“In just a few short years, CRISPR/Cas9 genome editing has fundamentally changed basic, agricultural, and biomedical research, but no field has felt a more profound impact than cancer research. The ability to quickly and precisely manipulate the genome has opened the floodgates for a new and more elaborate understanding of how genes and gene regulation influence disease.” -Andrea Ventura and Lukas E. Dow

April 25 is DNA Day, founded by the US NIH National Human Genome Research Institute to commemorate the completion of the Human Genome Project in 2003 as well as the initial discovery of DNA’s double helix in 1953. In less than twenty years, genomics has changed what is possible for both health care and food security.

This curated article collection includes 18 reviews of research from pioneers and leaders on ethics, public benefits, and concerns of genomics. Interdisciplinary research on basic science and the potential of genomic projects is also highlighted.

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Annual Reviews is a nonprofit publisher dedicated to synthesizing and integrating knowledge for the progress of science and the benefit of society. We first published the Annual Review of Biochemistry in 1932 to address the persistent challenge of scientific information overload. Today we publish journals in 50 disciplines. Our Editorial Committees are leaders in their fields who invite expert authors to contribute a synthesis of scientific literature on timely topics and trends.