1932

Abstract

Recent structural and biochemical investigations have come together to allow a better understanding of the mechanism of chaperonin (GroEL, Hsp60)–mediated protein folding, the final step in the accurate expression of genetic information. Major, asymmetric conformational changes in the GroEL double toroid accompany binding of ATP and the cochaperonin GroES. When a nonnative polypeptide, bound to one of the GroEL rings, is encapsulated by GroES to form a ternary complex, these changes drive the polypeptide into the sequestered cavity and initiate its folding. ATP hydrolysis in the ring primes release of the products, and ATP binding in the ring then disrupts the complex. This process allows the polypeptide to achieve its final native state, if folding was completed, or to recycle to another chaperonin molecule, if the folding process did not result in a form committed to the native state.

Keyword(s): ATPchaperoninGroESHsp60
Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.67.1.581
1998-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/biochem/67/1/annurev.biochem.67.1.581.html?itemId=/content/journals/10.1146/annurev.biochem.67.1.581&mimeType=html&fmt=ahah

Literature Cited

  1. Dill KA, Chan HS. 1997. Nat. Struct. Biol. 4:10–19
  2. Flynn GC, Chappell TG, Rothman JE. 1989. Science 245:385–90
  3. Zhu XT, Zhao X, Burkholder WF, Gragerov A, Ogata CM. et al. 1996. Science 272:1606–14
  4. Rudiger S, Germeroth L, Schneider-Mergener J, Bukau B. 1997. EMBO J. 16:1501–7
  5. Rudiger S, Buchberger A, Bukau B. 1997. Nat. Struct. Biol. 4:342–49
  6. Ehrnsperger M, Gräber S, Gaestel M, Buchner J. 1997. EMBO J. 16:221–29
  7. Lee GJ, Roseman AM, Saibil HR, Vierling E. 1997. EMBO J. 16:659–71
  8. Sullivan W, Stensgard B, Caucutt G, Bartha B, McMahon N. et al. 1997. J. Biol. Chem. 272:8007–12
  9. Bohen SP, Kralli A, Yamamoto KR. 1995. Science 268:1303–4
  10. Fenton WA, Horwich AL. 1997. Protein Sci. 6:743–60
  11. Ellis RJ. ed 1996. The Chaperonins. San Diego, CA: Academic [Google Scholar]
  12. Hartl F-U. 1996. Nature 381:571–80
  13. Hendrix RW. 1979. J. Mol. Biol. 129:375–92
  14. Hohn T, Hohn B, Engel A, Wurtz M, Smith PR. 1979. J. Mol. Biol. 129:359–73
  15. Tilly K, Murialdo H, Georgopoulos C. 1981. Proc. Natl. Acad. Sci. USA 78:1629–33
  16. Chandrasekhar GN, Tilly K, Woolford C, Hendrix R, Georgopoulos C. 1986. J. Biol. Chem. 261:12414–19
  17. Saibil H, Dong Z, Wood S, auf der Mauer A. 1991. Nature 353:25–26
  18. Langer T, Pfeifer G, Martin J, Baumeister W, Hartl F-U. 1992. EMBO J. 11:4757–65
  19. Ishii N, Taguchi H, Sumi M, Yoshida M. 1992. FEBS Lett. 299:169–74
  20. Azem A, Kessel M, Goloubinoff P. 1994. Science 265:653–56
  21. Schmidt M, Rutkat K, Rachel R, Pfeifer G, Jaenicke R. et al. 1994. Science 265:656–59
  22. Engel A, Hayer-Hartl MK, Goldie KN, Pfeifer G, Hegerl R. et al. 1995. Science 269:832–36
  23. Azem A, Diamant S, Kessel M, Weiss C, Goloubinoff P. 1995. Proc. Natl. Acad. Sci. USA 92:12021–25
  24. Braig K, Simon M, Furaya F, Hainfeld JF, Horwich AL. 1993. Proc. Natl. Acad. Sci. USA 90:3978–82
  25. Chen S, Roseman AM, Hunter AS, Wood SP, Burston SG. et al. 1994. Nature 371:261–64
  26. Thiyagarajan P, Henderson SJ, Joachimiak A. 1996. Structure 4:79–88
  27. Phipps BM, Hoffmann A, Stetter KO, Baumeister W. 1991. EMBO J. 10:1711–22
  28. Trent JD, Nimmesgern E, Wall JS, Hartl F-U, Horwich AL. 1991. Nature 354:490–93
  29. Liou AKF, Willison KR. 1997. EMBO J. 16:4311–16
  30. Horwich AL, Willison KR. 1993. Philos. Trans. R. Soc. London Ser. B 339:313–26
  31. Kubota H, Hynes G, Carne A, Ashworth A, Willison K. 1994. Curr. Biol. 4:89–99
  32. Lewis SA, Tian G, Vainberg IE, Cowan NJ. 1996. J. Cell Biol. 132:1–4
  33. Braig K, Otwinowski Z, Hegde R, Boisvert DC, Joachimiak A. et al. 1994. Nature 371:578–86
  34. Hunt JF, Weaver AJ, Landry SJ, Gierasch L, Deisenhofer J. 1996. Nature 379:37–45
  35. Mande SC, Mehra V, Bloom BR, Hol WGJ. 1996. Science 271:203–7
  36. Landry SJ, Zeilstra-Ryalls J, Fayet O, Georgopoulos C, Gierasch LM. 1993. Nature 364:255–58
  37. Goloubinoff P, Christeller JT, Gatenby AA, Lorimer GH. 1989. Nature 342:884–89
  38. Saibil HR, Zheng D, Roseman AM, Hunter AS, Watson GMF. et al. 1993. Curr. Biol. 3:265–73
  39. Weissman JS, Rye HS, Fenton WA, Beechem JM, Horwich AL. 1996. Cell 84:481–90
  40. Rye HS, Burston SG, Fenton WA, Beechem JM, Xu Z. et al. 1997. Nature 388:792–98
  41. Fenton WA, Kashi Y, Furtak K, Horwich AL. 1994. Nature 371:614–19
  42. Lin ZL, Schwarz FP, Eisenstein E. 1995. J. Biol. Chem. 270:1011–14
  43. Itzhaki LS, Otzen DE, Fersht AR. 1995. Biochemistry 34:14581–87
  44. Katsumata K, Okazaki A, Tsurupa GP, Kuwajima K. 1996. J. Mol. Biol. 264:643–49
  45. Perrett S, Zahn R, Sternberg G, Fersht AR. 1997. J. Mol. Biol. 269:892–901
  46. Landry SJ, Gierasch LM. 1991. Biochemistry 30:7359–62
  47. Buckle AM, Zahn R, Fersht AR. 1997. Proc. Natl. Acad. Sci. USA 94:3571–75
  48. Zahn R, Perrett S, Stenberg G, Fersht AR. 1996. Science 271:642–45
  49. Lorimer G. 1997. Nature 388:720–23
  50. Zahn R, Pluckthun A. 1994. J. Mol. Biol. 242:165–74
  51. Walter S, Lorimer GH, Schmid FX. 1996. Proc. Natl. Acad. Sci. USA 93:9425–30
  52. Viitanen PV, Donaldson GK, Lorimer GH, Lubben TH, Gatenby AA. 1991. Biochemistry 30:9716–23
  53. Zahn R, Spitzfaden C, Ottiger M, Wuthrich K, Pluckthun A. 1994. Nature 368:261–65
  54. Robinson CV, Groß M, Eyles SJ, Ewbank JJ, Mayhew M. et al. 1994. Nature 372:646–51
  55. Goldberg MS, Zhang J, Sondek S, Matthews CR, Fox RO, Horwich AL. 1997. Proc. Natl. Acad. Sci. USA 94:1080–85
  56. Groß M, Robinson CV, Mayhew M, Hartl F-U, Radford SE. 1996. Protein Sci. 5:2506–13
  57. Ranson NA, Dunster NJ, Burston SG, Clarke AR. 1995. J. Mol. Biol. 250:581–86
  58. Laminet AA, Ziegelhoffer T, Georgopoulos C, Pluckthun A. 1990. EMBO J. 9:2315–19
  59. Viitanen PV, Lubben TH, Reed J, Goloubinoff P, O'Keefe DP, Lorimer GH. 1990. Biochemistry 29:5665–71
  60. Martin J, Langer T, Boteva R, Schramel A, Horwich AL, Hartl F-U. 1991. Nature 352:36–42
  61. Buchner J, Schmidt M, Fuchs M, Jaenicke R, Rudolph R. et al. 1991. Biochemistry 30:1586–91
  62. Badcoe IG, Smith CJ, Wood S, Halsall DJ, Holbrook JJ. et al. 1991. Biochemistry 30:9195–9200
  63. Gray TE, Fersht AR. 1991. FEBS Lett. 292:254–58
  64. Bochkareva ES, Lissin NM, Flynn GC, Rothman JE, Girshovich AS. 1992. J. Biol. Chem. 267:6796–800
  65. Jackson GS, Staniforth RA, Halsall DJ, Atkinson T, Holbrook JJ. et al. 1993. Biochemistry 32:2554–63
  66. Todd MJ, Viitanen PV, Lorimer GH. 1993. Biochemistry 32:8560–67
  67. Burston SG, Ranson NA, Clarke AR. 1995. J. Mol. Biol. 249:138–52
  68. Roseman AM, Chen SX, White H, Braig K, Saibil HR. 1996. Cell 87:241–51
  69. Yifrach O, Horovitz A. 1995. Biochemistry 34:9716–23
  70. Boisvert DC, Wang JM, Otwinowski Z, Horwich AL, Sigler PB. 1996. Nat. Struct. Biol. 3:170–77
  71. Kim S, Willison KR, Horwich AL. 1994. Trends Biochem. Sci. 19:543–48
  72. Braig K, Adams PD, Brunger AT. 1995. Nat. Struct. Biol. 2:1083–94
  73. Aharoni A, Horovitz A. 1996. J. Mol. Biol. 258:732–35
  74. Xu Z, Horwich AL, Sigler PB. 1997. Nature 388:741–50
  75. Murai N, Makino Y, Yoshida M. 1996. J. Biol. Chem. 271:28229–34
  76. Todd MJ, Viitanen PV, Lorimer GH. 1994. Science 265:659–66
  77. Klumpp M, Baumeister W, Essen L-O. 1977. Cell 91:263–70
  78. Zeilstra-Ryalls J, Fayet O, Georgopoulos C. 1996. FASEB J. 10:148–52
  79. Hunt JF, van der Vies SM, Henry L, Deisenhofer J. 1997. Cell 90:361–71
  80. Burston SG, Weissman JS, Farr GW, Fenton WA, Horwich AL. 1996. Nature 383:96–99
  81. Weissman JS, Kashi Y, Fenton WA, Horwich AL. 1994. Cell 78:693–702
  82. Smith KE, Fisher MT. 1995. J. Biol. Chem. 270:21517–23
  83. Taguchi H, Yoshida M. 1995. FEBS Lett. 359:195–98
  84. Mayhew M, da Silva ACR, Martin J, Erdjument-Bromage H, Tempst P, Hartl F-U. 1996. Nature 379:420–26
/content/journals/10.1146/annurev.biochem.67.1.581
Loading
/content/journals/10.1146/annurev.biochem.67.1.581
Loading

Data & Media loading...

  • Article Type: Introduction
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error