1932

Abstract

Double-strand breaks and other lesions in DNA can stimulate homologous genetic recombination in two quite different ways: by promoting recombination near the break (roughly within a kb) or far from the break. Recent emphasis on the repair aspect of recombination has focused attention on DNA interactions and recombination near breaks. Here I review evidence for recombination far from DNA breaks in bacteria and fungi and discuss mechanisms by which this can occur. These mechanisms include entry of a traveling entity (“recombination machine”) at a break, formation of long heteroduplex DNA, priming of DNA replication by a broken end, and induction of recombination potential in . Special emphasis is placed on contrasting views of how the RecBCD enzyme of promotes recombination far (tens of kb) from a double-strand break. The occurrence of recombination far from DNA breaks and of correlated recombination events far apart suggests that “action at a distance” during recombination is a widespread feature among diverse organisms.

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/content/journals/10.1146/annurev.genet.35.102401.090509
2001-12-01
2024-03-28
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  • Article Type: Review Article
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