1932

Abstract

T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (T) cells are the specialized providers of B cell help. T cells depend on expression of the master regulator transcription factor Bcl6. Distinguishing features of T cells are the expression of CXCR5, PD-1, SAP (SH2D1A), IL-21, and ICOS, among other molecules, and the absence of Blimp-1 (). T cells are important for the formation of germinal centers. Once germinal centers are formed, T cells are needed to maintain them and to regulate germinal center B cell differentiation into plasma cells and memory B cells. This review covers T differentiation, T functions, and human T cells, discussing recent progress and areas of uncertainty or disagreement in the literature, and it debates the developmental relationship between T cells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg).

Loading

Article metrics loading...

/content/journals/10.1146/annurev-immunol-031210-101400
2011-04-23
2024-06-19
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-immunol-031210-101400
Loading
/content/journals/10.1146/annurev-immunol-031210-101400
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error