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Annual Review of Nutrition

Volume 43, 2023

Osteocalcin: A Multifaceted Bone-Derived Hormone

Abstract

Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following its binding to one of three receptors, osteocalcin exerts a profound influence on various aspects of energy metabolism as well as steroidogenesis, neurotransmitter biosynthesis and thereby male fertility, electrolyte homeostasis, cognition, the acute stress response, and exercise capacity. Although this review focuses mostly on the regulation of energy metabolism by osteocalcin, it also touches on its other functions. Lastly, it proposes what could be a common theme between the functions of osteocalcin and between these functions and the structural functions of bone.

Keyword(s): bone, danger repellent, energy metabolism, osteocalcin, undercarboxylation
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/content/journals/10.1146/annurev-nutr-061121-091348
2023-08-21
2024-05-02
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/content/journals/10.1146/annurev-nutr-061121-091348
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Osteocalcin: A Multifaceted Bone-Derived Hormone
Annual Review of Nutrition 43, 55 (2023); https://doi.org/10.1146/annurev-nutr-061121-091348
/content/journals/10.1146/annurev-nutr-061121-091348
/content/journals/10.1146/annurev-nutr-061121-091348
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  • Article Type: Review Article

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