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Annual Review of Biochemistry

Volume 85, 2016

The Substrate Specificity of Sirtuins

Abstract

Sirtuins are NAD+-dependent enzymes universally present in all organisms, where they play central roles in regulating numerous biological processes. Although early studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD+, more recent studies have revealed that these enzymes can remove a variety of acyl-lysine modifications. The specificities for varied acyl modifications may thus underlie the distinct roles of the different sirtuins within a given organism. This review summarizes the structure, chemistry, and substrate specificity of sirtuins with a focus on how different sirtuins recognize distinct substrates and thus carry out specific functions.

Keyword(s): ADP-ribosylation, deacylation, myristoylation, palmitoylation, succinylation
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2016-06-02
2025-06-15
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The Substrate Specificity of Sirtuins
Annual Review of Biochemistry 85, 405 (2016); https://doi.org/10.1146/annurev-biochem-060815-014537
/content/journals/10.1146/annurev-biochem-060815-014537
/content/journals/10.1146/annurev-biochem-060815-014537
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