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Annual Review of Biochemistry

Volume 92, 2023

mRNA Regulation by RNA Modifications

  • Wendy V. Gilbert1 and Sigrid Nachtergaele2
  • 1Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, USA; email: [email protected] 2Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA; email: [email protected]
  • Vol. 92:175-198 (Volume publication date June 2023)
  • First published as a Review in Advance on April 05, 2023
  • Copyright © 2023 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information

Abstract

Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript synthesis in the nucleus through to their decay in the cytoplasm, but in many cases, the molecular mechanisms involved in these processes remain mysterious. Here, we highlight recent work that has elucidated the roles of mRNA modifications throughout the mRNA life cycle, describe gaps in our understanding and remaining open questions, and offer some forward-looking perspective on future directions in the field.

Keyword(s): epitranscriptome, posttranscriptional regulation, RNA metabolism, RNA modifications
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mRNA Regulation by RNA Modifications
Annual Review of Biochemistry 92, 175 (2023); https://doi.org/10.1146/annurev-biochem-052521-035949
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