1932

Abstract

I was surprised to be invited to write a prefatory chapter for the . Indeed, I did not feel that I belonged to that class of eminent scientists who had written such chapters. Perhaps it is because I am a kind of mutant: In spite of having experienced war, both German and Soviet occupations, repeated bombardments, dictatorships, and a revolution, I managed nonetheless to engage in scientific research, thus realizing a childhood dream. After having obtained my Doctor Rerum Naturalium degree in Budapest, Hungary, I was fortunate to meet Jacques Monod at the Pasteur Institute, and this became a turning point in my scientific career. In his laboratory, I contributed to the definition of the lactose operon promoter, uncovered intracistronic complementation in β-galactosidase, and investigated the role of cAMP in . In my own laboratory, together with many gifted students and collaborators, I studied the role of adenylate cyclase in bacterial virulence. This allowed the engineering of recombinant adenylate cyclase toxin from for the development of protective and therapeutic vaccines.

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2012-10-13
2024-10-13
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Literature Cited

  1. Antonini E, Wyman J, Moretti R, Rossi-Fanelli A. 1.  1963. The interaction of bromthymol blue with hemoglobin and its effect on the oxygen equilibrium. Biochem. Biophys. Acta 71:124–32 [Google Scholar]
  2. Aricò B, Scarlato V, Monack DM, Falkow S, Rappuoli R. 2.  1991. Structural and genetic analysis of the bvg locus in Bordetella species. Mol. Microbiol. 5:2481–91 [Google Scholar]
  3. Buc MH, Ullmann A, Goldberg ME, Buc H. 3.  1971. Masse moléculaire et coefficient d'extinction de la glycogène phosphorylase b du muscle de lapin. Biochimie 53:283–89 [Google Scholar]
  4. Celada F, Ullmann A, Monod J. 4.  1974. An immunological study of complementary fragments of β-galactosidase. Biochemistry 13:5543–47 [Google Scholar]
  5. Confer DL, Eaton JW. 5.  1982. Phagocyte impotence caused by the invasive bacterial adenylate cyclase. Science 217:948–95 [Google Scholar]
  6. Dessein A, Schwartz M, Ullmann A. 6.  1978. Catabolite repression in Escherichia coli mutants lacking cyclic AMP. Mol. Gen. Genet. 162:83–87 [Google Scholar]
  7. Dienert F. 7.  1900. Sur la fermentation du galactose et sur l'accoutumance des levures à ce sucre. Ann. Inst. Pasteur Paris 19:139–89 [Google Scholar]
  8. Erdos T, Ullmann A. 8.  1959. Effect of streptomycin on the incorporation of amino acids labelled with carbon-14 into ribonucleic acid and protein in a cell-free system of a Mycobacterium. Nature 183:618–19 [Google Scholar]
  9. Erdos T, Ullmann A. 9.  1960. Effect of streptomycin on the incorporation of tyrosine labelled with carbon14 into protein of Mycobacterium cell fractions in vivo. Nature 185:100–101 [Google Scholar]
  10. Fayolle C, Ladant D, Karimova G, Ullmann A, Leclec C. 10.  1999. Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope. J. Immunol. 162:4157–62 [Google Scholar]
  11. Fayolle C, Sebo P, Ladant D, Ullmann A, Leclerc C. 11.  1996. In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T-cell epitopes. J. Immunol. 156:4697–706 [Google Scholar]
  12. Fischer EH, Appleman MM, Krebs EG. 12.  1964. The structure of phosphorylases. Ciba Foundation Symposium – Control of Glycogen Metabolism H Whelan, MP Cameron 94–106 Chichester, UK: Wiley [Google Scholar]
  13. Gilbert W, Müller-Hill B. 13.  1966. Isolation of the lac repressor. Proc. Natl. Acad. Sci. USA 56:1891–98 [Google Scholar]
  14. Glaser P, Ladant D, Sezer O, Pichot F, Ullmann A, Danchin A. 14.  1988. The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli. Mol. Microbiol. 2:19–30 [Google Scholar]
  15. Goyard S, Ullmann A. 15.  1993. Functional analysis of the cya promoter of Bordetella pertussis. Mol. Microbiol. 7:693–704 [Google Scholar]
  16. Gros F, Gilbert W, Hiatt HH, Attardi G, Spahr PF, Watson JD. 16.  1961. Molecular and biological characterization of messenger RNA. Cold Spring Harb. Symp. Quant. Biol. 26:111–13 [Google Scholar]
  17. Guidi-Rontani C, Danchin A, Ullmann A. 17.  1984. Transcriptional control of polarity in Escherichia coli by cAMP. Mol. Gen. Genet. 195:96–100 [Google Scholar]
  18. Guiso N, Ullmann A. 18.  1976. Expression and regulation of lactose genes carried by plasmids. J. Bacteriol. 127:691–97 [Google Scholar]
  19. Guo Q, Shen Y, Lee YS, Gibbs CS, Mrksich M, Tang W-J. 19.  2005. Structural basis for the interaction of Bordetella pertussis adenylate cyclase toxin with calmodulin. EMBO J. 24:3190–201 [Google Scholar]
  20. Hewlett EL, Wolff J. 20.  1976. Soluble abenylate cyclase from the culture medium Bordetella pertussis: purification and characterization. J. Bacteriol. 127:890–98 [Google Scholar]
  21. Jacob F, Ullmann A, Monod J. 21.  1965. Délétions fusionnant l'opéron lactose et un opéron purine chez Escherichia coli.. J. Mol. Biol. 31:704–19 [Google Scholar]
  22. Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. 22.  1994. Three-dimensional structure of β-galactosidase of E. coli.. Nature 369:761–66 [Google Scholar]
  23. Karimova G, Bellalou J, Ullmann A. 23.  1996. Phosphorylation-dependent binding of BvgA to the upstream region of the cyaA gene of Bordetella pertussis. Mol. Microbiol. 20:489–96 [Google Scholar]
  24. Karimova G, Pidoux J, Ullmann A, Ladant D. 24.  1998. A bacterial two-hybrid system based on a reconstituted signal transduction pathway. Proc. Natl. Acad. Sci. USA 95:5752–56 [Google Scholar]
  25. Kolb A, Busby S, Buc H, Garges S, Adhya S. 25.  1993. Transcriptional activation by cAMP and its receptor protein. Annu. Rev. Biochem. 62:749–95 [Google Scholar]
  26. Krebs EG, Fischer EH. 26.  1962. Molecular properties and transformations of glycogen phosphorylase in animal tissues. Adv. Enzymol. 24:263–90 [Google Scholar]
  27. Ladant D. 27.  1988. Interaction of Bordetella pertussis adenylate cyclase with calmodulin: identification of two separate calmodulin binding domains. J. Biol. Chem. 263:2612–18 [Google Scholar]
  28. Ladant D, Glaser P, Ullmann A. 28.  1992. Insertional mutagenesis of Bordetella pertussis adenylate cyclase. J. Biol. Chem. 267:2244–50 [Google Scholar]
  29. Ladant D, Ullmann A. 29.  1999. Bordetella pertussis adenylate cyclase: a toxin with multiple talents. Trends Microbiol. 7:172–76 [Google Scholar]
  30. Laoide BM, Ullmann A. 30.  1990. Virulence dependent and independent regulation of the Bordetella pertussis cya operon. EMBO J. 9:999–1005 [Google Scholar]
  31. Leppla SH. 31.  1982. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations in eukaryotic cells. Proc. Natl. Acad. Sci. USA 79:3162–66 [Google Scholar]
  32. Magasanik B. 32.  1970. Glucose effects: inducer exclusion and repression. The Lactose Operon JR Beckwith, D Zipser 189–219 Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press [Google Scholar]
  33. Makman RS, Sutherland EW. 33.  1965. Adenosine 3′,5′-phosphate in Escherichia coli.. J. Biol. Chem. 240:1309–14 [Google Scholar]
  34. Mock M, Ullmann A. 34.  1993. Calmodulin-activated bacterial adenylate cyclases as virulence factors. Trends Microbiol. 1:187–92 [Google Scholar]
  35. Monod J. 35.  1958. Recherche sur la croissance des cultures bactériennes. Paris: Hermann et Cie.210 [Google Scholar]
  36. Monod J, Cohn M. 36.  1952. La biosynthèse induite des enzymes (adaptation enzymatique). Adv. Enzymol. 13:67–119 [Google Scholar]
  37. Pardee AB, Jacob F, Monod J. 37.  1959. The genetic control and cytoplasmic expression of “inducibility” in the synthesis of β-galactosidase in Escherichia coli.. J. Mol. Biol. 1:165–78 [Google Scholar]
  38. Perrin D. 38.  1963. Complementation between products of the β-galactosidase structural gene of Escherichia coli.. Cold Spring Harbor Symp. Quant. Biol 28:529–31 [Google Scholar]
  39. Roy A, Danchin A, Joseph E, Ullmann A. 39.  1983. Two functional domains in adenylate cyclase of Escherichia coli.. J. Mol. Biol. 165:197–202 [Google Scholar]
  40. Sanzey B, Ullmann A. 40.  1976. Urea, a specific inhibitor of catabolite sensitive operons. Biochem. Biophys. Res. Commun. 71:1062–68 [Google Scholar]
  41. Saron MF, Fayolle C, Sebo P, Ladant D, Ullmann A, Leclerc C. 41.  1997. Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus. Proc. Natl. Acad. Sci. USA 94:3314–19 [Google Scholar]
  42. Sebo P, Glaser P, Sakamoto H, Ullmann A. 42.  1991. High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system. Gene 10:19–24 [Google Scholar]
  43. Seery VL, Fischer EH, Teller DC. 43.  1967. A reinvestigation of the molecular weight of glycogen phosphorylase. Biochemistry 6:3315–27 [Google Scholar]
  44. Sory MP, Cornelis GR. 44.  1994. Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol. Microbiol. 14:583–94 [Google Scholar]
  45. Steffen P, Goyard S, Ullmann A. 45.  1996. Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis. EMBO J. 15:102–109 [Google Scholar]
  46. Ullmann A. 46.  1984. One-step purification of hybrid proteins which have β-galactosidase activity. Gene 29:27–31 [Google Scholar]
  47. Ullmann A, Danchin A. 47.  1983. Role of cyclic AMP in bacteria. Advances in Cyclic Nucleotide Research P Greengard, GA Robison 151–53 New York: Raven Press [Google Scholar]
  48. Ullmann A, Goldberg ME, Perrin D, Monod J. 48.  1968. On the determination of molecular weight of proteins and protein subunits in 6M guanidine. Biochemistry 7:261–65 [Google Scholar]
  49. Ullmann A, Jacob F, Monod J. 49.  1967. Characterization by in vitro complementation of a peptide corresponding to an operator proximal segment of the β-galactosidase structural gene of Escherichia coli.. J. Mol. Biol. 24:339–43 [Google Scholar]
  50. Ullmann A, Jacob F, Monod J. 50.  1968. On the subunit structure of wild-type versus complemented β-galactosidase of Escherichia coli.. J. Mol. Biol. 32:1–13 [Google Scholar]
  51. Ullmann A, Joseph E, Danchin A. 51.  1979. Cyclic AMP as a modulator of polarity in polycistronic transcriptional units. Proc. Natl. Acad. Sci. USA 76:3194–97 [Google Scholar]
  52. Ullmann A, Monod J. 52.  1968. Cyclic AMP as an antagonist of catabolite repression in Escherichia coli.. FEBS Lett. 2:57–60 [Google Scholar]
  53. Ullmann A, Perrin D, Jacob F, Monod J. 53.  1965. Identification par complémentation in vitro et purification d'un segment peptidique de la β-galactosidase d'Escherichia coli.. J. Mol. Biol. 12:918–23 [Google Scholar]
  54. Ullmann A, Tillier F, Monod J. 54.  1976. Catabolite modulator factor: a possible mediator of catabolite repression in bacteria. Proc. Natl. Acad. Sci. USA 73:3476–79 [Google Scholar]
  55. Ullmann A, Vagelos PR, Monod J. 55.  1964. The effect of 5′ adenylic acid upon the association between bromthymol blue and muscle phosphorylase b. Biochem. Biophys. Res. Commun. 17:86–92 [Google Scholar]
  56. Weiss AA, Falkow S. 56.  1984. Genetic analysis of phase change in Bordetella pertussis. Infect. Immun. 43:263–69 [Google Scholar]
  57. Wolff J, Cook GH, Goldhammer AR, Berkowitz SA. 57.  1980. Calmodulin activates prokaryotic adenylate cyclase. Proc. Natl. Acad. Sci. USA 77:3840–44 [Google Scholar]
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