“In just a few short years, CRISPR/Cas9 genome editing has fundamentally changed basic, agricultural, and biomedical research, but no field has felt a more profound impact than cancer research. The ability to quickly and precisely manipulate the genome has opened the floodgates for a new and more elaborate understanding of how genes and gene regulation influence disease.” -Andrea Ventura and Lukas E. Dow
April 25 is DNA Day, founded by the US NIH National Human Genome Research Institute to commemorate the completion of the Human Genome Project in 2003 as well as the initial discovery of DNA’s double helix in 1953. In less than twenty years, genomics has changed what is possible for both health care and food security.
This curated article collection includes 18 reviews of research from pioneers and leaders on ethics, public benefits, and concerns of genomics. Interdisciplinary research on basic science and the potential of genomic projects is also highlighted.
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Genomics, Ethics, and Public Benefits
Ethics of Human Genome Editing
Barry S. Coller, Annual Review of Medicine
Forensic DNA Typing
Erin Murphy, Annual Review of Criminology
Socio-Genomic Research Using Genome-Wide Molecular Data
Dalton Conley, Annual Review of Sociology
Emerging Issues in Public Health Genomics
J. Scott Roberts, Dana C. Dolinoy, and Beth A. Tarini, Annual Review of Genomics and Human Genetics
Informed Consent in Genomics and Genetic Research
Amy L. McGuire and Laura M. Beskow, Annual Review of Genomics and Human Genetics
Public Attitudes and Beliefs About Genetics
Celeste M. Condit, Annual Review of Genomics and Human Genetics
Public Concern About Genetics
Philip R. Reilly, Annual Review of Genomics and Human Genetics
DNA and Disease
Gene Editing: A New Tool for Viral Disease
Edward M. Kennedy and Bryan R. Cullen, Annual Review of Medicine
Modelling Cancer in the CRISPR Era
Andrea Ventura and Lukas E. Dow, Annual Review of Cancer Biology
Explore more about CRISPR in our special article collection: CRISPR: Editing the Genome featuring articles from innovator Jennifer A. Doudna, Nobel Laureate Shinya Yamanaka, and other award-winning scientists and pioneers in their fields.
Virus DNA Replication and the Host DNA Damage Response
Matthew D. Weitzman and Amélie Fradet-Turcotte, Annual Review of Virology
The RecQ DNA Helicases in DNA Repair
Kara A. Bernstein, Serge Gangloff, and Rodney Rothstein, Annual Review of Genetics
DNA Projects
The Genome 10K Project: A Way Forward
Klaus-Peter Koepfli, Benedict Paten, the Genome 10K Community of Scientists, and Stephen J. O'Brien, Annual Review of Animal Biosciences
The Human Genome Project and Its Impact on Psychiatry
W. Maxwell Cowan, Kathy L. Kopnisky, and Steven E. Hyman, Annual Review of Neuroscience
DNA Structure
Defining Phenotypes from Clinical Data to Derive Genomic Research
Jamie R. Robinson, Wei-Qi Wei, Dan M. Roden, and Joshua C. Denny, Annual Review of Biomedical Data Science
Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research
Yonggang Ke, Carlos Castro, and Jong Hyun Choi, Annual Review of Biomedical Engineering
Eukaryotic DNA Replication Fork
Peter M.J. Burgers and Thomas A. Kunkel, Annual Review of Biochemistry
Food Analysis Using Organelle DNA and the Effects of Processing on Assays
Jane M. Caldwell, Annual Review of Food Science and Technology
DNA-Driven Assembly: From Polyhedral Nanoparticles to Proteins
Martin Girard, Jaime A. Millan, and Monica Olvera de la Cruz, Annual Review of Materials Research
Archaeal DNA Replication
Lori M. Kelman and Zvi Kelman, Annual Review of Genetics
Annual Reviews is a nonprofit publisher dedicated to synthesizing and integrating knowledge for the progress of science and the benefit of society. We first published the Annual Review of Biochemistry in 1932 to address the persistent challenge of scientific information overload. Today we publish journals in 50 disciplines. Our Editorial Committees are leaders in their fields who invite expert authors to contribute a synthesis of scientific literature on timely topics and trends.