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Annual Review of Immunology

Volume 40, 2022

Emerging Functions of IL-33 in Homeostasis and Immunity

Abstract

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2+ regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.

Keyword(s): cytokines, damage-associated molecular patterns, homeostasis, IL-33, tissue repair, type 2 immunity
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/content/journals/10.1146/annurev-immunol-101320-124243
2022-04-26
2024-05-08
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Emerging Functions of IL-33 in Homeostasis and Immunity
Annual Review of Immunology 40, 15 (2022); https://doi.org/10.1146/annurev-immunol-101320-124243
/content/journals/10.1146/annurev-immunol-101320-124243
/content/journals/10.1146/annurev-immunol-101320-124243
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