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Annual Review of Immunology

Volume 34, 2016

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

Abstract

MHC class II (MHC-II) molecules are critical in the control of many immune responses. They are also involved in most autoimmune diseases and other pathologies. Here, we describe the biology of MHC-II and MHC-II variations that affect immune responses. We discuss the classic cell biology of MHC-II and various perturbations. Proteolysis is a major process in the biology of MHC-II, and we describe the various components forming and controlling this endosomal proteolytic machinery. This process ultimately determines the MHC-II–presented peptidome, including cryptic peptides, modified peptides, and other peptides that are relevant in autoimmune responses. MHC-II also variable in expression, glycosylation, and turnover. We illustrate that MHC-II is variable not only in amino acids (polymorphic) but also in its biology, with consequences for both health and disease.

Keyword(s): antigen presentation, autoimmunity, cathepsins, HLA, inhibitors, MHC class II, polymorphism, processing
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/content/journals/10.1146/annurev-immunol-041015-055420
2016-05-20
2025-02-18
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Variations in MHC Class II Antigen Processing and Presentation in Health and Disease
Annual Review of Immunology 34, 265 (2016); https://doi.org/10.1146/annurev-immunol-041015-055420
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