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Annual Review of Medicine

Volume 70, 2019

Long-Acting HIV Drugs for Treatment and Prevention

Abstract

Antiretroviral drugs have revolutionized the treatment and prevention of HIV infection; however, adherence is critical for sustained efficacy. Current HIV treatment consists of three-drug regimens, and current HIV pre-exposure prophylaxis (PrEP) consists of a two-drug regimen; both generally require adherence to once-daily dosing. Long-acting formulations are useful in the treatment and prevention of other conditions (e.g., contraceptives, antipsychotics) and help promote adherence. Newer long-acting formulations of approved and investigational antiretroviral drugs in existing and newer mechanistic classes are under study for HIV treatment and prevention, including some phase III trials. Although long-acting antiretroviral drugs hold promise, some clinical challenges exist, including managing side effects, drug-drug interactions, pregnancy, and long-lasting drug concentrations that could lead to the development of drug resistance. This review aims to summarize currently available information on long-acting antiretroviral drugs for HIV treatment and prevention.

Keyword(s): antiretroviral drugs, extended-release, HIV, implants, long-acting, monoclonal antibodies
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2019-01-27
2025-02-17
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/content/journals/10.1146/annurev-med-041217-013717
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Long-Acting HIV Drugs for Treatment and Prevention
Annual Review of Medicine 70, 137 (2019); https://doi.org/10.1146/annurev-med-041217-013717
/content/journals/10.1146/annurev-med-041217-013717
/content/journals/10.1146/annurev-med-041217-013717
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