DNA Fragility and Repair: Some Personal Recollections

Literature Cited

1. 1.

   Lindahl T. 1982. DNA repair enzymes. Annu. Rev. Biochem. 51:61–87
   [Google Scholar]
2. 2.

   Lindahl T. 1974. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues. PNAS 71:3649–53
   [Google Scholar]
3. 3.

   Lindahl T. 1993. Instability and decay of the primary structure of DNA. Nature 362:709–15
   [Google Scholar]
4. 4.

   Friedberg EC. 1997. Correcting the Blueprint of Life. An Historical Account of the Discovery of DNA Repair Mechanisms Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
   [Google Scholar]
5. 5.

   Strauss BS. 2018. Why is DNA double stranded? The discovery of DNA excision repair mechanisms. Genetics 209:357–66
   [Google Scholar]
6. 6.

   Barnes DE, Lindahl T. 2004. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu. Rev. Genet. 38:445–76
   [Google Scholar]
7. 7.

   Dianov GL, Hübscher U. 2013. Mammalian base excision repair: the forgotten archangel. Nucleic Acids Res. 41:3483–90
   [Google Scholar]
8. 8.

   Lindahl T. 2015. The intrinsic fragility of DNA. The Nobel Prizes 2015 K Grandin 73–84. Sagamore Beach, MA: Science History Publications/USA
   [Google Scholar]
9. 9.

   Friedberg EC, Elledge SJ, Lehmann AR, Lindahl T, Muzi-Falconi M, eds. 2014. DNA Repair, Mutagenesis and Other Responses to DNA Damage Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
   [Google Scholar]
10. 10.

    Slupphaug G, Krokan HE, eds. 2018. Genomic Uracil, Evolution, Biology, Immunology and Disease Singapore: World Scientific Publishing Co.
    [Google Scholar]
11. 11.

    Weston KM. 2014. Country life – repair and replication. Blue Skies and Bench Space. Adventures in Cancer Research81–121. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
    [Google Scholar]
12. 12.

    Tubbs A, Nussenzweig A. 2017. Endogenous DNA damage as a source of genomic instability in cancer. Cell 168:644–56
    [Google Scholar]
13. 13.

    Weeks ME, Larson ME. 1937. JA Arfwedson and his services to chemistry. J. Chem. Edu. 14:403–7
    [Google Scholar]
14. 14.

    Wood RD, Robins P, Lindahl T. 1988. Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell 53:97–106
    [Google Scholar]
15. 15.

    Wood RD, Mitchell M, Sgouros J, Lindahl T. 2001. Human DNA repair genes. Science 291:1284–89
    [Google Scholar]
16. 16.

    Wood RD, Lowery M. 2020. Human DNA repair genes. Wood Laboratory https://www.mdanderson.org/documents/Labs/Wood-Laboratory/human-dna-repair-genes.html
    [Google Scholar]
17. 17.

    Olsson M, Lindahl T. 1980. Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O⁶-methylguanine to a protein cysteine residue. J. Biol. Chem. 255:10569–71
    [Google Scholar]
18. 18.

    Teo I, Sedgwick B, Kilpatrick MW, McCarthy TV, Lindahl T. 1986. The intracellular signal for induction of resistance to alkylating agents in E. coli. Cell 45:315–24
    [Google Scholar]
19. 19.

    Lindahl T. 2016. The world of DNA in glycol solution. Nat. Rev. Mol. Cell Biol. 17:335–36
    [Google Scholar]
20. 20.

    Hoeijmakers JH. 2009. DNA damage, aging, and cancer. N. Engl. J. Med. 361:1475–85
    [Google Scholar]
21. 21.

    Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. 2018. Nuclear genomic instability and aging. Annu. Rev. Biochem. 87:295–322
    [Google Scholar]
22. 22.

    Al Zouabi L, Bardin AJ 2020. Stem cell DNA damage and genome mutation in the context of aging and cancer initiation. Cold Spring Harb. Perspect. Biol. 12:a036210
    [Google Scholar]
23. 23.

    Abascal F, Harvey LMR, Mitchell E, Lawson ARJ, Lensing SV et al. 2021. Somatic mutation landscapes at single-molecule resolution. Nature 593:405–10
    [Google Scholar]
24. 24.

    Cagan A, Baez-Ortega A, Brzozowska N, Abascal F, Coorens THH et al. 2022. Somatic mutation rates scale with lifespan across mammals. Nature 604:517–24
    [Google Scholar]
25. 25.

    Cleaver JE. 1968. Defective repair replication of DNA in xeroderma pigmentosum. Nature 218:652–56
    [Google Scholar]
26. 26.

    Rydberg B, Lindahl T. 1982. Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction. EMBO J. 1:211–16
    [Google Scholar]
27. 27.

    Sedgwick B, Bates PA, Paik J, Jacobs SC, Lindahl T. 2007. Repair of alkylated DNA: recent advances. DNA Repair. 6:429–42
    [Google Scholar]
28. 28.

    Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R et al. 2015. Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen. Mol. Cell 60:177–88
    [Google Scholar]
29. 29.

    Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S et al. 2018. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature 553:171–77
    [Google Scholar]
30. 30.

    Xia J, Chiu LY, Nehring RB, Bravo Núñez MA, Mei Q et al. 2019. Bacteria-to-human protein networks reveal origins of endogenous DNA damage. Cell 176:127–43
    [Google Scholar]
31. 31.

    Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B. 2002. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419:174–78
    [Google Scholar]
32. 32.

    Falnes PØ, Johansen RF, Seeberg E. 2002. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419:178–82
    [Google Scholar]
33. 33.

    Jia G, Fu Y, Zhao X, Dai Q, Zheng G et al. 2011. N⁶-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7:885–87
    [Google Scholar]
34. 34.

    Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:1748–55
    [Google Scholar]
35. 35.

    Truini A, Germano G, Bardelli A. 2018. Inactivation of DNA repair prospects for boosting cancer immune surveillance. Genome Med. 10:91–93
    [Google Scholar]
36. 36.

    Lindahl T, Adams A, Bjursell G, Bornkamm GW, Kaschka-Dierich C, Jehn U. 1976. Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line. J. Mol. Biol. 102:511–30
    [Google Scholar]
37. 37.

    Kaschka-Dierich C, Adams A, Lindahl T, Bornkamm GW, Bjursell G et al. 1976. Intracellular forms of Epstein-Barr virus DNA in human tumour cells in vivo. Nature 260:302–6
    [Google Scholar]
38. 38.

    Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ et al. 2022. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science 375:296–301
    [Google Scholar]
39. 39.

    Yang YG, Lindahl T, Barnes DE. 2007. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131:873–86
    [Google Scholar]
40. 40.

    Lindahl T, Barnes DE, Yang YG, Robins P. 2009. Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem. Soc. Trans. 37:Part 3535–38
    [Google Scholar]
41. 41.

    Prasad R, Longley MJ, Sharief FS, Hou EW, Copeland WC, Wilson SH. 2009. Human DNA polymerase theta possesses 5′-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic Acids Res. 37:1868–77
    [Google Scholar]
42. 42.

    Satoh MS, Lindahl T. 1992. Role of poly(ADP-ribose) formation in DNA repair. Nature 356:356–58
    [Google Scholar]