Older adults with subjective cognitive decline (SCD) in the absence of objective neuropsychological dysfunction are increasingly viewed as at risk for non-normative cognitive decline and eventual progression to Alzheimer's disease (AD) dementia. The past decade has witnessed tremendous growth in research on SCD, which may reflect the recognition of SCD as the earliest symptomatic manifestation of AD. Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct. This article reviews essential features of SCD associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings. We consider the relation of SCD to important variables and outcomes (e.g., AD biomarkers, clinical progression). We also examine the role of self- and informant-reports in SCD and various psychological, medical, and demographic factors that influence the self-report of cognition. We conclude with a discussion of intervention strategies for SCD, ethical considerations, and future research priorities.


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Literature Cited

  1. Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JJ. et al. 2016. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. Int. Psychogeriatr. 29:645–52 [Google Scholar]
  2. Allan CL, Sexton CE, Filippini N, Topiwala A, Mahmood A. et al. 2016. Sub-threshold depressive symptoms and brain structure: a magnetic resonance imaging study within the Whitehall II cohort. J. Affect. Disord. 204:219–25 [Google Scholar]
  3. Allaz A-F, Cedraschi C. 2015. Emotional aspects of chronic pain. Pain, Emotion and Cognition: A Complex Nexus G Pickering, S Gibson 21–34 New York: Springer, 1st ed.. [Google Scholar]
  4. Alzheimer's Assoc. 2016a. Prevalence Chicago: Alzheimer's Assoc http://www.alz.org/facts/#prevalence [Google Scholar]
  5. Alzheimer's Assoc. 2016b. Risk Factors Chicago: Alzheimer's Assoc http://www.alz.org/alzheimers_disease_causes_risk_factors.asp [Google Scholar]
  6. Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N. et al. 2012. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia 50:2880–86 [Google Scholar]
  7. Amariglio RE, Donohue MC, Marshall GA, Rentz DM, Salmon DP. et al. 2015a. Tracking early decline in cognitive function in older individuals at risk for Alzheimer's disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument. JAMA Neurol 72:446–54 [Google Scholar]
  8. Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P. et al. 2015b. Subjective cognitive concerns, amyloid-beta, and neurodegeneration in clinically normal elderly. Neurology 85:56–62 [Google Scholar]
  9. Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM. 2011. Specific subjective memory complaints in older persons may indicate poor cognitive function. J. Am. Geriatr. Soc. 59:1612–17 [Google Scholar]
  10. Antonell A, Fortea J, Rami L, Bosch B, Balasa M. et al. 2011. Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaints. J. Neural Transm. 118:259–62 [Google Scholar]
  11. Attix DK, Welsh-Bohmer KA. 2013. Geriatric Neuropsychology: Assessment and Intervention New York: Guilford [Google Scholar]
  12. Bartley M, Bokde AL, Ewers M, Faluyi YO, Tobin WO. et al. 2012. Subjective memory complaints in community dwelling healthy older people: the influence of brain and psychopathology. Int. J. Geriatr. Psychiatry 27:836–43 [Google Scholar]
  13. Bechara A. 2007. Iowa Gambling Task Lutz, FL: Psychol. Assess. Resour. [Google Scholar]
  14. Boone KB. 2009. Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?. Clin. Neuropsychol. 23:1016–36 [Google Scholar]
  15. Bourne VJ, Fox HC, Starr JM, Deary IJ, Whalley LJ. 2007. Social support in later life: examining the roles of childhood and adulthood cognition. Pers. Individ. Differ. 43:937–48 [Google Scholar]
  16. Bridle C, Spanjers K, Patel S, Atherton NM, Lamb SE. 2012. Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials. Br. J. Psychiatry 201:180–85 [Google Scholar]
  17. Buckley RF, Ellis KA, Ames D, Rowe CC, Lautenschlager NT. et al. 2015a. Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology 29:571–81 [Google Scholar]
  18. Buckley RF, Maruff P, Ames D, Bourgeat P, Martins RN. et al. 2016a. Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimers Dement 12:7796–804 [Google Scholar]
  19. Buckley R, Saling MM, Ames D, Rowe CC, Lautenschlager NT. et al. 2013. Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. Int. Psychogeriatr. 25:1307–15 [Google Scholar]
  20. Buckley R, Saling M, Ellis K, Rowe C, Maruff P. et al. 2015b. Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age Ageing 44:1012–19 [Google Scholar]
  21. Buckley RF, Saling MM, Fromann I, Wolfsgruber S, Wagner M. 2015c. Subjective cognitive decline from a phenomenological perspective: a review of the qualitative literature. J. Alzheimers Dis. 48:Supp. 125–40 [Google Scholar]
  22. Buckley RF, Villemagne VL, Masters CL, Ellis K, Rowe C. et al. 2016b. Conceptualization of the utility of subjective cognitive decline in clinical trials of preclinical Alzheimer's disease. J. Mol. Neurosci. 60:3354–61 [Google Scholar]
  23. Butters MA, Young JB, Lopez O, Aizenstein HJ, Mulsant BH. et al. 2008. Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin. Neurosci. 10:345–57 [Google Scholar]
  24. Cargin JW, Collie A, Masters C, Maruff P. 2008. The nature of cognitive complaints in healthy older adults with and without objective memory decline. J. Clin. Exp. Neuropsychol. 30:245–57 [Google Scholar]
  25. Carr DB, Gray S, Baty J. 2000. The value of informant versus individual's complaints of memory impairment in early dementia. Neurology 55:1724–26 [Google Scholar]
  26. Caselli RJ, Chen K, Locke DE, Lee W, Roontiva A. et al. 2014. Subjective cognitive decline: self and informant comparisons. Alzheimers Dement 10:93–98 [Google Scholar]
  27. Chetelat G, Villemagne VL, Bourgeat P, Pike KE, Jones G. et al. 2010. Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Ann. Neurol. 67:317–24 [Google Scholar]
  28. Choi J, Twamley EW. 2013. Cognitive rehabilitation therapies for Alzheimer's disease: a review of methods to improve treatment engagement and self-efficacy. Neuropsychol. Rev. 23:48–62 [Google Scholar]
  29. Chung JC, Man DW. 2009. Self-appraised, informant-reported, and objective memory and cognitive function in mild cognitive impairment. Dement. Geriatr. Cogn. Disord. 27:187–93 [Google Scholar]
  30. Colijn MA, Grossberg GT. 2015. Amyloid and tau biomarkers in subjective cognitive impairment. J. Alzheimers Dis. 47:1–8 [Google Scholar]
  31. Cooper C, Bebbington P, Lindesay J, Meltzer H, McManus S. et al. 2011. The meaning of reporting forgetfulness: a cross-sectional study of adults in the English 2007 Adult Psychiatric Morbidity Survey. Age Ageing 40:711–17 [Google Scholar]
  32. Costa PT Jr., McCrae RR. 1994. Set like plaster: evidence for the stability of adult personality. Can Personality Change? ed. TF Heatherton, JL Weinberger 21–40 Washington, DC: Am. Psychol. Assoc. [Google Scholar]
  33. DaSilva J, Gonçalves-Pereira M, Xavier M, Mukaetova-Ladinska EB. 2013. Affective disorders and risk of developing dementia: systematic review. Br. J. Psychiatry 202:177–86 [Google Scholar]
  34. Dik MG, Jonker C, Comijs HC, Bouter LM, Twisk JW. et al. 2001. Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly. Neurology 57:2217–22 [Google Scholar]
  35. Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF. 2013. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br. J. Psychiatry 202:329–35 [Google Scholar]
  36. Draper B, Peisah C, Snowdon J, Brodaty H. 2010. Early dementia diagnosis and the risk of suicide and euthanasia. Alzheimers Dement 6:75–82 [Google Scholar]
  37. Duberstein PR, Chapman BP, Tindle HA, Sink KM, Bamonti P. et al. 2011. Personality and risk for Alzheimer's disease in adults 72 years of age and older: a six-year follow-up. Psychol. Aging 26:351–62 [Google Scholar]
  38. Dufouil C, Fuhrer R, Alperovitch A. 2005. Subjective cognitive complaints and cognitive decline: consequence or predictor? The epidemiology of vascular aging study. J. Am. Geriatr. Soc. 53:616–21 [Google Scholar]
  39. Fox C, Lafortune L, Boustani M, Brayne C. 2013. Debate & analysis: the pros and cons of early diagnosis in dementia. Br. J. Gen. Pract. 63:612e510–12 [Google Scholar]
  40. Fratiglioni L, Paillard-Borg S, Winblad B. 2004. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3:343–53 [Google Scholar]
  41. Friedman HS, Kern ML, Hampson SE, Duckworth AL. 2014. A new life-span approach to conscientiousness and health: combining the pieces of the causal puzzle. Dev. Psychol. 50:1377–89 [Google Scholar]
  42. Geerlings MI, Jonker C, Bouter LM, Ader HJ, Schmand B. 1999. Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. Am. J. Psychiatry 156:531–37 [Google Scholar]
  43. Gibson SJ. 2015. The pain, emotion, and cognition nexus in older persons and in dementia. Pain, Emotion and Cognition: A Complex Nexus G Pickering, S Gibson 231–47 New York: Springer [Google Scholar]
  44. Gifford KA, Liu D, Carmona H, Lu Z, Romano R. et al. 2015a. Inclusion of an informant yields strong associations between cognitive complaint and longitudinal cognitive outcomes in non-demented elders. J. Alzheimers Dis. 43:121–32 [Google Scholar]
  45. Gifford KA, Liu D, Lu Z, Tripodis Y, Cantwell NG. et al. 2014. The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults. Alzheimers Dement 10:319–27 [Google Scholar]
  46. Gifford KA, Liu D, Romano RR, Jones RN, Jefferson AL. 2015b. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement. Diagn. Assess. Dis. Monit. 1:429–39 [Google Scholar]
  47. Goesling J, Clauw DJ, Hassett AL. 2013. Pain and depression: an integrative review of neurobiological and psychological factors. Curr. Psychiatry Rep. 15:421 [Google Scholar]
  48. Hall J, Kellett S, Berrios RE, Bains MK, Scott S. 2016. Efficacy of cognitive behavioral therapy for generalized anxiety disorder in older adults: systematic review, meta-analysis, and meta-regression. Am. J. Geriatr. Psychiatry 24:111063–73 [Google Scholar]
  49. Harwood DG, Barker WW, Ownby RL, Mullan M, Duara R. 2004. No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly. Int. J. Geriatr. Psychiatry 19:1131–39 [Google Scholar]
  50. Hertzog C, Pearman A. 2014. Memory complaints in adulthood and old age. The SAGE Handbook of Applied Memory TJ Perfect, DS Lindsay 423–43 London: SAGE [Google Scholar]
  51. Hill NL, Mogle JM, Munoz E, Wion R, Colancecco EM. 2015. Assessment of subjective cognitive impairment among older adults. J. Gerontol. Nurs. 41:28–35 [Google Scholar]
  52. Hohman TJ, Beason-Held LL, Lamar M, Resnick SM. 2011. Subjective cognitive complaints and longitudinal changes in memory and brain function. Neuropsychology 25:125–30 [Google Scholar]
  53. Huckans M, Hutson L, Twamley E, Jak A, Kaye J, Storzbach D. 2013. Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions. Neuropsychol. Rev. 23:68–80 [Google Scholar]
  54. Jack CR, Wiste HJ, Vemuri P, Weigand SD, Senjem ML. et al. 2010. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease. Brain 133:3336–48 [Google Scholar]
  55. Jackson J, Balota DA, Head D. 2011. Exploring the relationship between personality and regional brain volume in healthy aging. Neurobiol. Aging 32:2162–71 [Google Scholar]
  56. Jackson JD, Rentz DM, Aghjayan S, Buckley RF, Meneide TF. et al. 2016. Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons. Alzheimers Dement 12:7 Suppl.P1173 [Google Scholar]
  57. Jenkins A, Tales A, Tree J, Bayer A. 2015. Are we ready? The construct of subjective cognitive impairment and its utilization in clinical practice: a preliminary UK-based service evaluation. J. Alzheimers Dis. 48:S25–31 [Google Scholar]
  58. Jessen F. 2014. Subjective and objective cognitive decline at the pre-dementia stage of Alzheimer's disease. Eur. Arch. Psychiatry Clin. Neurosci. 264:Suppl. 1S3–7 [Google Scholar]
  59. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M. et al. 2014a. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement 10:844–52 [Google Scholar]
  60. Jessen F, Feyen L, Freymann K, Tepest R, Maier W. et al. 2006. Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiol. Aging 27:1751–56 [Google Scholar]
  61. Jessen F, Wiese B, Bachmann C, Eifflaender-Gorfer S, Haller F. et al. 2010. Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. Arch. Gen. Psychiatry 67:414–22 [Google Scholar]
  62. Jessen F, Wolfsgruber S, Wiese B, Bickel H, Mösch E. et al. 2014b. AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimers Dement 10:76–83 [Google Scholar]
  63. Jonker C, Geerlings MI, Schmand B. 2000. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int. J. Geriatr. Psychiatry 15:983–91 [Google Scholar]
  64. Jorm AF, Christensen H, Henderson AS, Korten AE, Mackinnon AJ, Scott R. 1994. Complaints of cognitive decline in the elderly: a comparison of reports by subjects and informants in a community survey. Psychol. Med. 24:365–74 [Google Scholar]
  65. Joshi YB, Pratico D. 2013. Stress and HPA axis dysfunction in Alzheimer's disease. Studies on Alzheimer's Disease D Pratico, P Mecocci 159–65 New York: Springer [Google Scholar]
  66. Kapogiannis D, Sutin A, Davatzikos C, Costa P Jr., Resnick S. 2013. The five factors of personality and regional cortical variability in the Baltimore longitudinal study of aging. Hum. Brain Mapp. 34:2829–40 [Google Scholar]
  67. Kaup AR, Nettiksimmons J, LeBlanc ES, Yaffe K. 2015. Memory complaints and risk of cognitive impairment after nearly 2 decades among older women. Neurology 85:1852–58 [Google Scholar]
  68. Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G. et al. 2004. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55:306–19 [Google Scholar]
  69. Koppara A, Frommann I, Polcher A, Parra MA, Maier W. et al. 2015a. Feature binding deficits in subjective cognitive decline and in mild cognitive impairment. J. Alzheimers Dis. 48:Suppl. 1S161–70 [Google Scholar]
  70. Koppara A, Wagner M, Lange C, Ernst A, Wiese B. et al. 2015b. Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimers Dement 1:194–205 [Google Scholar]
  71. Krell-Roesch J, Woodruff BK, Acosta JI, Locke DE, Hentz JG. et al. 2015. APOE epsilon4 genotype and the risk for subjective cognitive impairment in elderly persons. J. Neuropsychiatry Clin. Neurosci. 27:322–25 [Google Scholar]
  72. Kremen WS, Lachman ME, Pruessner JC, Sliwinski M, Wilson RS. 2012. Mechanisms of age-related cognitive change and targets for intervention: social interactions and stress. J. Gerontol. A Biol. Sci. Med. Sci 67:760–65 [Google Scholar]
  73. Lautenschlager NT, Flicker L, Vasikaran S, Leedman P, Almeida OP. 2005. Subjective memory complaints with and without objective memory impairment: relationship with risk factors for dementia. Am. J. Geriatr. Psychiatry 13:731–34 [Google Scholar]
  74. Laws SM, Clarnette RM, Taddei K, Martins G, Paton A. et al. 2002. APOE-epsilon4 and APOE-491A polymorphisms in individuals with subjective memory loss. Mol. Psychiatry 7:768–75 [Google Scholar]
  75. Lineweaver TT, Bondi MW, Galasko D, Salmon DP. 2014. Effect of knowledge of APOE genotype on subjective and objective memory performance in healthy older adults. Am. J. Psychiatry 171:201–8 [Google Scholar]
  76. Low LF, Harrison F, Lackersteen SM. 2013. Does personality affect risk for dementia? A systematic review and meta-analysis. Am. J. Geriatr. Psychiatry 21:713–28 [Google Scholar]
  77. Mackinnon A, Mulligan R. 1998. Combining cognitive testing and informant report to increase accuracy in screening for dementia. Am. J. Psychiatry 155:1529–35 [Google Scholar]
  78. Makris UE, Abrams RC, Gurland B, Carrington Reid M. 2014. Management of persistent pain in the older patient: a clinical review. JAMA 312:825–37 [Google Scholar]
  79. Marini S, Bagnoli S, Bessi V, Tedde A, Bracco L. et al. 2011. Implication of serotonin-transporter (5-HTT) gene polymorphism in subjective memory complaints and mild cognitive impairment (MCI). Arch. Gerontol. Geriatr. 52:e71–74 [Google Scholar]
  80. McConnell H. 2014. Laboratory testing in neuropsychology. Clinical Neuropsychology: A Pocket Handbook for Assessment MW Parsons, TA Hammeke, PJ Snyder 53–73 Washington, DC: Am. Psychol. Assoc, 3rd ed.. [Google Scholar]
  81. Meiberth D, Scheef L, Wolfsgruber S, Boecker H, Block W. et al. 2015. Cortical thinning in individuals with subjective memory impairment. J. Alzheimers Dis. 45:139–46 [Google Scholar]
  82. Mitrushina M, Boone KB, Razani J, D'Elia LF. 2005. Handbook of Normative Data for Neuropsychological Assessment New York: Oxford Univ. Press [Google Scholar]
  83. Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B. et al. 2017. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement 13:296–311 [Google Scholar]
  84. Mosconi L, De Santi S, Brys M, Tsui WH, Pirraglia E. et al. 2008. Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints. Biol. Psychiatry 63:609–18 [Google Scholar]
  85. Mulligan BP, Smart CM, Ali JI. 2016. Relationship between subjective and objective performance indicators in subjective cognitive decline. Psychol. Neurosci. 9:362–78 [Google Scholar]
  86. Nunes T, Fragata I, Ribeiro F, Palma T, Maroco J. et al. 2010. The outcome of elderly patients with cognitive complaints but normal neuropsychological tests. J. Alzheimers Dis. 19:137–45 [Google Scholar]
  87. Parisi JM, Gross AL, Rebok GW, Saczynski JS, Crowe M. et al. 2011. Modeling change in memory performance and memory perceptions: findings from the ACTIVE study. Psychol. Aging 26:518–24 [Google Scholar]
  88. Park J, Hughes AK. 2012. Nonpharmacological approaches to the management of chronic pain in community-dwelling older adults: a review of empirical evidence. J. Am. Geriatr. Soc. 60:555–68 [Google Scholar]
  89. Peckham AD, McHugh RK, Otto MW. 2010. A meta-analysis of the magnitude of biased attention in depression. Depress. Anxiety 27:1135–42 [Google Scholar]
  90. Perrotin A, de Flores R, Lamberton F, Poisnel G, La Joie R. et al. 2015. Hippocampal subfield volumetry and 3D surface mapping in subjective cognitive decline. J. Alzheimers Dis. 48:Suppl. 1S141–50 [Google Scholar]
  91. Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ. 2012. Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals. Arch. Neurol. 69:223–29 [Google Scholar]
  92. Peter J, Scheef L, Abdulkadir A, Boecker H, Heneka M. et al. 2014. Gray matter atrophy pattern in elderly with subjective memory impairment. Alzheimers Dement 10:99–108 [Google Scholar]
  93. Pietrzak RH, Lim YY, Ames D, Harrington K, Restrepo C. et al. 2015a. Trajectories of memory decline in preclinical Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of ageing. Neurobiol. Aging 36:1231–38 [Google Scholar]
  94. Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA. et al. 2015b. Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease. JAMA Psychiatry 72:284–91 [Google Scholar]
  95. Popp J, Wolfsgruber S, Heuser I, Peters O, Hull M. et al. 2015. Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type. Neurobiol. Aging 36:601–7 [Google Scholar]
  96. Puente AE, Puente AN. 2013. Assessment of neuropsychological functioning. APA Handbook of Testing and Assessment in Psychology, Vol. 2: Testing and Assessment in Clinical and Counseling Psychology KF Geisinger 133–52 Washington, DC: Am. Psychol. Assoc. [Google Scholar]
  97. Rabin LA, Chi SY, Wang C, Fogel J, Kann SJ, Aronov A. 2014. Prospective memory on a novel clinical task in older adults with mild cognitive impairment and subjective cognitive decline. Neuropsychol. Rehabil. 24:863–93 [Google Scholar]
  98. Rabin LA, Saykin A, Brown M, Wishart H, Flashman L. et al. 2010. Complaints associated with current cognitive functioning and progression to dementia: predictive value of patient and informant report items Presented at Midyear Meet. Int. Neuropsychol. Soc. Krakow, Poland: [Google Scholar]
  99. Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman L. et al. 2015. Subjective cognitive decline in older adults: an overview of self-report measures used across 19 international research studies. J. Alzheimers Dis. 48:Suppl. 1S63–86 [Google Scholar]
  100. Rabin LA, Wang C, Katz MJ, Derby CA, Buschke H, Lipton RB. 2012. Predicting Alzheimer's disease: neuropsychological tests, self-reports, and informant reports of cognitive difficulties. J. Am. Geriatr. Soc. 60:1128–34 [Google Scholar]
  101. Rami L, Mollica MA, Garcia-Sanchez C, Molinuevo JL. 2014. The Subjective Cognitive Decline Questionnaire (SCD-Q): a validation study. J. Alzheimers Dis. 41:453–66 [Google Scholar]
  102. Rattanabannakit C, Risacher SL, Gao S, Lane K, Brown SA. et al. 2016. The Cognitive Change Index as a measure of self and informant perception of cognitive decline: relation to neuropsychological tests. J. Alzheimers Dis. 51:1145–55 [Google Scholar]
  103. Reid MC, Eccleston C, Pillemer K. 2015. Management of chronic pain in older adults. BMJ 350:1–10 [Google Scholar]
  104. Reisberg B. 1986. Dementia: a systematic approach to identifying reversible causes. Geriatrics 41:30–46 [Google Scholar]
  105. Reisberg B, Ferris SH, de Leon MJ, Crook T. 1982. The Global Deterioration Scale for assessment of primary degenerative dementia. Am. J. Psychiatry 139:1136–39 [Google Scholar]
  106. Reisberg B, Gauthier S. 2008. Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. Int. Psychogeriatr. 20:1–16 [Google Scholar]
  107. Reisberg B, Prichep L, Mosconi L, John R, Glodzik-Sobanska L. et al. 2008. The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. Alzheimers Dement 4:S98–108 [Google Scholar]
  108. Reisberg B, Shulman MB, Torossian C, Leng L, Zhu W. 2010. Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimers Dement 6:11–24 [Google Scholar]
  109. Rentz DM, Parra Rodriguez MA, Amariglio R, Stern Y, Sperling R, Ferris S. 2013. Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease: a selective review. Alzheimers Res. Ther. 5:58 [Google Scholar]
  110. Risacher SL, Kim S, Nho K, Foroud T, Shen L. et al. 2015. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimers Dement 11:1417–29 [Google Scholar]
  111. Roberts B, Mroczek D. 2008. Personality trait change in adulthood. Curr. Dir. Psychol. Sci. 17:31–35 [Google Scholar]
  112. Roberts JL, Clare L, Woods RT. 2009. Subjective memory complaints and awareness of memory functioning in mild cognitive impairment: a systematic review. Dement. Geriatr. Cogn. Disord. 28:95–109 [Google Scholar]
  113. Rodda J, Okello A, Edison P, Dannhauser T, Brooks DJ, Walker Z. 2010. (11)C-PIB PET in subjective cognitive impairment. Eur. Psychiatry 25:123–25 [Google Scholar]
  114. Rodriguez-Gomez O, Abdelnour C, Jessen F, Valero S, Boada M. 2015. Influence of sampling and recruitment methods in studies of subjective cognitive decline. J. Alzheimers Dis. 48:Suppl. 1S99–107 [Google Scholar]
  115. Rowe CC, Ellis KA, Rimajova M, Bourgeat P, Pike KE. et al. 2010. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiol. Aging 31:1275–83 [Google Scholar]
  116. Rueda AD, Lau KM, Saito N, Harvey D, Risacher SL. et al. 2015. Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. Alzheimers Dement 11:1080–89 [Google Scholar]
  117. Sahathevan R, Brodtmann A, Donnan GA. 2011. Dementia, stroke, and vascular risk factors: a review. Int. J. Stroke 7:61–73 [Google Scholar]
  118. Samieri C, Proust-Lima C, Glymour MM, Okereke OI, Amariglio RE. et al. 2014. Subjective cognitive concerns, episodic memory, and the APOE epsilon4 allele. Alzheimers Dement 10:752–59e1 [Google Scholar]
  119. Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA. et al. 2006. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 67:834–42 [Google Scholar]
  120. Scheef L, Spottke A, Daerr M, Joe A, Striepens N. et al. 2012. Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology 79:1332–39 [Google Scholar]
  121. Schicktanz S, Schweda M, Ballenger JF, Fox PJ, Halpern J. et al. 2014. Before it is too late: professional responsibilities in late-onset Alzheimer's research and pre-symptomatic prediction. Front. Hum. Neurosci. 8:921 https://doi.org/10.3389/fnhum.2014.00921 [Google Scholar]
  122. Schmand B, Jonker C, Hooijer C, Lindeboom J. 1996. Subjective memory complaints may announce dementia. Neurology 46:121–25 [Google Scholar]
  123. Schofield PW, Marder K, Dooneief G, Jacobs DM, Sano M, Stern Y. 1997. Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. Am. J. Psychiatry 154:609–15 [Google Scholar]
  124. Scott SB, Graham-Engeland JE, Engeland CG, Smyth JM, Almeida DM. et al. 2015. The Effects of Stress on Cognitive Aging, Physiology and Emotion (ESCAPE) project. BMC Psychiatry 15:146 [Google Scholar]
  125. Sexton CE, McKay CE, Ebmeier KP. 2013. A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Am. J. Geriatr. Psychiatry 21:184–95 [Google Scholar]
  126. Sikkes SAM, Rabin LA, Crane PK. 2015. Harmonization of international subjective cognitive decline (SCD) questionnaires: Which cognitive complaints relate to clinical outcomes. Alzheimers Dement 11:Suppl. 7307–8 [Google Scholar]
  127. Simon SS, Cordás TA, Bottino CMC. 2014. Cognitive behavioral therapies in older adults with depression and cognitive deficits: a systematic review. Int. J. Geriatr. Psychiatry 30:223–33 [Google Scholar]
  128. Slavin MJ, Brodaty H, Kochan NA, Crawford JD, Trollor JN. et al. 2010. Prevalence and predictors of “subjective cognitive complaints” in the Sydney Memory and Ageing Study. Am. J. Geriatr. Psychiatry 18:701–10 [Google Scholar]
  129. Smart CM, Karr JE, Areshenkoff CN, Rabin LA, Hudon CA. et al. 2017. Non-pharmacologic interventions for older adults with subjective cognitive decline: systematic review, meta-analysis, and preliminary recommendations. Neuropsychol. Rev. https://doi.org/10.1007/s11065-017-9342-8 [Google Scholar]
  130. Smart CM, Koudys J, Mulligan BP. 2015. Examining conscientiousness in older adults with subjective cognitive decline: Are we really measuring personality. Alzheimers Dement 11:Suppl. 7583 [Google Scholar]
  131. Smart CM, Krawitz A. 2015. The impact of subjective cognitive decline on Iowa Gambling Task performance. Neuropsychology 29:971–87 [Google Scholar]
  132. Smart CM, Segalowitz SJ, Mulligan BP, Koudys J, Gawryluk J. 2016. Mindfulness training for older adults with subjective cognitive decline: results from a pilot randomized controlled trial. J. Alzheimers Dis. 52:757–74 [Google Scholar]
  133. Smart CM, Segalowitz SJ, Mulligan BP, MacDonald SW. 2014. Attention capacity and self-report of subjective cognitive decline: a P300 ERP study. Biol. Psychol. 103:144–51 [Google Scholar]
  134. Snitz BE, Lopez OL, McDade E, Becker JT, Cohen AD. et al. 2015a. Amyloid-beta imaging in older adults presenting to a memory clinic with subjective cognitive decline: a pilot study. J. Alzheimers Dis. 48:Suppl. 1S151–59 [Google Scholar]
  135. Snitz BE, Small BJ, Wang T, Chang CC, Hughes TF, Ganguli M. 2015b. Do subjective memory complaints lead or follow objective cognitive change? A five-year population study of temporal influence. J. Int. Neuropsychol. Soc. 21:732–42 [Google Scholar]
  136. Snitz BE, Weissfeld LA, Cohen AD, Lopez OL, Nebes RD. et al. 2015c. Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults. Am. J. Geriatr. Psychiatry 23:985–93 [Google Scholar]
  137. Sohlberg MM, Mateer CA. 2001. Cognitive Rehabilitation: An Integrative Neuropsychological Approach New York: Guilford [Google Scholar]
  138. Solhan M, Trull TJ, Jahng S, Wood P. 2009. Clinical assessment of affective instability: comparing EMA indices, questionnaire reports, and retrospective recall. Psychol. Assess. 21:425–36 [Google Scholar]
  139. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S. et al. 2011. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7:280–92 [Google Scholar]
  140. Srivastava S, John OP, Gosling SD, Potter J. 2013. Development of personality in early and middle adulthood: set like plaster or persistent change?. J. Pers. Soc. Psychol. 84:1041–53 [Google Scholar]
  141. Steffens DC, Potter GG. 2008. Geriatric depression and cognitive impairment. Psychol. Med. 38:163–75 [Google Scholar]
  142. Sternberg RJ, Kaufman JC. 1998. Human abilities. Annu. Rev. Psychol. 49:479–502 [Google Scholar]
  143. Stewart R, Godin O, Crivello F, Maillard P, Mazoyer B. et al. 2011. Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Br. J. Psychiatry 198:199–205 [Google Scholar]
  144. Stone AA, Shiffman S. 1994. Ecological momentary assessment in behavioral medicine. Ann. Behav. Med. 16:199–202 [Google Scholar]
  145. Striepens N, Scheef L, Wind A, Meiberth D, Popp J. et al. 2010. Volume loss of the medial temporal lobe structures in subjective memory impairment. Dement. Geriatr. Cogn. Disord. 29:75–81 [Google Scholar]
  146. Striepens N, Scheef L, Wind A, Meiberth D, Popp J. et al. 2011. Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume. Psychol. Med. 41:1997–2006 [Google Scholar]
  147. Tan CC, Yu JT, Wang HF, Tan MS, Meng XF. et al. 2014. Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. J. Alzheimers Dis. 41:615–31 [Google Scholar]
  148. Tandetnik C, Farrell MT, Cary MS, Cines S, Emrani S. et al. 2015. Ascertaining subjective cognitive decline: a comparison of approaches and evidence for using an age-anchored reference group. J. Alzheimers Dis. 48:S43–55 [Google Scholar]
  149. Tobiansky R, Blizard R, Livingston G, Mann A. 1995. The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people. Psychol. Med. 25:779–86 [Google Scholar]
  150. Troyer A. 2001. Improving memory knowledge, satisfaction, and functioning via an education and intervention program for older adults. Aging Neuropsychol. Cogn. 8:256–68 [Google Scholar]
  151. Trull TJ, Ebner-Priemer U. 2013. Ambulatory assessment. Annu. Rev. Clin. Psychol. 9:151–76 [Google Scholar]
  152. Valech N, Mollica MA, Olives J, Tort A, Fortea J. et al. 2015. Informants' perception of subjective cognitive decline helps to discriminate preclinical Alzheimer's disease from normal aging. J. Alzheimers Dis. 48:Suppl. 1S87–98 [Google Scholar]
  153. van der Flier WM, van Buchem MA, Weverling-Rijnsburger AW, Mutsaers ER, Bollen EL. et al. 2004. Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. J. Neurol. 251:671–75 [Google Scholar]
  154. van Harten AC, Visser PJ, Pijnenburg YA, Teunissen CE, Blankenstein MA. et al. 2013. Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints. Alzheimers Dement 9:481–87 [Google Scholar]
  155. van Heugten C, Gregório GW, Wade D. 2012. Evidence-based cognitive rehabilitation after acquired brain injury: a systematic review of content of treatment. Neuropsychol. Rehabil. 22:653–73 [Google Scholar]
  156. van Oijen M, de Jong FJ, Hofman A, Koudstaal PJ, Breteler MM. 2007. Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimers Dement 3:92–97 [Google Scholar]
  157. Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund LO. et al. 2009. Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol 8:619–27 [Google Scholar]
  158. Wang L, van Belle G, Crane PK, Kukull WA, Bowen JD. et al. 2004. Subjective memory deterioration and future dementia in people aged 65 and older. J. Am. Geriatr. Soc. 52:2045–51 [Google Scholar]
  159. Wiegand MA, Troyer AK, Gojmerac C, Murphy KJ. 2013. Facilitating change in health-related behaviors and intentions: a randomized controlled trial of a multidimensional memory program for older adults. Aging Ment. Health 17:806–15 [Google Scholar]
  160. Wolfsgruber S, Kleineidam L, Wagner M, Mösch E, Bickel H. et al. 2016. Differential risk of incident AD dementia in stable versus unstable patterns of subjective cognitive decline. J. Alzheimers Dis. 54:31135–46 [Google Scholar]
  161. Yesavage JA, Brink T, Rose T, Lum O, Huang V. et al. 1982. Development and validation of a geriatric depression screening scale: a preliminary report. J. Psychiatr. Res. 17:37–49 [Google Scholar]
  162. Zwan MD, Villemagne VL, Dore V, Buckley R, Bourgeat P. et al. 2015. Subjective memory complaints in APOEε4 carriers are associated with high amyloid-beta burden. J. Alzheimers Dis. 49:1115–22 [Google Scholar]

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