DNA Day - Special Article Collection

“In just a few short years, CRISPR/Cas9 genome editing has fundamentally changed basic, agricultural, and biomedical research, but no field has felt a more profound impact than cancer research. The ability to quickly and precisely manipulate the genome has opened the floodgates for a new and more elaborate understanding of how genes and gene regulation influence disease.” -Andrea Ventura and Lukas E. Dow

April 25 is DNA Day, founded by the US NIH National Human Genome Research Institute to commemorate the completion of the Human Genome Project in 2003 as well as the initial discovery of DNA’s double helix in 1953. In less than twenty years, genomics has changed what is possible for both health care and food security.

This curated article collection includes 18 reviews of research from pioneers and leaders on ethics, public benefits, and concerns of genomics. Interdisciplinary research on basic science and the potential of genomic projects is also highlighted.

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Genomics, Ethics, and Public Benefits

Ethics of Human Genome Editing

Barry S. Coller, Annual Review of Medicine

Forensic DNA Typing

Erin Murphy, Annual Review of Criminology

Socio-Genomic Research Using Genome-Wide Molecular Data

Dalton Conley, Annual Review of Sociology

Emerging Issues in Public Health Genomics

J. Scott Roberts, Dana C. Dolinoy, and Beth A. Tarini, Annual Review of Genomics and Human Genetics

Informed Consent in Genomics and Genetic Research

Amy L. McGuire and Laura M. Beskow, Annual Review of Genomics and Human Genetics

Public Attitudes and Beliefs About Genetics

Celeste M. Condit, Annual Review of Genomics and Human Genetics

Public Concerns About Genetics

Philip R. Reilly, Annual Review of Genomics and Human Genetics

DNA and Disease

Gene Editing: A New Tool for Viral Disease

Edward M. Kennedy and Bryan R. Cullen, Annual Review of Medicine

Modelling Cancer in the CRISPR Era

Andrea Ventura and Lukas E. Dow, Annual Review of Cancer Biology

Explore more about CRISPR in our special article collection: CRISPR: Editing the Genome featuring articles from innovator Jennifer A. Doudna, Nobel Laureate Shinya Yamanaka, and other award-winning scientists and pioneers in their fields.

Virus DNA Replication and the Host DNA Damage Response

Matthew D. Weitzman and Amélie Fradet-Turcotte, Annual Review of Virology

The RecQ DNA Helicases in DNA Repair

Kara A. Bernstein, Serge Gangloff, and Rodney Rothstein, Annual Review of Genetics

DNA Projects

The Genome 10K Project: A Way Forward

Klaus-Peter Koepfli, Benedict Paten, the Genome 10K Community of Scientists, and Stephen J. O'Brien, Annual Review of Animal Biosciences

The Human Genome Project and Its Impact on Psychiatry

W. Maxwell Cowan, Kathy L. Kopnisky, and Steven E. Hyman, Annual Review of Neuroscience

DNA Structure

Defining Phenotypes from Clinical Data to Derive Genomic Research

Jamie R. Robinson, Wei-Qi Wei, Dan M. Roden, and Joshua C. Denny, Annual Review of Biomedical Data Science

Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research

Yonggang Ke, Carlos Castro, and Jong Hyun Choi, Annual Review of Biomedical Engineering

Eukaryotic DNA Replication Fork

Peter M.J. Burgers and Thomas A. Kunkel, Annual Review of Biochemistry

Food Analysis Using Organelle DNA and the Effects of Processing on Assays

Jane M. Caldwell, Annual Review of Food Science and Technology

DNA-Driven Assembly: From Polyhedral Nanoparticles to Proteins

Martin Girard, Jaime A. Millan, and Monica Olvera de la Cruz, Annual Review of Materials Research

Archaeal DNA Replication

Lori M. Kelman and Zvi Kelman, Annual Review of Genetics

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Annual Reviews is a nonprofit publisher dedicated to synthesizing and integrating knowledge for the progress of science and the benefit of society. We first published the Annual Review of Biochemistry in 1932 to address the persistent challenge of scientific information overload. Today we publish journals in 50 disciplines. Our Editorial Committees are leaders in their fields who invite expert authors to contribute a synthesis of scientific literature on timely topics and trends.

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