1932

Abstract

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. We propose a model of estrogen effects on multiple brain systems that interface with stress-related emotional and cognitive processes implicated in MDD and discuss possible mechanisms through which reproductive events and changes in estrogen may contribute to MDD risk in women with other concurrent risk factors.

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2019-05-07
2024-03-28
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Literature Cited

  1. Albert K, Gau V, Taylor WD, Newhouse PA 2017. Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity. J. Affect. Disord. 210:49–56
    [Google Scholar]
  2. Albert K, Pruessner J, Newhouse P 2015. Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle. Psychoneuroendocrinology 59:14–24
    [Google Scholar]
  3. Altemus M 2006. Sex differences in depression and anxiety disorders: potential biological determinants. Horm. Behav. 50:4534–38
    [Google Scholar]
  4. Archer DF, Sturdee DW, Baber R, De Villiers TJ, Pines A et al. 2011. Menopausal hot flushes and night sweats: Where are we now. ? Climacteric 14:515–28
    [Google Scholar]
  5. Arnone D, McKie S, Elliott R, Thomas EJ, Downey D et al. 2012. Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. Am. J. Psychiatry 169:8841–50
    [Google Scholar]
  6. Arnsten AFT 2009. Stress signalling pathways that impair prefrontal cortex structure and function. Nat. Rev. Neurosci. 10:410–22
    [Google Scholar]
  7. Berman KF, Schmidt PJ, Rubinow DR, Danaceau MA, Van Horn JD et al. 1997. Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. PNAS 94:168836–41
    [Google Scholar]
  8. Bishop SJ 2004. State anxiety modulation of the amygdala response to unattended threat-related stimuli. J. Neurosci. 24:4610364–68
    [Google Scholar]
  9. Booij L, Van der Does W, Benkelfat C, Bremner JD, Cowen PJ et al. 2002. Predictors of mood response to acute tryptophan depletion: a reanalysis. Neuropsychopharmacology 27:852–61
    [Google Scholar]
  10. Bove R, Secor E, Chibnik LB, Barnes LL, Schneider JA et al. 2014. Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women. Neurology 82:3222–29
    [Google Scholar]
  11. Bryant RA, Felmingham KL, Silove D, Creamer M, O'Donnell M, McFarlane AC 2011. The association between menstrual cycle and traumatic memories. J. Affect. Disord. 131:398–401
    [Google Scholar]
  12. Burke HM, Fernald LC, Gertler PJ, Adler NE 2005. Depressive symptoms are associated with blunted cortisol stress responses in very low-income women. Psychosom. Med. 67:2211–16
    [Google Scholar]
  13. Canli T, Desmond JE, Zhao Z, Gabrieli JD 2002. Sex differences in the neural basis of emotional memories. PNAS 99:1610789–94
    [Google Scholar]
  14. Carney RM, Freedland KE 2003. Depression, mortality, and medical morbidity in patients with coronary heart disease. Biol. Psychiatry 54:241–47
    [Google Scholar]
  15. Chen P, Kales HC, Weintraub D, Blow FC, Jiang L, Mellow AM 2007. Antidepressant treatment of veterans with Parkinson's disease and depression: analysis of a national sample. J. Geriatr. Psychiatry Neurol. 20:3161–65
    [Google Scholar]
  16. Chun MM, Turk-Browne NB 2007. Interactions between attention and memory. Curr. Opin. Neurobiol. 17:177–84
    [Google Scholar]
  17. Cornwell BR, Alvarez RP, Lissek S, Kaplan R, Ernst M, Grillon C 2011. Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors. Neuropsychologia 49:51363–68
    [Google Scholar]
  18. Craig MC, Murphy DG 2007. Estrogen: effects on normal brain function and neuropsychiatric disorders. Climacteric 10:97–104
    [Google Scholar]
  19. De Raedt R, Koster EHW 2010. Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework. Cogn. Affect. Behav. Neurosci. 10:150–70
    [Google Scholar]
  20. Dent J, Teasdale JD 1988. Negative cognition and the persistence of depression. J. Abnorm. Psychol. 97:129–34
    [Google Scholar]
  21. Derijk R, Sternberg EM 1994. Corticosteroid action and neuroendocrine–immune interactions. Ann. N. Y. Acad. Sci. 746:33–41
    [Google Scholar]
  22. Derntl B, Windischberger C, Robinson S, Lamplmayr E, Kryspin-Exner I et al. 2008. Facial emotion recognition and amygdala activation are associated with menstrual cycle phase. Psychoneuroendocrinology 33:81031–40
    [Google Scholar]
  23. Disner SG, Beevers CG, Haigh EAP, Beck AT 2011. Neural mechanisms of the cognitive model of depression. Nat. Rev. Neurosci. 12:467–77
    [Google Scholar]
  24. Drevets WC 2000. Neuroimaging studies of mood disorders. Biol. Psychiatry 48:8813–29
    [Google Scholar]
  25. Drevets WC, Price JL, Furey ML 2008. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct. Funct. 213:1–293–118
    [Google Scholar]
  26. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T et al. 1997. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824–27
    [Google Scholar]
  27. Duman RS, Li N 2012. A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists. Philos. Trans. R. Soc. B 367:16012475–84
    [Google Scholar]
  28. Dumas JA, Kutz AM, Naylor MR, Johnson JV, Newhouse PA 2012. Estradiol treatment altered anticholinergic-related brain activation during working memory in postmenopausal women. NeuroImage 60:21394–403
    [Google Scholar]
  29. Egeth HE, Yantis S 1997. Visual attention: control, representation, and time course. Annu. Rev. Psychol. 48:269–97
    [Google Scholar]
  30. Epperson CN, Sammel MD, Freeman EW 2013. Menopause effects on verbal memory: findings from a longitudinal community cohort. J. Clin. Endocrinol. Metab. 98:93829–38
    [Google Scholar]
  31. Erk S, Mikschl A, Stier S, Ciaramidaro A, Gapp V et al. 2010. Acute and sustained effects of cognitive emotion regulation in major depression. J. Neurosci. 30:4715726–34
    [Google Scholar]
  32. Ertman N, Andreano JM, Cahill L 2012. Progesterone at encoding predicts subsequent emotional memory. Learn. Mem. 18:759–63
    [Google Scholar]
  33. Feldman S, Weidenfeld J 1999. Glucocorticoid receptor antagonists in the hippocampus modify the negative feedback following neural stimuli. Brain Res 821:133–37
    [Google Scholar]
  34. Ferree NK, Kamat R, Cahill L 2011. Influences of menstrual cycle position and sex hormone levels on spontaneous intrusive recollections following emotional stimuli. Conscious. Cogn. 20:1154–62
    [Google Scholar]
  35. Fink G, Sumner BEH, Rosie R, Grace O, Quinn JP 1996. Estrogen control of central neurotransmission: effect on mood, mental state, and memory. Cell. Mol. Neurobiol. 16:3325–44
    [Google Scholar]
  36. Freeman EW, Sammel MD, Boorman DW, Zhang R 2014. Longitudinal pattern of depressive symptoms around natural menopause. JAMA Psychiatry 71:136–43
    [Google Scholar]
  37. Frey BN, Hall GB, Attard S, Yucel K, Skelin I et al. 2010. Shift in the brain network of emotional regulation in midlife women: Is the menopausal transition the turning point. ? Menopause 17:4840–45
    [Google Scholar]
  38. Gaddy MA, Ingram RE 2014. A meta-analytic review of mood-congruent implicit memory in depressed mood. Clin. Psychol. Rev. 34:402–16
    [Google Scholar]
  39. Gibbs RB 2010. Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr. Rev. 31:224–53
    [Google Scholar]
  40. Gillies GE, McArthur S 2010. Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol. Rev. 62:2155–98
    [Google Scholar]
  41. Gold PW 2015. The organization of the stress system and its dysregulation in depressive illness. Mol. Psychiatry 20:32–47
    [Google Scholar]
  42. Goldstein JM 2005. Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J. Neurosci. 25:409309–16
    [Google Scholar]
  43. Gonda X, Telek T, Juhász G, Lazary J, Vargha A, Bagdy G 2008. Patterns of mood changes throughout the reproductive cycle in healthy women without premenstrual dysphoric disorders. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 32:81782–88
    [Google Scholar]
  44. Gotlib IH, Joormann J 2010. Cognition and depression: current status and future directions. Annu. Rev. Clin. Psychol. 6:285–312
    [Google Scholar]
  45. Halbreich U, Lumley LA, Palter S, Manning C, Gengo F, Joe SH 1995a. Possible acceleration of age effects on cognition following menopause. J. Psychiatr. Res. 29:3153–63
    [Google Scholar]
  46. Halbreich U, Rojansky N, Palter S, Tworek H, Hissin P, Wang K 1995b. Estrogen augments serotonergic activity in postmenopausal women. Biol. Psychiatry 37:7434–41
    [Google Scholar]
  47. Hall GBC, Witelson SF, Szechtman H, Nahmias C 2004. Sex differences in functional activation patterns revealed by increased emotion processing demands. NeuroReport 15:2219–23
    [Google Scholar]
  48. Hallion LS, Ruscio AM 2011. A meta-analysis of the effect of cognitive bias modification on anxiety and depression. Psychol. Bull. 137:6940–58
    [Google Scholar]
  49. Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT et al. 2006. Brain connectivity related to working memory performance. J. Neurosci. 26:5113338–43
    [Google Scholar]
  50. Hankin BL, Mermelstein R, Roesch L 2007. Sex differences in adolescent depression: stress exposure and reactivity models. Child Dev 78:1279–95
    [Google Scholar]
  51. Herman JP, Cullinan WE 1997. Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis. Trends Neurosci 20:78–84
    [Google Scholar]
  52. Hogervorst E, Bandelow S 2010. Sex steroids to maintain cognitive function in women after the menopause: a meta-analyses of treatment trials. Maturitas 66:56–71
    [Google Scholar]
  53. Holsboer F, Von Bardeleben U, Gerken A, Stalla GK, Müller OA 1984. Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N. Engl. J. Med. 311:1127
    [Google Scholar]
  54. Isaac L, Vrijsen JN, Rinck M, Speckens A, Becker ES 2014. Shorter gaze duration for happy faces in current but not remitted depression: evidence from eye movements. Psychiatry Res 218:1–279–86
    [Google Scholar]
  55. Jaako-Movits K, Zharkovsky T, Pedersen M, Zharkovsky A 2006. Decreased hippocampal neurogenesis following olfactory bulbectomy is reversed by repeated citalopram administration. Cell. Mol. Neurobiol. 26:7–81559–70
    [Google Scholar]
  56. Jankord R, Herman JP 2008. Limbic regulation of hypothalamo–pituitary–adrenocortical function during acute and chronic stress. Ann. N. Y. Acad. Sci. 1148:64–73
    [Google Scholar]
  57. Jessen F, Amariglio RE, Van Boxtel M, Breteler M, Ceccaldi M et al. 2014. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's Dement 10:844–52
    [Google Scholar]
  58. Jiang W, Krishnan RR, O'Connor CM 2002. Depression and heart disease: evidence of a link, and its therapeutic implications. CNS Drugs 16:2111–27
    [Google Scholar]
  59. Joynt KE, Whellan DJ, O'Connor CM 2003. Depression and cardiovascular disease: mechanisms of interaction. Biol. Psychiatry 54:248–261
    [Google Scholar]
  60. Kelly MJ, Levin ER 2001. Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab. 12:152–56
    [Google Scholar]
  61. Kendler KS, Thornton LM, Gardner CO 2000. Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am. J. Psychiatry 157:81243–51
    [Google Scholar]
  62. Kessler RC 2003. Epidemiology of women and depression. J. Affect. Disord. 74:15–13
    [Google Scholar]
  63. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE 2005. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62:6593–602
    [Google Scholar]
  64. Kim JJ, Diamond DM 2002. The stressed hippocampus, synaptic plasticity and lost memories. Nat. Rev. Neurosci. 3:6453–62
    [Google Scholar]
  65. Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH 1999. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus–pituitary–adrenal axis. Psychosom. Med. 61:2154–62
    [Google Scholar]
  66. Kret ME, De Gelder B 2012. A review on sex differences in processing emotional signals. Neuropsychologia 50:1211–21
    [Google Scholar]
  67. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C 2004. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 29:183–98
    [Google Scholar]
  68. Kugaya A, Epperson CN, Zoghbi S, van Dyck CH, Hou Y et al. 2003. Increase in prefrontal cortex serotonin2A receptors following estrogen treatment in postmenopausal women. Am. J. Psychiatry 160:81522–24
    [Google Scholar]
  69. Lethaby A, Hogervorst E, Richards M, Yesufu A, Yaffe K 2008. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst. Rev. 1:CD003122
    [Google Scholar]
  70. Liu RT, Alloy LB 2010. Stress generation in depression: a systematic review of the empirical literature and recommendations for future study. Clin. Psychol. Rev. 30:582–93
    [Google Scholar]
  71. Luine V 2014. Estradiol and cognitive function: past, present and future. Horm. Behav. 66:4602–18
    [Google Scholar]
  72. Lupien SJ, Fiocco A, Wan N, Maheu F, Lord C et al. 2005. Stress hormones and human memory function across the lifespan. Psychoneuroendocrinology 30:3225–42
    [Google Scholar]
  73. Lupien SJ, McEwen BS, Gunnar MR, Heim C 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10:434–45
    [Google Scholar]
  74. Magariños AM, McEwen BS 1995. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: comparison of stressors. Neuroscience 69:183–88
    [Google Scholar]
  75. Maki PM, Dumas J 2009. Mechanisms of action of estrogen in the brain: insights from human neuroimaging and psychopharmacologic studies. Semin. Reprod. Med. 27:250–59
    [Google Scholar]
  76. Maki PM, Gast MJ, Vieweg AJ, Burriss SW, Yaffe K 2007. Hormone therapy in menopausal women with cognitive complaints: a randomized, double-blind trial. Neurology 69:131322–30
    [Google Scholar]
  77. Mayberg HS 1997. Limbic–cortical dysregulation: a proposed model of depression. J. Neuropsychiatry Clin. Neurosci. 9:3471–81
    [Google Scholar]
  78. McEwen BS 2002. Estrogen actions throughout the brain. Recent Prog. Horm. Res. 57:357–84
    [Google Scholar]
  79. McEwen BS, Akama KT, Spencer-Segal JL, Milner TA, Waters EM 2012. Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms. Behav. Neurosci. 126:14–16
    [Google Scholar]
  80. McGaugh JL 2004. The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu. Rev. Neurosci. 27:1–28
    [Google Scholar]
  81. McKinnon MC, Yucel K, Nazarov A, MacQueen GM 2009. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J. Psychiatry Neurosci. 34:141–54
    [Google Scholar]
  82. Miller GE, Stetler CA, Carney RM, Freedland KE, Banks WA 2002. Clinical depression and inflammatory risk markers for coronary heart disease. Am. J. Cardiol. 90:121279–83
    [Google Scholar]
  83. Ming GL, Song H 2011. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687–702
    [Google Scholar]
  84. Mohanty A, Sussman TJ 2013. Top-down modulation of attention by emotion. Front. Hum. Neurosci. 7:102
    [Google Scholar]
  85. Moreno FA, McGahuey CA, Freeman MP, Delgado PL 2006. Sex differences in depressive response during monoamine depletions in remitted depressive subjects. J. Clin. Psychiatry 67:1618–23
    [Google Scholar]
  86. Moulton CD, Pickup JC, Ismail K 2015. The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol 3:461–71
    [Google Scholar]
  87. Munck A, Guyre PM 1991. Glucocorticoids and immune function. Psychoneuroimmunology 2 R Ader, DL Felten, N Cohen 446–74 San Diego, CA: Academic
    [Google Scholar]
  88. Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R et al. 2013. The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA 310:6591–606
    [Google Scholar]
  89. Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M 1988. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch. Gen. Psychiatry 45:6577–79
    [Google Scholar]
  90. Nemeroff CB, Widerlov E, Bissette G, Walleus H, Karlsson I et al. 1984. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:46801342–44
    [Google Scholar]
  91. Neumeister A 2003. Tryptophan depletion, serotonin, and depression: Where do we stand. ? Psychopharmacol. Bull. 37:499–115
    [Google Scholar]
  92. Newhouse P, Albert K 2015. Estrogen, stress, and depression: a neurocognitive model. JAMA Psychiatry 72:7727–29
    [Google Scholar]
  93. Newhouse P, Dumas J 2015. Estrogen–cholinergic interactions: implications for cognitive aging. Horm. Behav. 74:173–85
    [Google Scholar]
  94. Newhouse PA, Dumas J, Hancur-Bucci C, Naylor M, Sites CK et al. 2008. Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women. Neuropsychopharmacology 33:1514–527
    [Google Scholar]
  95. Nielsen SE, Ahmed I, Cahill L 2013. Sex and menstrual cycle phase at encoding influence emotional memory for gist and detail. Neurobiol. Learn. Mem. 106:56–65
    [Google Scholar]
  96. Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA et al. 2015. Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain. Behav. Immun. 48:8–18
    [Google Scholar]
  97. Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y et al. 2012. Estradiol rapidly rescues synaptic transmission from corticosterone-induced suppression via synaptic/extranuclear steroid receptors in the hippocampus. Cereb. Cortex 22:4926–36
    [Google Scholar]
  98. Phillips ML, Drevets WC, Rauch SL, Lane R 2003. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol. Psychiatry 54:515–28
    [Google Scholar]
  99. Phillips ML, Ladouceur CD, Drevets WC 2008. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol. Psychiatry 13:9829–57
    [Google Scholar]
  100. Piefke M, Weiss PH, Markowitsch HJ, Fink GR 2005. Gender differences in the functional neuroanatomy of emotional episodic autobiographical memory. Hum. Brain Mapp. 24:4313–24
    [Google Scholar]
  101. Poromaa IS, Gingnell M 2014. Menstrual cycle influence on cognitive function and emotion processing from a reproductive perspective. Front. Neurosci. 8:380
    [Google Scholar]
  102. Pourtois G, Schettino A, Vuilleumier P 2013. Brain mechanisms for emotional influences on perception and attention: What is magic and what is not. Biol. Psychol. 92492–512
  103. Pruessner JC, Dedovic K, Pruessner M, Lord C, Buss C et al. 2010. Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations. Psychoneuroendocrinology 351179–91
    [Google Scholar]
  104. Rocca WA, Bower JH, Maraganore DM, Ahlskog JE, Grossardt BR et al. 2007. Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause. Neurology 69:111074–83
    [Google Scholar]
  105. Rocca WA, Grossardt BR, Shuster LT 2014. Oophorectomy, estrogen, and dementia: a 2014 update. Mol. Cell. Endocrinol. 389:07–12
    [Google Scholar]
  106. Roiser JP, Levy J, Fromm SJ, Wang H, Hasler G et al. 2008. The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology 33:81992–2006
    [Google Scholar]
  107. Sanchez A, Vazquez C, Marker C, LeMoult J, Joormann J 2013. Attentional disengagement predicts stress recovery in depression: an eye-tracking study. J. Abnorm. Psychol 122:2303–13
    [Google Scholar]
  108. Sapolsky RM, Krey LC, McEwen BS 1986. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr. Rev. 7:3284–301
    [Google Scholar]
  109. Savitz JB, Drevets WC 2009. Imaging phenotypes of major depressive disorder: genetic correlates. Neuroscience 164:300–30
    [Google Scholar]
  110. Schmidt PJ, Rubinow DR 2009. Sex hormones and mood in the perimenopause. Ann. N. Y. Acad. Sci. 1179:70–85
    [Google Scholar]
  111. Sears CR, Newman KR, Ference JD, Thomas CL 2011. Attention to emotional images in previously depressed individuals: an eye-tracking study. Cogn. Ther. Res. 35:6517–28
    [Google Scholar]
  112. Shackman AJ, Maxwell JS, McMenamin BW, Greischar LL, Davidson RJ 2011. Stress potentiates early and attenuates late stages of visual processing. J. Neurosci. 31:31156–61
    [Google Scholar]
  113. Sheline YI 2000. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol. Psychiatry 48:8791–800
    [Google Scholar]
  114. Simpson JR, Drevets WC, Snyder AZ, Gusnard DA, Raichle ME 2001. Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety. PNAS 98:2688–93
    [Google Scholar]
  115. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA 2011. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:7361458–62
    [Google Scholar]
  116. Stokes PE 1995. The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. Eur. Neuropsychopharmacol. 5:Suppl.177–82
    [Google Scholar]
  117. Thompson AE, Voyer D 2014. Sex differences in the ability to recognise non-verbal displays of emotion: a meta-analysis. Cogn. Emot. 28:71164–95
    [Google Scholar]
  118. van Marle HJF, Hermans EJ, Qin S, Fernández G 2009. From specificity to sensitivity: how acute stress affects amygdala processing of biologically salient stimuli. Biol. Psychiatry 66:7649–55
    [Google Scholar]
  119. Videbech P, Ravnkilde B 2004. Hippocampal volume and depression: a meta-analysis of MRI studies. Am. J. Psychiatry 161:111957–66
    [Google Scholar]
  120. Vogel EK, Luck SJ 2000. The visual N1 component as an index of a discrimination process. Psychophysiology 37:2190–203
    [Google Scholar]
  121. Wang J, Korczykowski M, Rao H, Fan Y, Pluta J et al. 2007. Gender difference in neural response to psychological stress. Soc. Cogn. Affect. Neurosci. 2:3227–39
    [Google Scholar]
  122. Watanabe Y, Gould E, McEwen BS 1992. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588:2341–45
    [Google Scholar]
  123. Whittle S, Yücel M, Yap MBH, Allen NB 2011. Sex differences in the neural correlates of emotion: evidence from neuroimaging. Biol. Psychol. 87:319–33
    [Google Scholar]
  124. Widerlöv E, Bissette G, Nemeroff CB 1988. Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients. J. Affect. Disord. 14:299–107
    [Google Scholar]
  125. Young EA, Korszun A 2010. Sex, trauma, stress hormones and depression. Mol. Psychiatry 15:23–28
    [Google Scholar]
  126. Young EA, Midgley AR, Carlson NE, Brown MB 2000. Alteration in the hypothalamic–pituitary–ovarian axis in depressed women. Arch. Gen. Psychiatry 57:121157–62
    [Google Scholar]
  127. Zeidan MA, Igoe SA, Linnman C, Vitalo A, Levine JB et al. 2011. Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats. Biol. Psychiatry 70:10920–27
    [Google Scholar]
  128. Zhong M, Wang X, Xiao J, Yi J, Zhu X et al. 2011. Amygdala hyperactivation and prefrontal hypoactivation in subjects with cognitive vulnerability to depression. Biol. Psychol. 88:2–3233–42
    [Google Scholar]
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