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  1. Eukaryotic Ribosome Assembly

    Jochen Baßler and Ed Hurt
    Annual Review of Biochemistry
    Vol. 88, 2019

    Abstract - Figures - Supplemental MaterialsPreview


    Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal proteins, which coassemble hierarchically during a process termed ribosome biogenesis. Historically, biochemical and molecular biology approaches have revealed how ...Read More

    Supplemental Materials

    Supplemental Video 1, Supplemental Figures 1-2, and Supplemental Tables 1-3 Read More


    Figure 1: Overview of the eukaryotic ribosome assembly pathway. Ribosome assembly requires all three RNA polymerases: Pol I synthesizing the 35S rRNA precursor, Pol III synthesizing the 5S rRNA, and P...


    Figure 2: Cryo–electron microscopy (cryo-EM) structure of the 90S preribosomal particle isolated from Chaetomium thermophilum. (a) The cryo-EM structure of the 90S preribosome with rRNA, r-proteins, U...


    Figure 3: Evolutionary conservation of pre-40S particles from yeast to human. (a) Comparison of cryo-EM structures of pre-40S particles from human (left) and the yeast Saccharomyces cerevisiae (right)...


    Figure 4: Folding and maturation of the 5.8S and 25S rRNA within the early nucleolar pre-60S particles. (a) The first rRNA precursor of the large subunit (27SA2) contains ITS1, ITS2, domain I–IV, and ...


    Figure 5: Removal of ITS2 from the pre-60S particle by the successive and coordinated action of different RNA processing enzymes. (a) Cartoon representation showing intermediates during ITS2 (light bl...


    Figure 6: Structural snapshots of the eukaryotic ribosome assembly pathway. Cryo-EM structures of preribosomal particles are depicted according to their spatiotemporal assembly and maturation pathway,...

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