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Annual Review of Medicine

Volume 72, 2021

Treating Coronary Artery Disease: Beyond Statins, Ezetimibe, and PCSK9 Inhibition

Abstract

Statins, ezetimibe, and PCSK9 inhibitors are currently the standard of care for the prevention and treatment of coronary artery disease. Despite their widespread use, coronary artery disease remains the leading cause of death worldwide, a fact that pleads for the development of new protective therapies. In no small part due to advances in the field of human genetics, many new therapies targeting various lipid traits or inflammation have recently received approval from regulatory agencies such as the US Food and Drug Administration or fared favorably in clinical trials. This wave of new therapies promises to transform the care of patients at risk for life-threatening coronary events.

Keyword(s): cholesterol, coronary artery disease, genetics, inflammation, lipoproteins, triglycerides
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/content/journals/10.1146/annurev-med-080819-044918
2021-01-27
2025-04-25
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/content/journals/10.1146/annurev-med-080819-044918
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Treating Coronary Artery Disease: Beyond Statins, Ezetimibe, and PCSK9 Inhibition
Annual Review of Medicine 72, 447 (2021); https://doi.org/10.1146/annurev-med-080819-044918
/content/journals/10.1146/annurev-med-080819-044918
/content/journals/10.1146/annurev-med-080819-044918
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