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Annual Review of Biochemistry

Volume 83, 2014

Metabolic and Nontranscriptional Circadian Clocks: Eukaryotes

Abstract

Circadian clocks are cellular timekeeping mechanisms that coordinate behavior and physiology around the 24-h day in most living organisms. Misalignment of an organism's clock with its environment is associated with long-term adverse fitness consequences, as exemplified by the link between circadian disruption and various age-related diseases in humans. Current eukaryotic models of the circadian oscillator rely on transcription/translation feedback loop mechanisms, supplemented with accessory cytosolic loops that connect them to cellular physiology. However, mounting evidence is questioning the absolute necessity of transcription-based oscillators for circadian rhythmicity, supported by the recent discovery of oxidation-reduction cycles of peroxiredoxin proteins, which persist even in the absence of transcription. A more fundamental mechanism based on metabolic cycles could thus underlie circadian transcriptional and cytosolic rhythms, thereby promoting circadian oscillations to integral properties of cellular metabolism.

Keyword(s): oscillator, oxidation-reduction, peroxiredoxin, posttranscriptional, posttranslational, redox
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2014-06-02
2024-04-24
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Metabolic and Nontranscriptional Circadian Clocks: Eukaryotes
Annual Review of Biochemistry 83, 165 (2014); https://doi.org/10.1146/annurev-biochem-060713-035623
/content/journals/10.1146/annurev-biochem-060713-035623
/content/journals/10.1146/annurev-biochem-060713-035623
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