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Annual Review of Pathology: Mechanisms of Disease

Volume 13, 2018

Desmosomes in Human Disease

Abstract

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.

Keyword(s): armadillo proteins, desmosomal cadherins, desmosomal diseases, plakin proteins
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2018-01-24
2024-04-18
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Desmosomes in Human Disease
Annual Review of Pathology: Mechanisms of Disease 13, 51 (2018); https://doi.org/10.1146/annurev-pathol-020117-044030
/content/journals/10.1146/annurev-pathol-020117-044030
/content/journals/10.1146/annurev-pathol-020117-044030
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