In this special article collection on CRISPR/Cas9, innovator Jennifer A. Doudna and Nobel Laureate Shinya Yamanaka are featured among other award-winning scientists and pioneering leaders in their fields.
The discovery of the CRISPR and CRISPR-Cas adaptive immune systems has revolutionized scientists’ understanding of the human genome. These structures allow for precise manipulation of the genome, serving as tools for research into gene therapy, genetic screening, regulation, and correction. Human genome manipulation, both in vitro and in vivo, remains a topic for ethical debate and the safety and toxicity of all clinical trials and processes continue to be strictly monitored.
Read reviews written by world-renowned experts on CRISPR—from discovery to current and future applications. Perspectives on genetic engineering platforms; animal models; and the potential advantages, drawbacks, and ethical considerations of using this technology to cure human disease will inform your views of modern genetic research and gene therapies.
Last updated 06/2021
Ethics of Human Genome Editing
Barry S. Coller, Annual Review of Medicine
Models of Technology Transfer for Genome-Editing Technologies
Gregory D. Graff and Jacob S. Sherkow, Annual Review of Genomics and Human Genetics
Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science
Amr A. Abdeen, Brian D. Cosgrove, Charles A. Gersbach, and Krishanu Saha, Annual Review of Biomedical Engineering
Global Governance of Human Genome Editing: What Are the Rules?
Gary E. Marchant, Annual Review of Genomics and Human Genetics
Applications of CRISPR Technologies Across the Food Supply Chain
Katelyn Brandt and Rodolphe Barrangou, Annual Review of Food Science and Technology
Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems
Alan R. Davidson, Wang-Ting Lu, Sabrina Y. Stanley, Jingrui Wang, Marios Mejdani, Chantel N. Trost, Brian T. Hicks, Jooyoung Lee, and Erik J. Sontheimer, Annual Review of Biochemistry
CRISPR-Cas9 Structures and Mechanisms
Fuguo Jiang and Jennifer A. Doudna, Annual Review of Biophysics
Evolution and Ecology of CRISPR
Edze R. Westra, Andrea J. Dowling, Jenny M. Broniewski, and Stineke van Houte, Annual Review of Ecology, Evolution, and Systematics
CRISPR/Cas9 in Genome Editing and Beyond
Haifeng Wang, Marie La Russa, and Lei S. Qi, Annual Review of Biochemistry
CRISPR/Cas9 for Human Genome Engineering and Disease Research
Xin Xiong, Meng Chen, Wendell A. Lim, Dehua Zhao, and Lei S. Qi, Annual Review of Genomics and Human Genetics
Engineering Delivery Vehicles for Genome Editing
Christopher E. Nelson, and Charles A. Gersbach, Annual Review of Chemical and Biomolecular Engineering
Genome Editing: A New Approach to Human Therapeutics
Matthew Porteus, Annual Review of Pharmacology and Toxicology
Genome Engineering with Targetable Nucleases
Dana Carroll, Annual Review of Biochemistry
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
Rotem Sorek, C. Martin Lawrence, and Blake Wiedenheft, Annual Review of Biochemistry
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