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Annual Review of Medicine

Volume 74, 2023

New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics

Abstract

Nearly half of Americans are projected to have obesity by 2030, underscoring the pressing need for effective treatments. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) represent the first agents in a rapidly evolving, highly promising landscape of nascent hormone-based obesity therapeutics. With the understanding of the neurobiology of obesity rapidly expanding, these emerging entero-endocrine and endo-pancreatic agents combined or coformulated with GLP-1 RAs herald a new era of targeted, mechanism-based treatment of obesity. This article reviews GLP-1 RAs in the treatment of obesity and previews the imminent future of nutrient-stimulated hormone-based anti-obesity therapeutics.

Keyword(s): antiobesity medications, dual receptor agonists, GLP-1 receptor agonists, NuSH-based therapies, nutrient-stimulated hormone-based therapies, triple receptor agonists
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/content/journals/10.1146/annurev-med-043021-014919
2023-01-27
2025-04-19
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New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics
Annual Review of Medicine 74, 125 (2023); https://doi.org/10.1146/annurev-med-043021-014919
/content/journals/10.1146/annurev-med-043021-014919
/content/journals/10.1146/annurev-med-043021-014919
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