CRISPR: Editing the Genome Special Article Collection

In this special article collection on CRISPR/Cas9, innovator Jennifer A. Doudna and Nobel Laureate Shinya Yamanaka are featured among other award-winning scientists and pioneering leaders in their fields. 

The discovery of the CRISPR and CRISPR-Cas adaptive immune systems has revolutionized scientists’ understanding of the human genome. These structures allow for precise manipulation of the genome, serving as tools for research into gene therapy, genetic screening, regulation, and correction. Human genome manipulation, both in vitro and in vivo, remains a topic for ethical debate and the safety and toxicity of all clinical trials and processes continue to be strictly monitored.

Read reviews written by world-renowned experts on CRISPR—from discovery to current and future applications. Perspectives on genetic engineering platforms; animal models; and the potential advantages, drawbacks, and ethical considerations of using this technology to cure human disease will inform your views of modern genetic research and gene therapies.

Last updated 06/2021

Ethics of Human Genome Editing

Barry S. Coller, Annual Review of Medicine

Models of Technology Transfer for Genome-Editing Technologies

Gregory D. Graff and Jacob S. Sherkow, Annual Review of Genomics and Human Genetics

Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science

Amr A. Abdeen, Brian D. Cosgrove, Charles A. Gersbach, and Krishanu Saha, Annual Review of Biomedical Engineering

Global Governance of Human Genome Editing: What Are the Rules?

Gary E. Marchant, Annual Review of Genomics and Human Genetics

Applications of CRISPR Technologies Across the Food Supply Chain

Katelyn Brandt and Rodolphe Barrangou, Annual Review of Food Science and Technology

Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems

Alan R. Davidson, Wang-Ting Lu, Sabrina Y. Stanley, Jingrui Wang, Marios Mejdani, Chantel N. Trost, Brian T. Hicks, Jooyoung Lee, and Erik J. Sontheimer, Annual Review of Biochemistry

CRISPR-Cas9 Structures and Mechanisms

Fuguo Jiang and Jennifer A. Doudna, Annual Review of Biophysics

Evolution and Ecology of CRISPR

Edze R. Westra, Andrea J. Dowling, Jenny M. Broniewski, and Stineke van Houte, Annual Review of Ecology, Evolution, and Systematics

CRISPR/Cas9 in Genome Editing and Beyond

Haifeng Wang, Marie La Russa, and Lei S. Qi, Annual Review of Biochemistry

CRISPR/Cas9 for Human Genome Engineering and Disease Research

Xin Xiong, Meng Chen, Wendell A. Lim, Dehua Zhao, and Lei S. Qi, Annual Review of Genomics and Human Genetics

Engineering Delivery Vehicles for Genome Editing

Christopher E. Nelson, and Charles A. Gersbach, Annual Review of Chemical and Biomolecular Engineering

Genome Editing: A New Approach to Human Therapeutics

Matthew Porteus, Annual Review of Pharmacology and Toxicology

Genome Engineering with Targetable Nucleases

Dana Carroll, Annual Review of Biochemistry

CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

Rotem Sorek, C. Martin Lawrence, and Blake Wiedenheft, Annual Review of Biochemistry

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