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Annual Review of Microbiology

Volume 73, 2019

Small Is Mighty—Chemical Communication Systems in

Abstract

is an opportunistic pathogen that causes a variety of acute and chronic infections. Usually a commensal on the host body, is capable of transforming into a virulent pathogen upon sensing favorable changes in the host immune system or stress cues. infections are hard to eradicate, because this pathogen has developed strong resistance to most conventional antibiotics; in addition, in chronic infections it commonly forms a biofilm matrix, which provides bacterial cells a protected environment to withstand various stresses including antibiotics. Given its importance as a human pathogen and its notorious antimicrobial tolerance, has been the subject of intensive investigations internationally. Research progress over the last two decades has unveiled a range of chemical communication systems in this pathogen. These diversified chemical communication systems endow a superb ability and remarkable flexibility to coordinate and modulate accordingly the transcriptional expression of various sets of genes associated with virulence and other physiologic activities in response to environmental changes. A fair understanding of the chemical signaling mechanisms with which governs virulence gene expression may hold the key to developing alternative therapeutic interventions that control and prevent bacterial infections.

Keyword(s): cyclic dipeptide, diffusible signal factor, IQS, phenylacetic acid, polyamine, quorum sensing
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2019-09-08
2025-05-01
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/content/journals/10.1146/annurev-micro-020518-120044
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Small Is Mighty—Chemical Communication Systems in Pseudomonas aeruginosa
Annual Review of Microbiology 73, 559 (2019); https://doi.org/10.1146/annurev-micro-020518-120044
/content/journals/10.1146/annurev-micro-020518-120044
/content/journals/10.1146/annurev-micro-020518-120044
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