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Abstract

Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on () antiviral immune responses with consequences for vaccine responses and infectious disease risk and () proinflammatory immune responses with implications for cardiovascular disease, cancer, and depression. This review also discusses the neuroendocrine and autonomic neural underpinnings linking sleep disturbance and immunity and the reciprocal links between sleep and inflammatory biology. Finally, interventions are discussed as effective strategies to improve sleep, and potential opportunities are identified to promote sleep health for therapeutic control of chronic infectious, inflammatory, and neuropsychiatric diseases.

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2015-01-03
2024-03-28
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Literature Cited

  1. Abedelmalek S, Chtourou H, Aloui A, Aouichaoui C, Souissi N, Tabka Z. 2013. Effect of time of day and partial sleep deprivation on plasma concentrations of IL-6 during a short-term maximal performance. Eur. J. Appl. Physiol. 113:241–48 [Google Scholar]
  2. Afshar R, Emany A, Saremi A, Shavandi N, Sanavi S. 2011. Effects of intradialytic aerobic training on sleep quality in hemodialysis patients. Iran J. Kidney Dis. 5:119–23 [Google Scholar]
  3. Am. Psychiatr. Assoc 2013. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: Am. Psychiatr. Publ, 5th ed..
  4. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP. 2003. The role of actigraphy in the study of sleep and circadian rhythms. Sleep 26:342–92 [Google Scholar]
  5. Andreakos E, Foxwell B, Feldmann M. 2004. Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?. Immunol. Rev. 202:250–65 [Google Scholar]
  6. Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer FE. et al. 2003. A prospective study of sleep duration and coronary heart disease in women. Arch. Intern. Med. 163:205–9 [Google Scholar]
  7. Azevedo Da Silva M, Singh-Manoux A, Shipley MJ, Vahtera J, Brunner EJ. et al. 2014. Sleep duration and sleep disturbances partly explain the association between depressive symptoms and cardiovascular mortality: the Whitehall II cohort study. J. Sleep Res. 23:94–97 [Google Scholar]
  8. Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C. et al. 2011. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J. Affect Disord. 135:10–19 [Google Scholar]
  9. Bauer J, Hohagen F, Gimmel E, Bruns F, Lis S. et al. 1995. Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression. Biol. Psychiatry 38:611–21 [Google Scholar]
  10. Baune BT, Rothermundt M, Ladwig KH, Meisinger C, Berger K. 2011. Systemic inflammation (interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO study. Age (Dordr.) 33:209–17 [Google Scholar]
  11. Besedovsky L, Lange T, Born J. 2012. Sleep and immune function. Pflugers Arch. 463:121–37 [Google Scholar]
  12. Black DS, Cole SW, Irwin MR, Breen E, St Cyr NM. et al. 2013. Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology 38:348–55 [Google Scholar]
  13. Bonnet MH, Arand DL. 1997. Hyperarousal and insomnia. Sleep Med. Rev. 1:97–108 [Google Scholar]
  14. Born J, Lange T, Hansen K, Molle M, Fehm HL. 1997. Effects of sleep and circadian rhythm on human circulating immune cells. J. Immunol. 158:4454–64 [Google Scholar]
  15. Boudreau P, Yeh WH, Dumont GA, Boivin DB. 2013. Circadian variation of heart rate variability across sleep stages. Sleep 36:1919–28 [Google Scholar]
  16. Brown R, Pang G, Husband AJ, King MG. 1989. Suppression of immunity to influenza virus infection in the respiratory tract following sleep disturbance. Reg. Immunol. 2:321–25 [Google Scholar]
  17. Burgos I, Richter L, Klein T, Fiebich B, Feige B. et al. 2006. Increased nocturnal interleukin-6 excretion in patients with primary insomnia: a pilot study. Brain Behav. Immun. 20:246–53 [Google Scholar]
  18. Buysse DJ. 2014. Sleep health: Can we define it? Does it matter?. Sleep 37:9–17 [Google Scholar]
  19. Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. 2011. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur. Heart J. 32:1484–92 [Google Scholar]
  20. Chennaoui M, Sauvet F, Drogou C, Van Beers P, Langrume C. et al. 2011. Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men. Cytokine 56:318–24 [Google Scholar]
  21. Chien KL, Chen PC, Hsu HC, Su TC, Sung FC. et al. 2010. Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort. Sleep 33:177–84 [Google Scholar]
  22. Chiu YL, Chuang YF, Fang KC, Liu SK, Chen HY. et al. 2009. Higher systemic inflammation is associated with poorer sleep quality in stable haemodialysis patients. Nephrol. Dial. Transpl. 24:247–51 [Google Scholar]
  23. Cho HJ, Lavretsky H, Olmstead R, Levin MJ, Oxman MN, Irwin MR. 2008. Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study. Am. J. Psychiatry 165:1543–50 [Google Scholar]
  24. Christian LM, Glaser R, Porter K, Malarkey WB, Beversdorf D, Kiecolt-Glaser JK. 2011. Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology 36:1495–504 [Google Scholar]
  25. Chung WS, Lin CL, Chen YF, Chiang JY, Sung FC. et al. 2013. Sleep disorders and increased risk of subsequent acute coronary syndrome in individuals without sleep apnea: a nationwide population-based cohort study. Sleep 36:1963–68 [Google Scholar]
  26. Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB. 2009. Sleep habits and susceptibility to the common cold. Arch. Intern. Med. 169:62–67 [Google Scholar]
  27. Cole JC, Motivala SJ, Buysse DJ, Oxman MN, Levin MJ, Irwin MR. 2006. Validation of a 3-factor scoring model for the Pittsburgh Sleep Quality Index in older adults. Sleep 29:112–16 [Google Scholar]
  28. Cole SW. 2009. Chronic inflammation and breast cancer recurrence. J. Clin. Oncol. 27:3418–19 [Google Scholar]
  29. Cole SW, Arevalo J, Takahashi R, Sloan EK, Lutgendorf S. et al. 2010. Computational identification of gene-social environment interaction at the human IL6 locus. Proc. Natl. Acad. Sci. USA 107:5681–86 [Google Scholar]
  30. Cole SW, Korin YD, Fahey JL, Zack JA. 1998. Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. J. Immunol. 161:610–16 [Google Scholar]
  31. Conlon M, Lightfoot N, Kreiger N. 2007. Rotating shift work and risk of prostate cancer. Epidemiology 18:182–83 [Google Scholar]
  32. Cover H, Irwin M. 1994. Immunity and depression: insomnia, retardation, and reduction of natural killer cell activity. J. Behav. Med. 17:217–23 [Google Scholar]
  33. Creswell JD, Irwin MR, Burklund LJ, Lieberman MD, Arevalo JM. et al. 2012. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav. Immun. 26:1095–101 [Google Scholar]
  34. Zambotti M, Covassin N, De Min Tona G, Sarlo M, Stegagno L. De 2011. Sleep onset and cardiovascular activity in primary insomnia. J. Sleep Res. 20:318–25 [Google Scholar]
  35. Dew MA, Hoch CC, Buysse DJ, Monk TH, Begely AE. et al. 2003. Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom. Med. 65:63–73 [Google Scholar]
  36. Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA. et al. 2006. Sleep enhances IL-6 trans-signaling in humans. FASEB J. 20:2174–76 [Google Scholar]
  37. Dimitrov S, Lange T, Tieken S, Fehm HL, Born J. 2004. Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav. Immun. 18:341–48 [Google Scholar]
  38. Dinges DF, Douglas SD, Hamarman S, Zaugg L, Kapoor S. 1995. Sleep deprivation and human immune function. Adv. Neuroimmunol. 5:97–110 [Google Scholar]
  39. Dinges DF, Douglas SD, Zaugg L, Campbell DE, McMann JM. et al. 1994. Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. J. Clin. Investig. 93:1930–39 [Google Scholar]
  40. Dowd JB, Goldman N, Weinstein M. 2011. Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population. Ann. Epidemiol. 21:799–806 [Google Scholar]
  41. Dryman A, Eaton WW. 1991. Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program. Acta Psychiatr. Scand. 84:1–5 [Google Scholar]
  42. Eisenberger NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. 2010a. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol. Psychiatry 68:748–54 [Google Scholar]
  43. Eisenberger NI, Inagaki TK, Mashal NM, Irwin MR. 2010b. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav. Immun. 24:558–63 [Google Scholar]
  44. Eisenberger NI, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. 2009. An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 47:881–90 [Google Scholar]
  45. Erten Y, Kokturk O, Yuksel A, Elbeg S, Ciftci TU. et al. 2005. Relationship between sleep complaints and proinflammatory cytokines in haemodialysis patients. Nephrology (Carlton) 10:330–35 [Google Scholar]
  46. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M. et al. 2003. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289:1799–804 [Google Scholar]
  47. Faraut B, Boudjeltia KZ, Dyzma M, Rousseau A, David E. et al. 2011. Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain Behav. Immun. 25:16–24 [Google Scholar]
  48. Fernandez-Mendoza J, Vgontzas AN, Liao D, Shaffer ML, Vela-Bueno A. et al. 2012. Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort. Hypertension 60:929–35 [Google Scholar]
  49. Ford DE, Kamerow DB. 1989. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?. JAMA 262:1479–84 [Google Scholar]
  50. Ford ES. 2002. Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology 13:561–68 [Google Scholar]
  51. Frey DJ, Fleshner M, Wright KP Jr. 2007. The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain Behav. Immun. 21:1050–57 [Google Scholar]
  52. Friedman EM. 2005. Social relationships, sleep quality, and interleukin-6 in aging women. Proc. Natl. Acad. Sci. USA 102:18757–62 [Google Scholar]
  53. Friedman EM, Hayney MS, Love GD, Urry HL, Rosenkranz MA. et al. 2005. Social relationships, sleep quality, and interleukin-6 in aging women. Proc. Natl. Acad. Sci. USA 102:18757–62 [Google Scholar]
  54. Gangwisch JE, Malaspina D, Posner K, Babiss LA, Heymsfield SB. et al. 2010. Insomnia and sleep duration as mediators of the relationship between depression and hypertension incidence. Am. J. Hypertens. 23:62–69 [Google Scholar]
  55. Gimeno D, Kivimaki M, Brunner EJ, Elovainio M, De Vogli R. et al. 2009. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol. Med. 39:413–23 [Google Scholar]
  56. Grandner MA, Perlis ML. 2013. Short sleep duration and insomnia associated with hypertension incidence. Hypertens. Res. 36:932–3 [Google Scholar]
  57. Haack M, Sanchez E, Mullington JM. 2007. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep 30:1145–52 [Google Scholar]
  58. Haus EL, Smolensky MH. 2013. Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation. Sleep Med. Rev. 17:273–84 [Google Scholar]
  59. Heslop P, Smith GD, Metcalfe C, Macleod J, Hart C. 2002. Sleep duration and mortality: the effect of short or long sleep duration on cardiovascular and all-cause mortality in working men and women. Sleep Med. 3:305–14 [Google Scholar]
  60. Hoevenaar-Blom MP, Spijkerman AM, Kromhout D, van den Berg JF, Verschuren WM. 2011. Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study. Sleep 34:1487–92 [Google Scholar]
  61. Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y. et al. 2009. Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: the JACC study. Sleep 32:295–301 [Google Scholar]
  62. Imeri L, Opp MR. 2009. How (and why) the immune system makes us sleep. Nat. Rev. Neurosci. 10:199–210 [Google Scholar]
  63. Irwin M, Mascovich A, Gillin JC, Willoughby R, Pike J, Smith TL. 1994. Partial sleep deprivation reduces natural killer cell activity in humans. Psychosom. Med. 56:493–98 [Google Scholar]
  64. Irwin M, McClintick J, Costlow C, Fortner M, White J, Gillin JC. 1996. Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB J. 10:643–53 [Google Scholar]
  65. Irwin M, Rinetti G, Redwine L, Motivala S, Dang J, Ehlers C. 2004. Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics. Brain Behav. Immun. 18:349–60 [Google Scholar]
  66. Irwin M, Thompson J, Miller C, Gillin JC, Ziegler M. 1999. Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J. Clin. Endocrinol. Metab. 84:1979–85 [Google Scholar]
  67. Irwin MR, Carrillo C, Olmstead R. 2010. Sleep loss activates cellular markers of inflammation: sex differences. Brain Behav. Immun. 24:54–57 [Google Scholar]
  68. Irwin MR, Cole JC, Nicassio PM. 2006a. Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age. Health Psychol. 25:3–14 [Google Scholar]
  69. Irwin MR, Cole SW. 2011. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 11:625–32 [Google Scholar]
  70. Irwin MR, Levin MJ, Laudenslager ML, Olmstead R, Lucko A. et al. 2013. Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications. Clin. Infect. Dis. 56:1085–93 [Google Scholar]
  71. Irwin MR, Miller AH. 2007. Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav. Immun. 21:374–83 [Google Scholar]
  72. Irwin MR, Olmstead R. 2012. Mitigating cellular inflammation in older adults: a randomized controlled trial of tai chi chih. Am. J. Geriatr. Psychiatry 20:764–72 [Google Scholar]
  73. Irwin MR, Olmstead R, Carrillo C, Sadeghi N, Breen EC. et al. 2014. Cognitive behavioral therapy versus tai chi for late life insomnia and inflammation: a randomized controlled comparative efficacy trial. Sleep 371543–52
  74. Irwin MR, Olmstead R, Motivala SJ. 2008a. Improving sleep quality in older adults with moderate sleep complaints: a randomized controlled trial of tai chi chih. Sleep 31:1001–8 [Google Scholar]
  75. Irwin MR, Olmstead R, Oxman MN. 2007. Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of tai chi. J. Am. Geriatr. Soc. 55:511–17 [Google Scholar]
  76. Irwin MR, Olmstead R, Valladares EM, Breen EC, Ehlers CL. 2009. Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence. Biol. Psychiatry 66:191–95 [Google Scholar]
  77. Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. 2006b. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch. Intern. Med. 166:1756–62 [Google Scholar]
  78. Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R. et al. 2008b. Sleep loss activates cellular inflammatory signaling. Biol. Psychiatry 64:538–40 [Google Scholar]
  79. Irwin MR, Ziegler M. 2005. Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics. Hypertension 45:252–57 [Google Scholar]
  80. Jaussent I, Bouyer J, Ancelin ML, Akbaraly T, Peres K. et al. 2011. Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly. Sleep 34:1103–10 [Google Scholar]
  81. Jiao L, Duan Z, Sangi-Haghpeykar H, Hale L, White DL, El-Serag HB. 2013. Sleep duration and incidence of colorectal cancer in postmenopausal women. Br. J. Cancer 108:213–21 [Google Scholar]
  82. Joynt KE, Whellan DJ, O'Connor CM. 2003. Depression and cardiovascular disease: mechanisms of interaction. Biol. Psychiatry 54:248–61 [Google Scholar]
  83. Karin M. 2006. Nuclear factor-κB in cancer development and progression. Nature 441:431–36 [Google Scholar]
  84. Ko YJ, Kwon YM, Kim KH, Choi HC, Chun SH. et al. 2012. High-sensitivity C-reactive protein levels and cancer mortality. Cancer Epidemiol. Biomark. Prev. 21:2076–86 [Google Scholar]
  85. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. 2002. Mortality associated with sleep duration and insomnia. Arch. Gen. Psychiatry 59:131–36 [Google Scholar]
  86. Kronfol Z, Nair M, Zhang Q, Hill EE, Brown MB. 1997. Circadian immune measures in healthy volunteers: relationship to hypothalamic-pituitary-adrenal axis hormones and sympathetic neurotransmitters. Psychosom. Med. 59:42–50 [Google Scholar]
  87. Kronholm E, Laatikainen T, Peltonen M, Sippola R, Partonen T. 2011. Self-reported sleep duration, all-cause mortality, cardiovascular mortality and morbidity in Finland. Sleep Med. 12:215–21 [Google Scholar]
  88. Kubo T, Oyama I, Nakamura T, Shirane K, Otsuka H. et al. 2011. Retrospective cohort study of the risk of obesity among shift workers: findings from the Industry-Based Shift Workers' Health study, Japan. Occup. Environ. Med. 68:327–31 [Google Scholar]
  89. Kubo T, Ozasa K, Mikami K, Wakai K, Fujino Y. et al. 2006. Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am. J. Epidemiol. 164:549–55 [Google Scholar]
  90. Lanfranchi PA, Pennestri MH, Fradette L, Dumont M, Morin CM, Montplaisir J. 2009. Nighttime blood pressure in normotensive subjects with chronic insomnia: implications for cardiovascular risk. Sleep 32:760–66 [Google Scholar]
  91. Lange T, Dimitrov S, Bollinger T, Diekelmann S, Born J. 2011. Sleep after vaccination boosts immunological memory. J. Immunol. 187:283–90 [Google Scholar]
  92. Lange T, Dimitrov S, Born J. 2010. Effects of sleep and circadian rhythm on the human immune system. Ann. N. Y. Acad. Sci. 1193:48–59 [Google Scholar]
  93. Lange T, Dimitrov S, Fehm HL, Born J. 2006a. Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells. Int. Immunopharmacol. 6:216–25 [Google Scholar]
  94. Lange T, Dimitrov S, Fehm HL, Westermann J, Born J. 2006b. Shift of monocyte function toward cellular immunity during sleep. Arch. Intern. Med. 166:1695–700 [Google Scholar]
  95. Lange T, Marshall L, Spath-Schwalbe E, Fehm HL, Born J. 2002. Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men. Brain Behav. Immun. 16:663–74 [Google Scholar]
  96. Lange T, Perras B, Fehm HL, Born J. 2003. Sleep enhances the human antibody response to hepatitis A vaccination. Psychosom. Med. 65:831–35 [Google Scholar]
  97. Larkin EK, Rosen CL, Kirchner HL, Storfer-Isser A, Emancipator JL. et al. 2005. Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration. Circulation 111:1978–84 [Google Scholar]
  98. Laugsand LE, Vatten LJ, Bjorngaard JH, Hveem K, Janszky I. 2012. Insomnia and high-sensitivity C-reactive protein: the HUNT study, Norway. Psychosom. Med. 74:543–53 [Google Scholar]
  99. LeBlanc M, Merette C, Savard J, Ivers H, Baillargeon L, Morin CM. 2009. Incidence and risk factors of insomnia in a population-based sample. Sleep 32:1027–37 [Google Scholar]
  100. Lee E, Cho HJ, Olmstead R, Levin MJ, Oxman MN, Irwin MR. 2013. Persistent sleep disturbance: a risk factor for recurrent depression in community-dwelling older adults. Sleep 36:1685–91 [Google Scholar]
  101. Lee JH, Kim SJ, Jung HH. 2009. Nocturnal sleep related with metabolic markers in end-stage renal disease patients receiving hemodialysis. Psychiatry Investig. 6:34–38 [Google Scholar]
  102. Libby P, Ridket PM, Maseri A. 2002. Inflammation and atherosclerosis. Circulation 105:1135–43 [Google Scholar]
  103. Lissoni P, Rovelli F, Brivio F, Brivio O, Fumagalli L. 1998. Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans. Nat. Immun. 16:1–5 [Google Scholar]
  104. Littner M, Hirshkowitz M, Kramer M, Kapen S, Anderson WM. et al. 2003. Practice parameters for using polysomnography to evaluate insomnia: an update. Sleep 26:754–60 [Google Scholar]
  105. Liukkonen T, Rasanen P, Ruokonen A, Laitinen J, Jokelainen J. et al. 2007. C-reactive protein levels and sleep disturbances: observations based on the Northern Finland 1966 Birth Cohort study. Psychosom. Med. 69:756–61 [Google Scholar]
  106. Mallon L, Broman JE, Hetta J. 2002. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J. Intern. Med. 251:207–16 [Google Scholar]
  107. Manber R, Edinger JD, Gress JL, San Pedro-Salcedo MG, Kuo TF, Kalista T. 2008. Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia. Sleep 31:489–95 [Google Scholar]
  108. Mantovani A, Allavena P, Sica A, Balkwill F. 2008. Cancer-related inflammation. Nature 454:436–44 [Google Scholar]
  109. Marsland AL, Gianaros PJ, Abramowitch SM, Manuck SB, Hariri AR. 2008. Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biol. Psychiatry 64:484–90 [Google Scholar]
  110. Medzhitov R. 2008. Origin and physiological roles of inflammation. Nature 454:428–35 [Google Scholar]
  111. Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ. et al. 2004. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J. Am. Coll. Cardiol. 43:678–83 [Google Scholar]
  112. Meng L, Zheng Y, Hui R. 2013. The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies. Hypertens. Res. 36:985–95 [Google Scholar]
  113. Miller GE, Cohen S, Pressman S, Barkin A, Rabin BS, Treanor JJ. 2004. Psychological stress and antibody response to influenza vaccination: When is the critical period for stress, and how does it get inside the body?. Psychosom. Med. 66:215–23 [Google Scholar]
  114. Miller MA, Kandala NB, Kivimaki M, Kumari M, Brunner EJ. et al. 2009. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep 32:857–64 [Google Scholar]
  115. Moldofsky H, Lue FA, Davidson JR, Gorczynski R. 1989. Effects of sleep deprivation on human immune functions. FASEB J. 3:1972–77 [Google Scholar]
  116. Morin CM, Belanger L, LeBlanc M, Ivers H, Savard J. et al. 2009. The natural history of insomnia: a population-based 3-year longitudinal study. Arch. Intern. Med. 169:447–53 [Google Scholar]
  117. Morin CM, Belleville G, Belanger L, Ivers H. 2011. The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 34:601–8 [Google Scholar]
  118. Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL. 2006a. Psychological and behavioral treatment of insomnia: update of the recent evidence (1998–2004). Sleep 29:1398–414 [Google Scholar]
  119. Morin CM, LeBlanc M, Daley M, Gregoire JP, Merette C. 2006b. Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med. 7:123–30 [Google Scholar]
  120. Motivala S, Irwin MR. 2007. Sleep and immunity: cytokine pathways linking sleep and health outcomes. Curr. Dir. Psychol. Sci. 16:21–25 [Google Scholar]
  121. Mullington J, Korth C, Hermann DM, Orth A, Galanos C. et al. 2000. Dose-dependent effects of endotoxin on human sleep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:R947–55 [Google Scholar]
  122. Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. 2009. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. Prog. Cardiovasc. Dis. 51:294–302 [Google Scholar]
  123. Murphy K. 2011. Janeway's Immunobiology New York: Garland Sci.
  124. Murray DR, Irwin M, Rearden CA, Ziegler M, Motulsky H, Maisel AS. 1992. Sympathetic and immune interactions during dynamic exercise: mediation via beta 2-adrenergic-dependent mechanism. Circulation 83:203–13 [Google Scholar]
  125. Ohayon M. 1996. Epidemiological study on insomnia in the general population. Sleep 19:S7–15 [Google Scholar]
  126. Ohayon MM. 2002. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med. Rev. 6:97–111 [Google Scholar]
  127. Ohayon MM, Riemann D, Morin C, Reynolds CF 3rd. 2012. Hierarchy of insomnia criteria based on daytime consequences. Sleep Med. 13:52–57 [Google Scholar]
  128. Okun ML, Coussons-Read M, Hall M. 2009. Disturbed sleep is associated with increased C-reactive protein in young women. Brain Behav. Immun. 23:351–54 [Google Scholar]
  129. Okun ML, Coussons-Read ME. 2007. Sleep disruption during pregnancy: How does it influence serum cytokines?. J. Reprod. Immunol. 73:158–65 [Google Scholar]
  130. Okun ML, Hall M, Coussons-Read ME. 2007. Sleep disturbances increase interleukin-6 production during pregnancy: implications for pregnancy complications. Reprod. Sci. 14:560–67 [Google Scholar]
  131. Palagini L, Bruno RM, Gemignani A, Baglioni C, Ghiadoni L, Riemann D. 2013. Sleep loss and hypertension: a systematic review. Curr. Pharm. Des. 19:2409–19 [Google Scholar]
  132. Parent ME, El-Zein M, Rousseau MC, Pintos J, Siemiatycki J. 2012. Night work and the risk of cancer among men. Am. J. Epidemiol. 176:751–59 [Google Scholar]
  133. Patel SR, Malhotra A, Gao X, Hu FB, Neuman MI, Fawzi WW. 2012. A prospective study of sleep duration and pneumonia risk in women. Sleep 35:97–101 [Google Scholar]
  134. Patel SR, Zhu X, Storfer-Isser A, Mehra R, Jenny NS. et al. 2009. Sleep duration and biomarkers of inflammation. Sleep 32:200–4 [Google Scholar]
  135. Petrovsky N, Harrison LC. 1997. Diurnal rhythmicity of human cytokine production. J. Immunol. 158:5163–68 [Google Scholar]
  136. Petrovsky N, McNair P, Harrison LC. 1998. Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications. Cytokine 10:307–12 [Google Scholar]
  137. Phillips B, Bůzková P, Enright P, Cardiovasc. Health Study Res. Group 2009. Insomnia did not predict incident hypertension in older adults in the cardiovascular health study. Sleep 32:65–72 [Google Scholar]
  138. Phillips B, Mannino DM. 2007. Do insomnia complaints cause hypertension or cardiovascular disease?. J. Clin. Sleep Med. 3:489–94 [Google Scholar]
  139. Pierce BL, Ballard-Barbash R, Bernstein L, Baumgartner RN, Neuhouser ML. et al. 2009. Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J. Clin. Oncol. 27:3437–44 [Google Scholar]
  140. Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. 2000. Experimental immunomodulation, sleep, and sleepiness in humans. Ann. N. Y. Acad. Sci. 917:488–99 [Google Scholar]
  141. Prather AA, Hall M, Fury JM, Ross DC, Muldoon MF. et al. 2012. Sleep and antibody response to hepatitis B vaccination. Sleep 35:1063–69 [Google Scholar]
  142. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. 2005. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. 24:297–306 [Google Scholar]
  143. Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P. et al. 2013. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31–41 [Google Scholar]
  144. Raison CL, Rye DB, Woolwine BJ, Vogt GJ, Bautista BM. et al. 2010. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol. Psychiatry 68:942–49 [Google Scholar]
  145. Ramey SL, Perkhounkova Y, Moon M, Budde L, Tseng HC, Clark MK. 2012. The effect of work shift and sleep duration on various aspects of police officers' health. Workplace Health Saf. 60:215–22 [Google Scholar]
  146. Razeghi E, Sahraian MA, Heidari R, Bagherzadeh M. 2012. Association of inflammatory biomarkers with sleep disorders in hemodialysis patients. Acta Neurol. Belg. 112:45–49 [Google Scholar]
  147. Redwine L, Dang J, Hall M, Irwin M. 2003. Disordered sleep, nocturnal cytokines, and immunity in alcoholics. Psychosom. Med. 65:75–85 [Google Scholar]
  148. Redwine L, Hauger RL, Gillin JC, Irwin M. 2000. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J. Clin. Endocrinol. Metab. 85:3597–603 [Google Scholar]
  149. Reid S, Dwyer J. 2005. Insomnia in HIV infection: a systematic review of prevalence, correlates, and management. Psychosom. Med. 67:260–69 [Google Scholar]
  150. Renegar KB, Crouse D, Floyd RA, Krueger J. 2000. Progression of influenza viral infection through the murine respiratory tract: the protective role of sleep deprivation. Sleep 23:859–63 [Google Scholar]
  151. Renegar KB, Floyd R, Krueger JM. 1998a. Effect of sleep deprivation on serum influenza-specific IgG. Sleep 21:19–24 [Google Scholar]
  152. Renegar KB, Floyd RA, Krueger JM. 1998b. Effects of short-term sleep deprivation on murine immunity to influenza virus in young adult and senescent mice. Sleep 21:241–48 [Google Scholar]
  153. Rief W, Mills PJ, Ancoli-Israel S, Ziegler MG, Pung MA, Dimsdale JE. 2010. Overnight changes of immune parameters and catecholamines are associated with mood and stress. Psychosom. Med. 72:755–62 [Google Scholar]
  154. Riemann D. 2010. Hyperarousal and insomnia: state of the science. Sleep Med. Rev. 14:17 [Google Scholar]
  155. Sabanayagam C, Shankar A, Buchwald D, Goins RT. 2011. Insomnia symptoms and cardiovascular disease among older American Indians: the Native Elder Care Study. J. Environ. Public Health 2011:964617 [Google Scholar]
  156. Satoh M, Shimoda Y, Maesawa C, Akatsu T, Ishikawa Y. et al. 2005. Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction. Int. J. Cardiol. 109:226–34 [Google Scholar]
  157. Sauvet F, Leftheriotis G, Gomez-Merino D, Langrume C, Drogou C. et al. 2010. Effect of acute sleep deprivation on vascular function in healthy subjects. J. Appl. Physiol. 108:68–75 [Google Scholar]
  158. Savard J, Laroche L, Simard S, Ivers H, Morin CM. 2003. Chronic insomnia and immune functioning. Psychosom. Med. 65:211–21 [Google Scholar]
  159. Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Lehnert H. et al. 2011. Disturbed glucoregulatory response to food intake after moderate sleep restriction. Sleep 34:371–77 [Google Scholar]
  160. Schwartzbaum J, Ahlbom A, Feychting M. 2007. Cohort study of cancer risk among male and female shift workers. Scand. J. Work Environ. Health 33:336–43 [Google Scholar]
  161. Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN. et al. 2001. Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J. Allergy Clin. Immunol. 107:165–70 [Google Scholar]
  162. Shiels MS, Pfeiffer RM, Hildesheim A, Engels EA, Kemp TJ. et al. 2013. Circulating inflammation markers and prospective risk for lung cancer. J. Natl. Cancer Inst. 105:1871–80 [Google Scholar]
  163. Siemes C, Visser LE, Coebergh JW, Splinter TA, Witteman JC. et al. 2006. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J. Clin. Oncol. 24:5216–22 [Google Scholar]
  164. Sigurdardottir LG, Valdimarsdottir UA, Mucci LA, Fall K, Rider JR. et al. 2013. Sleep disruption among older men and risk of prostate cancer. Cancer Epidemiol. Biomark. Prev. 22:872–79 [Google Scholar]
  165. Slavich GM, Irwin MR. 2014. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol. Bull. 140:774–815 [Google Scholar]
  166. Somers VK, Dyken ME, Mark AL, Abboud FM. 1993. Sympathetic-nerve activity during sleep in normal subjects. N. Engl. J. Med. 328:303–7 [Google Scholar]
  167. Spath-Schwalbe E, Hansen K, Schmidt F, Schrezenmeier H, Marshall L. et al. 1998. Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J. Clin. Endocrinol. Metab. 83:1573–79 [Google Scholar]
  168. Spath-Schwalbe E, Lange T, Perras B, Fehm HL, Born J. 2000. Interferon-α acutely impairs sleep in healthy humans. Cytokine 12:518–21 [Google Scholar]
  169. Spiegel K, Sheridan JF, Van Cauter E. 2002. Effect of sleep deprivation on response to immunization. JAMA 288:1471–72 [Google Scholar]
  170. Stamatakis KA, Punjabi NM. 2010. Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest 137:95–101 [Google Scholar]
  171. Stenholm S, Kronholm E, Bandinelli S, Guralnik JM, Ferrucci L. 2011. Self-reported sleep duration and time in bed as predictors of physical function decline: results from the InCHIANTI study. Sleep 34:1583–93 [Google Scholar]
  172. Suarez EC. 2008. Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav. Immun. 22:960–68 [Google Scholar]
  173. Suka M, Yoshida K, Sugimori H. 2003. Persistent insomnia is a predictor of hypertension in Japanese male workers. J. Occup. Health 45:344–50 [Google Scholar]
  174. Suzuki E, Yorifuji T, Ueshima K, Takao S, Sugiyama M. et al. 2009. Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: a population-based cohort study. Prev. Med. 49:135–41 [Google Scholar]
  175. Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E. 2007. Correlates of serum C-reactive protein (CRP)—no association with sleep duration or sleep disordered breathing. Sleep 30:991–96 [Google Scholar]
  176. Taveras EM, Rifas-Shiman SL, Rich-Edwards JW, Mantzoros CS. 2011. Maternal short sleep duration is associated with increased levels of inflammatory markers at 3 years postpartum. Metabolism 60:982–86 [Google Scholar]
  177. Toth LA. 1995. Sleep, sleep deprivation and infectious disease: studies in animals. Adv. Neuroimmunol. 5:79–92 [Google Scholar]
  178. Touvier M, Fezeu L, Ahluwalia N, Julia C, Charnaux N. et al. 2013. Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study. Am. J. Epidemiol. 177:3–13 [Google Scholar]
  179. Tyring S, Gottlieb A, Papp K, Gordon K, Leonardi C. et al. 2006. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 367:29–35 [Google Scholar]
  180. van Leeuwen WMA, Lehto M, Karisola P, Lindholm H, Luukkonen R. et al. 2009. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLOS ONE 4:e4589 [Google Scholar]
  181. van Mark A, Weiler SW, Schröder M, Otto A, Jauch-Chara K. et al. 2010. The impact of shift work induced chronic circadian disruption on IL-6 and TNF-α immune responses. J. Occup. Med. Toxicol. 5:18 [Google Scholar]
  182. Vgontzas AN, Fernandez-Mendoza J, Liao D, Bixler EO. 2013. Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder. Sleep Med. Rev. 17:241–54 [Google Scholar]
  183. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-Bueno A. 2009. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep 32:491–97 [Google Scholar]
  184. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K. et al. 1999. Circadian interleukin-6 secretion and quantity and depth of sleep. J. Clin. Endocrinol. Metab. 84:2603–7 [Google Scholar]
  185. Vgontzas AN, Pejovic S, Zoumakis E, Lin HM, Bixler EO. et al. 2007. Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. Am. J. Physiol. Endocrinol. Metab. 292:E253–61 [Google Scholar]
  186. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H. et al. 2004a. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J. Clin. Endocrinol. Metab. 89:2119–26 [Google Scholar]
  187. Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, Chrousos GP. 2004b. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-α antagonist. J. Clin. Endocrinol. Metab. 89:4409–13 [Google Scholar]
  188. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P. et al. 2002. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism 51:887–92 [Google Scholar]
  189. Vogtmann E, Levitan EB, Hale L, Shikany JM, Shah NA. et al. 2013. Association between sleep and breast cancer incidence among postmenopausal women in the women's health initiative. Sleep 36:1437–44 [Google Scholar]
  190. von Ruesten A, Weikert C, Fietze I, Boeing H. 2012. Association of sleep duration with chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. PLOS ONE 7:e30972 [Google Scholar]
  191. Vozoris NT. 2013. The relationship between insomnia symptoms and hypertension using United States population-level data. J. Hypertens. 31:663–71 [Google Scholar]
  192. Wang Q, Xi B, Liu M, Zhang Y, Fu M. 2012. Short sleep duration is associated with hypertension risk among adults: a systematic review and meta-analysis. Hypertens. Res. 35:1012–18 [Google Scholar]
  193. Youngstedt SD, Kripke DF. 2004. Long sleep and mortality: rationale for sleep restriction. Sleep Med. Rev. 8:159–74 [Google Scholar]
  194. Zamarron F, Maceiras F, Mera A, Gomez-Reino JJ. 2004. Effects of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis. Ann. Rheum. Dis. 63:88–90 [Google Scholar]
  195. Zautra AJ, Davis MC, Reich JW, Nicassio P, Tennen H. et al. 2008. Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. J. Consult. Clin. Psychol. 76:408–21 [Google Scholar]
  196. Zhang J, Lamers F, Hickie IB, He JP, Feig E, Merikangas KR. 2013a. Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates. Sleep 36:671–79 [Google Scholar]
  197. Zhang X, Giovannucci EL, Wu K, Gao X, Hu F. et al. 2013b. Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women. Sleep 36:681–88 [Google Scholar]
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