnston M, Flick JS, Pexton T. 1994. Mol. Cell. Biol. 14:3834–41
  128. Vallier LG, Carlson M. 1994. Genetics 137:49–54
  129. Keleher CA, Redd MJ, Schultz J, Carlson M, Johnson AD. 1992. Cell 68:709–19
  130. Tzamarias D, Struhl K. 1994. Nature 369:758–61
  131. Treitel MA, Carlson M. 1995. Proc. Natl. Acad. Sci. USA 92:3132–36
  132. Tzamarias D, Struhl K. 1995. Genes Dev. 9:821–31
  133. DeVit MJ, Waddle JA, Johnston M. 1997. Mol. Biol. Cell 8:1603–18
  134. Ostling J, Carlberg M, Ronne H. 1996. Mol. Cell. Biol. 16:753–61
  135. Lesage P, Yang XL, Carlson M. 1994. Nucleic Acids Res. 22:597–603
  136. Lesage P, Yang XL, Carlson M. 1996. Mol. Cell. Biol. 16:1921–28
  137. Hedges D, Proft M, Entian KD. 1995. Mol. Cell. Biol. 15:1915–22
  138. Randez-Gil F, Bojunga N, Proft M, Entian KD. 1997. Mol. Cell. Biol. 17:2502–10
  139. Dale S, Arró M, Becerra B, Morrice NG, Boronat A. et al. 1995. Eur. J. Biochem. 233:506–13
  140. Chappell J, Wolf F, Proulx J, Cuellar R, Saunders C. 1995. Plant Physiol. 109:1337
  141. McMichael RW Jr, Klein RR, Salvucci ME, Huber SC. 1993. Arch. Biochem. Biophys. 307:248–52
  142. Douglas P, Morrice N, MacKintosh C. 1995. FEBS Lett. 377:113–17
  143. Bachmann M, Shiraishi N, Campbell WH, Yoo BC, Harmon AC, Huber SC. 1996. Plant Cell 8:505–17
  144. Huber SC, Huber JL. 1996. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47:431–44
  145. Moorhead G, Douglas P, Morrice N, Scarabel M, Aitken A, MacKintosh C. 1996. Curr. Biol. 6:1104–13
  146. Bachmann M, Huber JL, Liao PC, Gage DA, Huber SC. 1996. FEBS Lett. 387:127–31
  147. McMichael RW Jr, Bachmann M, Huber SC. 1995. Plant Physiol. 108:1077–82
  148. Douglas P, Pigaglio E, MacKintosh C. 1997. Biochem. J. In press
  149. Jang JC, Sheen J. 1994. Plant Cell 6:1665–79
  150. Grahame IA, Denby KJ, Leaver CJ. 1994. Plant Cell 6:761–72
  151. Hardie DG, Hanks SK. 1995. The Protein Kinase Factsbook: Protein-Serine Kinases. London: Academic 418 pp.
  152. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N. et al. 1996. EMBO J. 15:6541–51
/content/journals/10.1146/annurev.biochem.67.1.821
Loading
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
Annual Review of Biochemistry 67, 821 (1998); https://doi.org/10.1146/annurev.biochem.67.1.821
/content/journals/10.1146/annurev.biochem.67.1.821
/content/journals/10.1146/annurev.biochem.67.1.821
Loading

Data & Media loading...

  • Article Type: Introduction

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error